GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase (EC 2.4.1.292, PglH) is an enzyme with systematic nameUDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
^Glover KJ, Weerapana E, Imperiali B (October 2005). "In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation". Proceedings of the National Academy of Sciences of the United States of America. 102 (40): 14255–9. Bibcode:2005PNAS..10214255G. doi:10.1073/pnas.0507311102. PMC1242339. PMID 16186480.
^Troutman JM, Imperiali B (March 2009). "Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions". Biochemistry. 48 (12): 2807–16. doi:10.1021/bi802284d. PMC2736683. PMID 19159314.
^Børud B, Viburiene R, Hartley MD, Paulsen BS, Egge-Jacobsen W, Imperiali B, Koomey M (June 2011). "Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system". Proceedings of the National Academy of Sciences of the United States of America. 108 (23): 9643–8. Bibcode:2011PNAS..108.9643B. doi:10.1073/pnas.1103321108. PMC3111294. PMID 21606362.
External linksedit
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol+alpha-1,4-N-acetyl-D-galactosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
galnac, alpha, galnac, alpha, dinacbac, undecaprenol, alpha, acetyl, galactosaminyltransferase, galnac, alpha, galnac, alpha, dinacbac, undecaprenol, alpha, acetyl, galactosaminyltransferase, pglh, enzyme, with, systematic, name, acetyl, alpha, galactosamine, . GalNAc alpha 1 gt 4 GalNAc alpha 1 gt 3 diNAcBac PP undecaprenol alpha 1 4 N acetyl D galactosaminyltransferase EC 2 4 1 292 PglH is an enzyme with systematic name UDP N acetyl alpha D galactosamine GalNAc alpha 1 gt 4 GalNAc alpha 1 gt 3 diNAcBac PP tritrans heptacis undecaprenol 4 alpha N acetyl D galactosaminyltransferase 1 2 3 This enzyme catalyses the following chemical reactionGalNAc alpha 1 gt 4 GalNAc alpha 1 gt 3 diNAcBac PP undecaprenol alpha 1 4 N acetyl D galactosaminyltransferaseIdentifiersEC no 2 4 1 292DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins 3 UDP N acetyl alpha D galactosamine GalNAc alpha 1 gt 4 GalNAc alpha 1 gt 3 diNAcBac PP tritrans heptacis undecaprenol displaystyle rightleftharpoons 3 UDP GalNAc alpha 1 gt 4 4 GalNAc alpha 1 gt 3 diNAcBac PP tritrans heptacis undecaprenolThis enzyme is solated from Campylobacter jejuni References edit Glover KJ Weerapana E Imperiali B October 2005 In vitro assembly of the undecaprenylpyrophosphate linked heptasaccharide for prokaryotic N linked glycosylation Proceedings of the National Academy of Sciences of the United States of America 102 40 14255 9 Bibcode 2005PNAS 10214255G doi 10 1073 pnas 0507311102 PMC 1242339 PMID 16186480 Troutman JM Imperiali B March 2009 Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions Biochemistry 48 12 2807 16 doi 10 1021 bi802284d PMC 2736683 PMID 19159314 Borud B Viburiene R Hartley MD Paulsen BS Egge Jacobsen W Imperiali B Koomey M June 2011 Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system Proceedings of the National Academy of Sciences of the United States of America 108 23 9643 8 Bibcode 2011PNAS 108 9643B doi 10 1073 pnas 1103321108 PMC 3111294 PMID 21606362 External links editGalNAc alpha 1 gt 4 GalNAc alpha 1 gt 3 diNAcBac PP undecaprenol alpha 1 4 N acetyl D galactosaminyltransferase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title GalNAc alpha 1 4 GalNAc alpha 1 3 diNAcBac PP undecaprenol alpha 1 4 N acetyl D galactosaminyltransferase amp oldid 1198289694, wikipedia, wiki, book, books, library,
