Germacradienol synthase (EC 4.2.3.22, germacradienol/germacrene-D synthase, 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]) is an enzyme with systematic name(2E,6E)-farnesyl-diphosphate diphosphate-lyase ((1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming).[1][2][3] This enzyme catalyses the following chemical reaction
^Cane DE, Watt RM (February 2003). "Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1547–51. doi:10.1073/pnas.0337625100. PMC149869. PMID 12556563.
^He X, Cane DE (March 2004). "Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2)". Journal of the American Chemical Society. 126 (9): 2678–9. doi:10.1021/ja039929k. PMID 14995166.
^Gust B, Challis GL, Fowler K, Kieser T, Chater KF (February 2003). "PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1541–6. doi:10.1073/pnas.0337542100. PMC149868. PMID 12563033.
External linksedit
Germacradienol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
germacradienol, synthase, germacradienol, germacrene, synthase, trans, trans, farnesyl, diphosphate, diphosphate, lyase, germacra, dien, forming, enzyme, with, systematic, name, farnesyl, diphosphate, diphosphate, lyase, germacra, dien, forming, this, enzyme, . Germacradienol synthase EC 4 2 3 22 germacradienol germacrene D synthase 2 trans 6 trans farnesyl diphosphate diphosphate lyase 1E 4S 5E 7R germacra 1 10 5 dien 11 ol forming is an enzyme with systematic name 2E 6E farnesyl diphosphate diphosphate lyase 1E 4S 5E 7R germacra 1 10 5 dien 11 ol forming 1 2 3 This enzyme catalyses the following chemical reactionGermacradienol synthaseIdentifiersEC no 4 2 3 22CAS no 211049 88 6DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins 2E 6E farnesyl diphosphate H2O displaystyle rightleftharpoons 1E 4S 5E 7R germacra 1 10 5 dien 11 ol diphosphate This enzyme requires Mg2 for activity References edit Cane DE Watt RM February 2003 Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis Proceedings of the National Academy of Sciences of the United States of America 100 4 1547 51 doi 10 1073 pnas 0337625100 PMC 149869 PMID 12556563 He X Cane DE March 2004 Mechanism and stereochemistry of the germacradienol germacrene D synthase of Streptomyces coelicolor A3 2 Journal of the American Chemical Society 126 9 2678 9 doi 10 1021 ja039929k PMID 14995166 Gust B Challis GL Fowler K Kieser T Chater KF February 2003 PCR targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin Proceedings of the National Academy of Sciences of the United States of America 100 4 1541 6 doi 10 1073 pnas 0337542100 PMC 149868 PMID 12563033 External links editGermacradienol synthase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title Germacradienol synthase amp oldid 1172347666, wikipedia, wiki, book, books, library,
