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GABA transaminase inhibitor

April 12, 2024

In pharmacology, a GABA transaminase inhibitor is an enzyme inhibitor that acts upon GABA transaminase.[1] Inhibition of GABA transaminase enzymes reduces the degradation of GABA, leading to increased neuronal GABA concentrations.

Examples include valproic acid,[2] vigabatrin,[3][4] phenylethylidenehydrazine (and drugs that metabolize to it, such as phenelzine[5]), ethanolamine-O-sulfate (EOS), and L-cycloserine.[6]

Certain members of this class are used as anticonvulsants.

References edit

  1. ^ Ciesielski, L.; Simler, S.; Gensburger, C.; Mandel, P.; Taillandier, G.; Benoit-Guyod, J. L.; Boucherle, A.; Cohen-Addad, C.; Lajzerowicz, J. (1979). "GABA Transaminase Inhibitors". GABA—Biochemistry and CNS Functions. Advances in Experimental Medicine and Biology. Vol. 123. pp. 21–41. doi:10.1007/978-1-4899-5199-1_2. ISBN 978-1-4899-5201-1. PMID 390993.
  2. ^ Bruni, J.; Wilder, B. J. (1979). "Valproic acid. Review of a new antiepileptic drug". Archives of Neurology. 36 (7): 393–398. doi:10.1001/archneur.1979.00500430023002. PMID 110294.
  3. ^ Wang QP, Jammoul F, Duboc A, et al. (April 2008). "Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina". Eur. J. Neurosci. 27 (8): 2177–87. doi:10.1111/j.1460-9568.2008.06175.x. PMC 2933832. PMID 18412635.
  4. ^ Gibson, J. P.; Yarrington, J. T.; Loudy, D. E.; Gerbig, C. G.; Hurst, G. H.; Newberne, J. W. (1990). "Chronic toxicity studies with vigabatrin, a GABA-transaminase inhibitor". Toxicologic Pathology. 18 (2): 225–238. doi:10.1177/019262339001800201. PMID 2399411.
  5. ^ McKenna, K. F.; McManus, D. J.; Baker, G. B.; Coutts, R. T. (1994). "Chronic administration of the antidepressant phenelzine and its N-acetyl analogue: effects on GABAergic function". Journal of Neural Transmission. Supplementum. 41: 115–122. doi:10.1007/978-3-7091-9324-2_15. ISBN 978-3-211-82521-1. ISSN 0303-6995. PMID 7931216.
  6. ^ Polc, P.; Pieri, L.; Bonetti, E. P.; Scherschlicht, R.; Moehler, H.; Kettler, R.; Burkard, W.; Haefely, W. (1986). "L-cycloserine: Behavioural and biochemical effects after single and repeated administration to mice, rats and cats". Neuropharmacology. 25 (4): 411–418. doi:10.1016/0028-3908(86)90236-4. PMID 3012401. S2CID 462885.

April 12, 2024
gaba, transaminase, inhibitor, pharmacology, enzyme, inhibitor, that, acts, upon, gaba, transaminase, inhibition, gaba, transaminase, enzymes, reduces, degradation, gaba, leading, increased, neuronal, gaba, concentrations, examples, include, valproic, acid, vi. In pharmacology a GABA transaminase inhibitor is an enzyme inhibitor that acts upon GABA transaminase 1 Inhibition of GABA transaminase enzymes reduces the degradation of GABA leading to increased neuronal GABA concentrations Examples include valproic acid 2 vigabatrin 3 4 phenylethylidenehydrazine and drugs that metabolize to it such as phenelzine 5 ethanolamine O sulfate EOS and L cycloserine 6 Certain members of this class are used as anticonvulsants References edit Ciesielski L Simler S Gensburger C Mandel P Taillandier G Benoit Guyod J L Boucherle A Cohen Addad C Lajzerowicz J 1979 GABA Transaminase Inhibitors GABA Biochemistry and CNS Functions Advances in Experimental Medicine and Biology Vol 123 pp 21 41 doi 10 1007 978 1 4899 5199 1 2 ISBN 978 1 4899 5201 1 PMID 390993 Bruni J Wilder B J 1979 Valproic acid Review of a new antiepileptic drug Archives of Neurology 36 7 393 398 doi 10 1001 archneur 1979 00500430023002 PMID 110294 Wang QP Jammoul F Duboc A et al April 2008 Treatment of epilepsy the GABA transaminase inhibitor vigabatrin induces neuronal plasticity in the mouse retina Eur J Neurosci 27 8 2177 87 doi 10 1111 j 1460 9568 2008 06175 x PMC 2933832 PMID 18412635 Gibson J P Yarrington J T Loudy D E Gerbig C G Hurst G H Newberne J W 1990 Chronic toxicity studies with vigabatrin a GABA transaminase inhibitor Toxicologic Pathology 18 2 225 238 doi 10 1177 019262339001800201 PMID 2399411 McKenna K F McManus D J Baker G B Coutts R T 1994 Chronic administration of the antidepressant phenelzine and its N acetyl analogue effects on GABAergic function Journal of Neural Transmission Supplementum 41 115 122 doi 10 1007 978 3 7091 9324 2 15 ISBN 978 3 211 82521 1 ISSN 0303 6995 PMID 7931216 Polc P Pieri L Bonetti E P Scherschlicht R Moehler H Kettler R Burkard W Haefely W 1986 L cycloserine Behavioural and biochemical effects after single and repeated administration to mice rats and cats Neuropharmacology 25 4 411 418 doi 10 1016 0028 3908 86 90236 4 PMID 3012401 S2CID 462885 Retrieved from https en wikipedia org w index php title GABA transaminase inhibitor amp oldid 1173502782, wikipedia, wiki, book, books, library,

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