Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[6]
References
^ abcGRCh38: Ensembl release 89: ENSG00000184357 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
^Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
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Collar DG, Wright KL, van Wijnen AJ, et al. (1988). "The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down-regulated during terminal differentiation in HL60 cells". J. Biol. Chem. 263 (31): 15860–3. doi:10.1016/S0021-9258(18)37527-6. PMID 3182772.
Ohe Y, Hayashi H, Iwai K (1986). "Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b". J. Biochem. 100 (2): 359–68. doi:10.1093/oxfordjournals.jbchem.a121722. PMID 3782055.
Carozzi N, Marashi F, Plumb M, et al. (1984). "Clustering of human H1 and core histone genes". Science. 224 (4653): 1115–7. Bibcode:1984Sci...224.1115C. doi:10.1126/science.6719136. PMID 6719136.
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Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
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hist1h1b, histone, protein, that, humans, encoded, gene, 5available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes2rhiidentifiersaliasesh1, h1f5, histone, cluster, histone, cluster, family, member, linker, histone, cluster, memberexternal, idsomim. Histone H1 5 is a protein that in humans is encoded by the HIST1H1B gene 3 4 5 6 H1 5Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes2RHIIdentifiersAliasesH1 5 H1 H1 5 H1B H1F5 H1s 3 histone cluster 1 H1b histone cluster 1 H1 family member b HIST1H1B H1 5 linker histone cluster memberExternal IDsOMIM 142711 HomoloGene 136789 GeneCards H1 5Gene location Human Chr Chromosome 6 human 1 Band6p22 1Start27 866 792 bp 1 End27 867 588 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inbone marrow cellstendonAchilles tendonganglionic eminencethymusmonocytebloodcorpus callosumskeletal muscle tissuefacen aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding histone deacetylase binding chromatin DNA binding RNA binding protein binding double stranded DNA binding nucleosomal DNA bindingCellular componentnucleosome extracellular exosome chromosome nucleusBiological processestablishment of protein localization to chromatin nucleosome assembly protein stabilization positive regulation of cell growth negative regulation of transcription by RNA polymerase II chromatin organization positive regulation of histone H3 K9 methylation regulation of transcription DNA templated chromosome condensation negative regulation of DNA recombination muscle organ developmentSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez3009n aEnsemblENSG00000184357n aUniProtP16401n aRefSeq mRNA NM 005322n aRefSeq protein NP 005313n aLocation UCSC Chr 6 27 87 27 87 Mbn aPubMed search 2 n aWikidataView Edit HumanHistones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes Two molecules of each of the four core histones H2A H2B H3 and H4 form an octamer around which approximately 146 bp of DNA is wrapped in repeating units called nucleosomes The linker histone H1 interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures This gene is intronless and encodes a member of the histone H1 family Transcripts from this gene lack polyA tails but instead contain a palindromic termination element This gene is found in the small histone gene cluster on chromosome 6p22 p21 3 6 References Edit a b c GRCh38 Ensembl release 89 ENSG00000184357 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Albig W Meergans T Doenecke D Mar 1997 Characterization of the H1 5 gene completes the set of human H1 subtype genes Gene 184 2 141 8 doi 10 1016 S0378 1119 96 00582 3 PMID 9031620 Albig W Kioschis P Poustka A Meergans K Doenecke D Apr 1997 Human histone gene organization nonregular arrangement within a large cluster Genomics 40 2 314 22 doi 10 1006 geno 1996 4592 PMID 9119399 Marzluff WF Gongidi P Woods KR Jin J Maltais LJ Oct 2002 The human and mouse replication dependent histone genes Genomics 80 5 487 98 doi 10 1016 S0888 7543 02 96850 3 PMID 12408966 a b Entrez Gene HIST1H1B histone cluster 1 H1b Further reading EditOhe Y Hayashi H Iwai K 1990 Human spleen histone H1 Isolation and amino acid sequences of three minor variants H1a H1c and H1d J Biochem 106 5 844 57 doi 10 1093 oxfordjournals jbchem a122941 PMID 2613692 van Wijnen AJ Wright KL Massung RF et al 1988 Two target sites for protein binding in the promoter region of a cell cycle regulated human H1 histone gene Nucleic Acids Res 16 2 571 92 doi 10 1093 nar 16 2 571 PMC 334679 PMID 2829131 Collar DG Wright KL van Wijnen AJ et al 1988 The human H1 histone gene FNC16 is functionally expressed in proliferating HeLa S3 cells and is down regulated during terminal differentiation in HL60 cells J Biol Chem 263 31 15860 3 doi 10 1016 S0021 9258 18 37527 6 PMID 3182772 Ohe Y Hayashi H Iwai K 1986 Human spleen histone H1 Isolation and amino acid sequence of a main variant H1b J Biochem 100 2 359 68 doi 10 1093 oxfordjournals jbchem a121722 PMID 3782055 Carozzi N Marashi F Plumb M et al 1984 Clustering of human H1 and core histone genes Science 224 4653 1115 7 Bibcode 1984Sci 224 1115C doi 10 1126 science 6719136 PMID 6719136 Aprelikova O Xiong Y Liu ET 1995 Both p16 and p21 families of cyclin dependent kinase CDK inhibitors block the phosphorylation of cyclin dependent kinases by the CDK activating kinase J Biol Chem 270 31 18195 7 doi 10 1074 jbc 270 31 18195 PMID 7629134 Albig W Drabent B Kunz J et al 1993 All known human H1 histone genes except the H1 0 gene are clustered on chromosome 6 Genomics 16 3 649 54 doi 10 1006 geno 1993 1243 PMID 8325638 Albig W Doenecke D 1998 The human histone gene cluster at the D6S105 locus Hum Genet 101 3 284 94 doi 10 1007 s004390050630 PMID 9439656 S2CID 38539096 New L Zhao M Li Y et al 1999 Cloning and characterization of RLPK a novel RSK related protein kinase J Biol Chem 274 2 1026 32 doi 10 1074 jbc 274 2 1026 PMID 9873047 Chadwick BP Willard HF 2001 A Novel Chromatin Protein Distantly Related to Histone H2a Is Largely Excluded from the Inactive X Chromosome J Cell Biol 152 2 375 84 doi 10 1083 jcb 152 2 375 PMC 2199617 PMID 11266453 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Giampuzzi M Oleggini R Di Donato A 2003 Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2 definition of the regions involved Biochim Biophys Acta 1647 1 2 245 51 doi 10 1016 s1570 9639 03 00059 1 PMID 12686141 Mungall AJ Palmer SA Sims SK et al 2003 The DNA sequence and analysis of human chromosome 6 Nature 425 6960 805 11 Bibcode 2003Natur 425 805M doi 10 1038 nature02055 PMID 14574404 Vaquero A Scher M Lee D et al 2004 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin Mol Cell 16 1 93 105 doi 10 1016 j molcel 2004 08 031 PMID 15469825 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Garcia BA Busby SA Barber CM et al 2005 Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry J Proteome Res 3 6 1219 27 doi 10 1021 pr0498887 PMID 15595731 Andersen JS Lam YW Leung AK et al 2005 Nucleolar proteome dynamics Nature 433 7021 77 83 Bibcode 2005Natur 433 77A doi 10 1038 nature03207 PMID 15635413 S2CID 4344740 This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HIST1H1B amp oldid 1115824916, wikipedia, wiki, book, books, library,
