Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1gene.[3][4] It belongs to the dynamin superfamily of large GTPases.[5]
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.[4]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000117228 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790.
^ ab"Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa".
Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell. Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
Naschberger E, Bauer M, Stürzl M (2006). "Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases". Adv. Enzyme Regul. 45: 215–27. doi:10.1016/j.advenzreg.2005.02.011. PMID 16005050.
Cheng YS, Patterson CE, Staeheli P (1991). "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP". Mol. Cell. Biol. 11 (9): 4717–25. doi:10.1128/MCB.11.9.4717. PMC361367. PMID 1715024.
Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc. Biol. 60 (3): 423–31. doi:10.1002/jlb.60.3.423. PMID 8830800. S2CID 33727864.
Saunders NA, Smith RJ, Jetten AM (1999). "Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells". J. Invest. Dermatol. 112 (6): 977–83. doi:10.1046/j.1523-1747.1999.00611.x. PMID 10383748.
Prakash B, Praefcke GJ, Renault L, et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature. 403 (6769): 567–71. Bibcode:2000Natur.403..567P. doi:10.1038/35000617. PMID 10676968. S2CID 4431592.
Kumar S, Li Q, Dua A, et al. (2001). "Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation". J. Clin. Endocrinol. Metab. 86 (6): 2420–7. doi:10.1210/jcem.86.6.7534. PMID 11397834.
Guenzi E, Töpolt K, Cornali E, et al. (2001). "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines". EMBO J. 20 (20): 5568–77. doi:10.1093/emboj/20.20.5568. PMC125279. PMID 11598000.
Lubeseder-Martellato C, Guenzi E, Jörg A, et al. (2002). "Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases". Am. J. Pathol. 161 (5): 1749–59. doi:10.1016/S0002-9440(10)64452-5. PMC1850787. PMID 12414522.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
Guenzi E, Töpolt K, Lubeseder-Martellato C, et al. (2003). "The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression". EMBO J. 22 (15): 3772–82. doi:10.1093/emboj/cdg382. PMC169055. PMID 12881412.
Naschberger E, Werner T, Vicente AB, et al. (2004). "Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells". Biochem. J. 379 (Pt 2): 409–20. doi:10.1042/BJ20031873. PMC1224089. PMID 14741045.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Praefcke GJ, Kloep S, Benscheid U, et al. (2004). "Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis". J. Mol. Biol. 344 (1): 257–69. doi:10.1016/j.jmb.2004.09.026. PMID 15504415.
Modiano N, Lu YE, Cresswell P (2005). "Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-γ-inducible cofactor". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8680–5. Bibcode:2005PNAS..102.8680M. doi:10.1073/pnas.0503227102. PMC1150846. PMID 15937107.
Ghosh A, Praefcke GJ, Renault L, et al. (2006). "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP". Nature. 440 (7080): 101–4. Bibcode:2006Natur.440..101G. doi:10.1038/nature04510. PMID 16511497. S2CID 4405773.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.
gbp1, interferon, induced, guanylate, binding, protein, protein, that, humans, encoded, gene, belongs, dynamin, superfamily, large, gtpases, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes1dg3, 1f5n, 2b8w, 2b92, 2bc9, 2d4hidentifiersalias. Interferon induced guanylate binding protein 1 is a protein that in humans is encoded by the GBP1 gene 3 4 It belongs to the dynamin superfamily of large GTPases 5 GBP1Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1DG3 1F5N 2B8W 2B92 2BC9 2D4HIdentifiersAliasesGBP1 guanylate binding protein 1External IDsOMIM 600411 HomoloGene 133759 GeneCards GBP1Gene location Human Chr Chromosome 1 human 1 Band1p22 2Start89 051 882 bp 1 End89 065 360 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inpericardiumtrigeminal ganglionlower lobe of lungsuperficial temporal arteryappendixgallbladdermonocytevena cavalymph nodehuman penisn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionnucleotide binding Hsp90 protein binding spectrin binding protein binding identical protein binding enzyme binding actin binding hydrolase activity cytokine binding GTPase activity GTP binding GDP binding protein homodimerization activityCellular componentcytosol membrane Golgi membrane plasma membrane extracellular region cytoplasm Golgi apparatus vesicle membrane actin cytoskeleton cytoplasmic vesicleBiological processimmune system process interferon gamma mediated signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of protein localization to plasma membrane defense response to virus regulation of calcium mediated signaling negative regulation of ERK1 and ERK2 cascade negative regulation of substrate adhesion dependent cell spreading regulation of protein localization to plasma membrane protein homooligomerization cellular response to interferon gamma cellular response to interleukin 1 cellular response to tumor necrosis factor protein localization to vacuoleSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2633n aEnsemblENSG00000117228n aUniProtP32455n aRefSeq mRNA NM 002053n aRefSeq protein NP 002044n aLocation UCSC Chr 1 89 05 89 07 Mbn aPubMed search 2 n aWikidataView Edit HumanFunction editGuanylate binding protein expression is induced by interferon Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides GMP GDP and GTP and are distinguished from the GTP binding proteins by the presence of 2 binding motifs rather than 3 4 References edit a b c GRCh38 Ensembl release 89 ENSG00000117228 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Strehlow I Lohmann Matthes ML Decker T Aug 1994 The interferon inducible GBP1 gene structure and mapping to human chromosome 1 Gene 144 2 295 9 doi 10 1016 0378 1119 94 90393 X PMID 7518790 a b Entrez Gene GBP1 guanylate binding protein 1 interferon inducible 67kDa Praefcke GJ McMahon HT February 2004 The dynamin superfamily universal membrane tubulation and fission molecules Nat Rev Mol Cell Biol 5 2 133 47 doi 10 1038 nrm1313 PMID 15040446 S2CID 6305282 Further reading editAnderson NL Anderson NG 2003 The human plasma proteome history character and diagnostic prospects Mol Cell Proteomics 1 11 845 67 doi 10 1074 mcp R200007 MCP200 PMID 12488461 Naschberger E Bauer M Sturzl M 2006 Human guanylate binding protein 1 hGBP 1 characterizes and establishes a non angiogenic endothelial cell activation phenotype in inflammatory diseases Adv Enzyme Regul 45 215 27 doi 10 1016 j advenzreg 2005 02 011 PMID 16005050 Cheng YS Patterson CE Staeheli P 1991 Interferon induced guanylate binding proteins lack an N T KXD consensus motif and bind GMP in addition to GDP and GTP Mol Cell Biol 11 9 4717 25 doi 10 1128 MCB 11 9 4717 PMC 361367 PMID 1715024 Nantais DE Schwemmle M Stickney JT et al 1996 Prenylation of an interferon gamma induced GTP binding protein the human guanylate binding protein huGBP1 J Leukoc Biol 60 3 423 31 doi 10 1002 jlb 60 3 423 PMID 8830800 S2CID 33727864 Saunders NA Smith RJ Jetten AM 1999 Regulation of guanylate binding protein expression in interferon gamma treated human epidermal keratinocytes and squamous cell carcinoma cells J Invest Dermatol 112 6 977 83 doi 10 1046 j 1523 1747 1999 00611 x PMID 10383748 Prakash B Praefcke GJ Renault L et al 2000 Structure of human guanylate binding protein 1 representing a unique class of GTP binding proteins Nature 403 6769 567 71 Bibcode 2000Natur 403 567P doi 10 1038 35000617 PMID 10676968 S2CID 4431592 Kumar S Li Q Dua A et al 2001 Messenger ribonucleic acid encoding interferon inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation J Clin Endocrinol Metab 86 6 2420 7 doi 10 1210 jcem 86 6 7534 PMID 11397834 Guenzi E Topolt K Cornali E et al 2001 The helical domain of GBP 1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines EMBO J 20 20 5568 77 doi 10 1093 emboj 20 20 5568 PMC 125279 PMID 11598000 Lubeseder Martellato C Guenzi E Jorg A et al 2002 Guanylate Binding Protein 1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases Am J Pathol 161 5 1749 59 doi 10 1016 S0002 9440 10 64452 5 PMC 1850787 PMID 12414522 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Adkins JN Varnum SM Auberry KJ et al 2003 Toward a human blood serum proteome analysis by multidimensional separation coupled with mass spectrometry Mol Cell Proteomics 1 12 947 55 doi 10 1074 mcp M200066 MCP200 PMID 12543931 Guenzi E Topolt K Lubeseder Martellato C et al 2003 The guanylate binding protein 1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP 1 expression EMBO J 22 15 3772 82 doi 10 1093 emboj cdg382 PMC 169055 PMID 12881412 Naschberger E Werner T Vicente AB et al 2004 Nuclear factor kappaB motif and interferon alpha stimulated response element co operate in the activation of guanylate binding protein 1 expression by inflammatory cytokines in endothelial cells Biochem J 379 Pt 2 409 20 doi 10 1042 BJ20031873 PMC 1224089 PMID 14741045 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Praefcke GJ Kloep S Benscheid U et al 2004 Identification of residues in the human guanylate binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis J Mol Biol 344 1 257 69 doi 10 1016 j jmb 2004 09 026 PMID 15504415 Modiano N Lu YE Cresswell P 2005 Golgi targeting of human guanylate binding protein 1 requires nucleotide binding isoprenylation and an IFN g inducible cofactor Proc Natl Acad Sci U S A 102 24 8680 5 Bibcode 2005PNAS 102 8680M doi 10 1073 pnas 0503227102 PMC 1150846 PMID 15937107 Ghosh A Praefcke GJ Renault L et al 2006 How guanylate binding proteins achieve assembly stimulated processive cleavage of GTP to GMP Nature 440 7080 101 4 Bibcode 2006Natur 440 101G doi 10 1038 nature04510 PMID 16511497 S2CID 4405773 nbsp This article on a gene on human chromosome 1 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GBP1 amp oldid 1136276073, wikipedia, wiki, book, books, library,
