The germ-line theory was a proposed explanation for immunoglobulin diversity that proposed that each antibody was encoded in a separate germline gene.[1][2]
This does not occur in most species (including humans), but may occur in Elasmobranchs.[1]
For decades microbiologists searched for a mechanism that could explain the large diversity of antibody structure. For this reason the germ line theory emerged. According to this theory, the genomes contributed by the germ cell, sperm and egg contained a large repertoire of immunoglobulin genes. It was clear that there should be a mechanism that help the antibody to have diversity and keep it constant. The germ line theory could not provide any explanation on this aspect.
germ, line, theory, this, article, needs, additional, citations, verification, please, help, improve, this, article, adding, citations, reliable, sources, unsourced, material, challenged, removed, find, sources, news, newspapers, books, scholar, jstor, july, 2. This article needs additional citations for verification Please help improve this article by adding citations to reliable sources Unsourced material may be challenged and removed Find sources Germ line theory news newspapers books scholar JSTOR July 2016 Learn how and when to remove this message The germ line theory was a proposed explanation for immunoglobulin diversity that proposed that each antibody was encoded in a separate germline gene 1 2 This does not occur in most species including humans but may occur in Elasmobranchs 1 For decades microbiologists searched for a mechanism that could explain the large diversity of antibody structure For this reason the germ line theory emerged According to this theory the genomes contributed by the germ cell sperm and egg contained a large repertoire of immunoglobulin genes It was clear that there should be a mechanism that help the antibody to have diversity and keep it constant The germ line theory could not provide any explanation on this aspect References edit a b germline theory Glossary NCBI Lefers Mark germ line theory Glossary Northwestern University Retrieved 28 February 2012 nbsp This history of medicine article is a stub You can help Wikipedia by expanding it vte nbsp This immunology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Germ line theory amp oldid 1170095631, wikipedia, wiki, book, books, library,
