A giant depolarizing potential (GDP) is a type of patterned spontaneous activity that can be observed in preparations of developing brain at early stages of development.[1] These patterns of activity differ a lot from both the adult brain activity, and epileptiform activity. In humans they exist only on prenatal stages, in rats they last for approximately P6.
GDPs were postulated to be essential for the establishment and maturation of synaptic connections in the immature brain [citation needed].
One of the main conditions for GDP development (that is met in premature but not adult brain) is that GABA action on these stages should be excitatory rather than inhibitory. This is caused by a much higher concentration of Cl− concentration in the cytoplasm of neonatal neurons. Further, the expression of the chloride transporter, KCC2, is less in immature neurons, as a result of which there is the above-mentioned high intracellular chloride. On receiving a GABAergic stimulus, there is an efflux of Chloride from the cell, resulting in depolarization of the cell. This causes the GDPs. Once the KCC2 expression is relatively high, as in the adult, mature neurons, the GDPs almost simultaneously disappear. The increased level of KCC2 expression in adult, mature neurons alone is not the reason for the disappearance of the GDPs, however[citation needed].
Referencesedit
^Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R (October 2007). "GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations". Physiol. Rev. 87 (4): 1215–84. doi:10.1152/physrev.00017.2006. PMID 17928584.
May 05, 2024
giant, depolarizing, potential, giant, depolarizing, potential, type, patterned, spontaneous, activity, that, observed, preparations, developing, brain, early, stages, development, these, patterns, activity, differ, from, both, adult, brain, activity, epilepti. A giant depolarizing potential GDP is a type of patterned spontaneous activity that can be observed in preparations of developing brain at early stages of development 1 These patterns of activity differ a lot from both the adult brain activity and epileptiform activity In humans they exist only on prenatal stages in rats they last for approximately P6 GDPs were postulated to be essential for the establishment and maturation of synaptic connections in the immature brain citation needed One of the main conditions for GDP development that is met in premature but not adult brain is that GABA action on these stages should be excitatory rather than inhibitory This is caused by a much higher concentration of Cl concentration in the cytoplasm of neonatal neurons Further the expression of the chloride transporter KCC2 is less in immature neurons as a result of which there is the above mentioned high intracellular chloride On receiving a GABAergic stimulus there is an efflux of Chloride from the cell resulting in depolarization of the cell This causes the GDPs Once the KCC2 expression is relatively high as in the adult mature neurons the GDPs almost simultaneously disappear The increased level of KCC2 expression in adult mature neurons alone is not the reason for the disappearance of the GDPs however citation needed References edit Ben Ari Y Gaiarsa JL Tyzio R Khazipov R October 2007 GABA a pioneer transmitter that excites immature neurons and generates primitive oscillations Physiol Rev 87 4 1215 84 doi 10 1152 physrev 00017 2006 PMID 17928584 Retrieved from https en wikipedia org w index php title Giant depolarizing potential amp oldid 867223951, wikipedia, wiki, book, books, library,
