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Gcn4 is a transcription factor and a “master regulator” for gene expression which regulates close to one tenth of the yeast genome. In a study by Razaghi et al,[1] amino acid starvation activated the transcription factor Gcn4p, resulting in transcriptional induction of almost all genes involved in amino acid biosynthesis, including HIS4. Thus involvement of Gcn4 in regulation of both histidinol dehydrogenaseHIS4 and interferon gammahIFNγ was hypothesised as a scenario explaining the increased level of hIFNγ under amino acid starvation.[1]
Overexpression of Gcn4 leads to the reduction in protein synthesis capacity which contributes to Gcn4-mediated increase of yeast lifespan.[3]
In budding yeast, deletion of Gcn4 prevents HIS4 from targeting to the nuclear periphery upon transcriptional activation, indicating that Gcn4 is necessary for regulation of gene positioning and transcription.[4]
^ abRazaghi, Ali; Huerlimann, Roger; Owens, Leigh; Heimann, Kirsten (1 December 2015). "Increased expression and secretion of recombinant hIFNγ through amino acid starvation-induced selective pressure on the adjacent HIS4 gene in Pichia pastoris". Acta Facultatis Pharmaceuticae Universitatis Comenianae. 62 (2): 43–50. doi:10.1515/afpuc-2015-0031.
^Murguía, José R.; Serrano, Ramón (2012). "New functions of protein kinase Gcn2 in yeast and mammals". IUBMB Life. 64 (12): 971–974. doi:10.1002/iub.1090. PMID 23129244.
^Mittal, Nitish; Guimaraes, Joao C.; Gross, Thomas; Schmidt, Alexander; Vina-Vilaseca, Arnau; Nedialkova, Danny D.; Aeschimann, Florian; Leidel, Sebastian A.; Spang, Anne; Zavolan, Mihaela (2017). "The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan". Nature Communications. 8 (1): 457. Bibcode:2017NatCo...8..457M. doi:10.1038/s41467-017-00539-y. PMC5587724. PMID 28878244.
^Randise-Hinchliff, Carlo; Brickner, Jason H. (2016). "Transcription factors dynamically control the spatial organization of the yeast genome". Nucleus. 7 (4): 369–374. doi:10.1080/19491034.2016.1212797. PMC5039007. PMID 27442220.
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gcn4, this, article, relies, largely, entirely, single, source, relevant, discussion, found, talk, page, please, help, improve, this, article, introducing, citations, additional, sources, find, sources, news, newspapers, books, scholar, jstor, february, 2016, . This article relies largely or entirely on a single source Relevant discussion may be found on the talk page Please help improve this article by introducing citations to additional sources Find sources Gcn4 news newspapers books scholar JSTOR February 2016 Gcn4 is a transcription factor and a master regulator for gene expression which regulates close to one tenth of the yeast genome In a study by Razaghi et al 1 amino acid starvation activated the transcription factor Gcn4p resulting in transcriptional induction of almost all genes involved in amino acid biosynthesis including HIS4 Thus involvement of Gcn4 in regulation of both histidinol dehydrogenase HIS4 and interferon gamma hIFNg was hypothesised as a scenario explaining the increased level of hIFNg under amino acid starvation 1 Gcn4 is a highly conserved protein and its mammalian homolog is known as activating transcription factor 4 ATF4 2 Overexpression of Gcn4 leads to the reduction in protein synthesis capacity which contributes to Gcn4 mediated increase of yeast lifespan 3 In budding yeast deletion of Gcn4 prevents HIS4 from targeting to the nuclear periphery upon transcriptional activation indicating that Gcn4 is necessary for regulation of gene positioning and transcription 4 See also editDNA binding protein Transcription factorExternal links editReferences edit a b Razaghi Ali Huerlimann Roger Owens Leigh Heimann Kirsten 1 December 2015 Increased expression and secretion of recombinant hIFNg through amino acid starvation induced selective pressure on the adjacent HIS4 gene in Pichia pastoris Acta Facultatis Pharmaceuticae Universitatis Comenianae 62 2 43 50 doi 10 1515 afpuc 2015 0031 Murguia Jose R Serrano Ramon 2012 New functions of protein kinase Gcn2 in yeast and mammals IUBMB Life 64 12 971 974 doi 10 1002 iub 1090 PMID 23129244 Mittal Nitish Guimaraes Joao C Gross Thomas Schmidt Alexander Vina Vilaseca Arnau Nedialkova Danny D Aeschimann Florian Leidel Sebastian A Spang Anne Zavolan Mihaela 2017 The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan Nature Communications 8 1 457 Bibcode 2017NatCo 8 457M doi 10 1038 s41467 017 00539 y PMC 5587724 PMID 28878244 Randise Hinchliff Carlo Brickner Jason H 2016 Transcription factors dynamically control the spatial organization of the yeast genome Nucleus 7 4 369 374 doi 10 1080 19491034 2016 1212797 PMC 5039007 PMID 27442220 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Gcn4 amp oldid 1110786456, wikipedia, wiki, book, books, library,
