Glucan 1,4-alpha-maltohydrolase (EC 3.2.1.133, maltogenic alpha-amylase, 1,4-alpha-D-glucan alpha-maltohydrolase) is an enzyme with systematic name4-alpha-D-glucan alpha-maltohydrolase.[1][2] This enzyme catalyses the following chemical reaction
hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains
This enzyme acts on starch and related polysaccharides and oligosaccharides. Maltogenic amylases from Bacillus stearothermophilus,[3] Thermus sp.[4] and Geobacillus thermoleovorans[5] are able to degrade acarbose to glucose and acarviosine-glucose.
Acarbose is degraded by different enzymes in the gut microbiome. secretion of gut bacterial enzymes inhibit acarbose.
Referencesedit
^Diderichsen B, Christiansen L (1988). "Cloning of a maltogenic α-amylase from Bacillus stearothermophilus". FEMS Microbiol. Lett. 56: 53–59. doi:10.1111/j.1574-6968.1988.tb03149.x.
^Outtrup H, Norman BE (1984). "Properties and application of a thermostable maltogenic amylase produced by a strain of Bacillus modified by recombinant-DNA techniques". Stärke. 36 (12): 405–411. doi:10.1002/star.19840361202.
^Cha HJ, Yoon HG, Kim YW, Lee HS, Kim JW, Kweon KS, et al. (April 1998). "Molecular and enzymatic characterization of a maltogenic amylase that hydrolyzes and transglycosylates acarbose". European Journal of Biochemistry. 253 (1): 251–262. doi:10.1046/j.1432-1327.1998.2530251.x. PMID 9578484.
^Kim TJ, Kim MJ, Kim BC, Kim JC, Cheong TK, Kim JW, Park KH (April 1999). "Modes of action of acarbose hydrolysis and transglycosylation catalyzed by a thermostable maltogenic amylase, the gene for which was cloned from a Thermus strain". Applied and Environmental Microbiology. 65 (4): 1644–1651. Bibcode:1999ApEnM..65.1644K. doi:10.1128/AEM.65.4.1644-1651.1999. PMC91232. PMID 10103262.
^Mehta D, Satyanarayana T (2013-09-19). "Dimerization mediates thermo-adaptation, substrate affinity and transglycosylation in a highly thermostable maltogenic amylase of Geobacillus thermoleovorans". PLOS ONE. 8 (9): e73612. Bibcode:2013PLoSO...873612M. doi:10.1371/journal.pone.0073612. PMC3777949. PMID 24069213.
External linksedit
Glucan+1,4-alpha-maltohydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
glucan, alpha, maltohydrolase, maltogenic, alpha, amylase, alpha, glucan, alpha, maltohydrolase, enzyme, with, systematic, name, alpha, glucan, alpha, maltohydrolase, this, enzyme, catalyses, following, chemical, reactionidentifiersec, 133cas, 160611, 2databas. Glucan 1 4 alpha maltohydrolase EC 3 2 1 133 maltogenic alpha amylase 1 4 alpha D glucan alpha maltohydrolase is an enzyme with systematic name 4 alpha D glucan alpha maltohydrolase 1 2 This enzyme catalyses the following chemical reactionGlucan 1 4 alpha maltohydrolaseIdentifiersEC no 3 2 1 133CAS no 160611 47 2DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins hydrolysis of 1 gt 4 alpha D glucosidic linkages in polysaccharides so as to remove successive alpha maltose residues from the non reducing ends of the chains This enzyme acts on starch and related polysaccharides and oligosaccharides Maltogenic amylases from Bacillus stearothermophilus 3 Thermus sp 4 and Geobacillus thermoleovorans 5 are able to degrade acarbose to glucose and acarviosine glucose Acarbose is degraded by different enzymes in the gut microbiome secretion of gut bacterial enzymes inhibit acarbose References edit Diderichsen B Christiansen L 1988 Cloning of a maltogenic a amylase from Bacillus stearothermophilus FEMS Microbiol Lett 56 53 59 doi 10 1111 j 1574 6968 1988 tb03149 x Outtrup H Norman BE 1984 Properties and application of a thermostable maltogenic amylase produced by a strain of Bacillus modified by recombinant DNA techniques Starke 36 12 405 411 doi 10 1002 star 19840361202 Cha HJ Yoon HG Kim YW Lee HS Kim JW Kweon KS et al April 1998 Molecular and enzymatic characterization of a maltogenic amylase that hydrolyzes and transglycosylates acarbose European Journal of Biochemistry 253 1 251 262 doi 10 1046 j 1432 1327 1998 2530251 x PMID 9578484 Kim TJ Kim MJ Kim BC Kim JC Cheong TK Kim JW Park KH April 1999 Modes of action of acarbose hydrolysis and transglycosylation catalyzed by a thermostable maltogenic amylase the gene for which was cloned from a Thermus strain Applied and Environmental Microbiology 65 4 1644 1651 Bibcode 1999ApEnM 65 1644K doi 10 1128 AEM 65 4 1644 1651 1999 PMC 91232 PMID 10103262 Mehta D Satyanarayana T 2013 09 19 Dimerization mediates thermo adaptation substrate affinity and transglycosylation in a highly thermostable maltogenic amylase of Geobacillus thermoleovorans PLOS ONE 8 9 e73612 Bibcode 2013PLoSO 873612M doi 10 1371 journal pone 0073612 PMC 3777949 PMID 24069213 External links editGlucan 1 4 alpha maltohydrolase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title Glucan 1 4 alpha maltohydrolase amp oldid 1221313459, wikipedia, wiki, book, books, library,
