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Fronto-cerebellar dissociation

January 01, 1970

Fronto-cerebellar dissociation is the disconnection and independent function of frontal and cerebellar regions of the brain. It is characterized by inhibited communication between the two regions, and is notably observed in cases of ADHD, schizophrenia, alcohol use disorder, and heroin use. The frontal and cerebellar regions make distinctive contributions to cognitive performance, with the left-frontal activations being responsible for selecting a response to a stimulus, while the right-cerebellar activation is responsible for the search for a given response to a stimulus. Left-frontal activation increases when there are many appropriate responses to a stimulus, and right-cerebellar activation increases when there is a single appropriate response to a stimulus. A person with dissociated frontal and cerebellar regions may have difficulties with selecting a response to a stimuli, or difficulties with response initiation.[1] Fronto-cerebellar dissociation can often result in either the frontal lobe or the cerebellum becoming more active in place of the less active region as a compensatory effect.[2][3]

Animation of the frontal lobe, shown in red

Background edit

 
Animation of the cerebellum, shown in red

Neuroanatomical studies in non-human primates have shown connections between the cerebellum and non-motor cortical areas of the frontal lobe.[4] Fronto-cerebellar circuitry is important to processes such as language, memory, and thought. Positron emission tomography has shown that when a subject was shown a noun and asked to state an associated verb, left-frontal and right-cerebellar activation was greater than if asked to simply speak the noun aloud. Generating an associated word required more fronto-cerebellar coactivation, indicating a difference between semantic retrieval and verbal working memory. Additionally, completing a word when presented a stem of the word resulted in greater left-frontal activation when there were many possible completions to the stem. Right-cerebellar activation was greater when there were fewer possible completions to the stem. These results indicate that the left-frontal activations correlate with selection of a response among many possible responses.[1][5]

Pathways edit

Two distinct fronto-cerebellar pathways have been identified through evoking and measuring field potentials on the cerebellar surface of rats. The first path originates from the PrL (prelimbic) sub-region of the mPFC (medial prefrontal cortex), and the second originates from the M2 region (premotor cortex). The path from the PrL cortex was found to be 5 milliseconds slower than the path from the M2 cortex. This difference in speed was part of the evidence supporting the idea of two pathways from independent origins. In addition, larger amplitude responses were recorded during PrL stimulation, further supporting that the pathways were separate.[6]

 
The M2 pathway is shown in red, originating in the pre-motor cortex. The PrL pathway is shown in purple, originating in the medial prefrontal cortex

The PrL cortex and M2 cortex are involved in actions such as eyeblink conditioning, action initiation and termination, conflict-monitoring between automatic and voluntary behavioral strategies, attention, and direct and indirect eye movement control. They are also involved in even higher cognitive functions such as stimulus-outcome encoding and automatization of recurrent actions.[7]

Related conditions edit

Alcohol use disorder edit

There is a reduction in functional neurological connectivity in alcohol dependent subjects, specific to the fronto-cerebellar circuits. Similar dissociation is not seen between prefrontal and premotor cortex, nor between parietal cortex and cerebellum, nor between temporal cortex and cerebellum in people who drink excessive amounts of alcohol. In alcoholic subjects, there is often decreased glucose metabolic rates in the frontal lobe, irregular glucose metabolism in frontal, parietal, and cerebellar regions, irregular concentrations of N-acetyl-aspartate and choline in the cerebellum, and abnormal grey matter volume in the nodes of fronto-cerebellar circuits.[8]

Heroin abuse edit

Studies indicate reorganization of fronto-cerebellar circuitry and fronto-cerebellar dysfunction among heroin addicted subjects. In task related fMRI, addicts showed an inverse correlation between cerebellum activation and prefrontal cortex activity. This indicates that when chronic use damages the prefrontal cortex, the importance of the cerebellum to external incentive stimuli increases. This drug-induced damage of fronto-cerebellar circuitry may result in the cerebellum taking a larger role in long-term emotional memory, behavioral sensitization, and inflexible behavior.[9]

ADHD edit

In healthy individuals, fronto-cerebellar neural networks mediate selective and sustained attention. Children and adults with Attention Deficit Hyperactivity Disorder (ADHD) show reduced functional connectivity relative to healthy controls in fronto-cerebellar networks. Such dissociation is correlated with the characteristic functions of ADHD such as set-shifting and set maintenance, higher level and selective attention, interference control, motor inhibition, integration across space and time, planning, decision making, temporal foresight, and working memory. In individuals with ADHD, there is often increased cerebellar activity due to a compensatory effect related to reduced frontal activity.[2][3]

Schizophrenia edit

Fronto-cerebellar dissociation has been associated with higher cognitive defects in individuals with schizophrenia. Behaviors such as anhedonia, the inability to experience pleasure from activities usually found enjoyable, and ambivalence, the state of having simultaneous, conflicting feelings toward a person or thing, are both attributed to fronto-cerebellar abnormalities in schizophrenic patients.[10] When healthy adults undergo infant motor development, it is characterized by increased grey matter density in the fronto-cerebellar pathways. Schizophrenic individuals often have delayed motor development, resulting in fronto-cerebellar abnormalities and decreased executive function in adulthood as a result.[11]

References edit

  1. ^ a b Desmond, JE; Gabrieli JD; Glover GH (1998). "Dissociation of frontal and cerebellar activity in a Cognitive task: evidence for a distinction between selection and search". NeuroImage. 7 (4): 368–376. doi:10.1006/nimg.1998.0340. PMID 9626676. S2CID 31715026.
  2. ^ a b Cubillo, Ana; Halari, Rozmin; Smith, Anna; Taylor, Eric; Rubia, Katya (2012). "A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention". Cortex. 48 (2): 194–215. doi:10.1016/j.cortex.2011.04.007. PMID 21575934. S2CID 5765023.
  3. ^ a b De Zeeuw, Patrick; Weusten, Juliette; Van Dijk, Sarai; Van Belle, Janna; Durston, Sarah (2012). "Deficits in Cognitive Control, Timing and Reward Sensitivity Appear to be Dissociable in ADHD". PLOS ONE. 7 (12): e51416. Bibcode:2012PLoSO...751416D. doi:10.1371/journal.pone.0051416. PMC 3517570. PMID 23236497.
  4. ^ Strick, Peter L.; Dum, Richard P.; Fiez, Julie A. (June 2009). "Cerebellum and Nonmotor Function". Annual Review of Neuroscience. 32 (1): 413–434. doi:10.1146/annurev.neuro.31.060407.125606. PMID 19555291.
  5. ^ Hogan, Michael J (2004). "The cerebellum in thought and action: A fronto-cerebellar aging hypothesis". New Ideas in Psychology. 22 (2): 97–125. doi:10.1016/j.newideapsych.2004.09.002.
  6. ^ Krienen, Fenna M; Buckner, Randy L (2009). "Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity" (PDF). Cerebral Cortex. 19 (10): 2485–97. doi:10.1093/cercor/bhp135. PMC 2742600. PMID 19592571.
  7. ^ Watson, Thomas C. (2009). "Electrophysiological mapping of novel prefrontal - cerebellar pathways". Frontiers in Integrative Neuroscience. 3: 18. doi:10.3389/neuro.07.018.2009. PMC 2737490. PMID 19738932.
  8. ^ Rogers, Baxter P; Parks, Mitchell H; Nickel, Mark K; Katwal, Santosh B; Martin, Peter R (2012). "Reduced Fronto-Cerebellar Functional Connectivity in Chronic Alcoholic Patients". Alcoholism: Clinical and Experimental Research. 36 (2): 294–301. doi:10.1111/j.1530-0277.2011.01614.x. PMC 3268944. PMID 22085135.
  9. ^ Wang, Yarong; Zhu, Jia; Li, Qiang; Li, Wei; Wu, Ning; Zheng, Ying; Chang, Haifeng; Chen, Jiajie; Wang, Wei (2013). "Altered Fronto-Striatal and Fronto-Cerebellar Circuits in Heroin-Dependent Individuals: A Resting-State fMRI Study". PLOS ONE. 8 (3): e58098. Bibcode:2013PLoSO...858098W. doi:10.1371/journal.pone.0058098. PMC 3590175. PMID 23483978.
  10. ^ Park, Kyung-Min; Kim, Jae-Jin; Seok, Jeong Ho; Chun, Ji Won; Park, Hae-Jeong; Lee, Jong Doo (2009). "Anhedonia and Ambivalence in Schizophrenic Patients with Fronto-Cerebellar Metabolic Abnormalities: A Fluoro-D-Glucose Positron Emission Tomography Study". Psychiatry Investigation. 6 (2): 72–7. doi:10.4306/pi.2009.6.2.72. PMC 2796050. PMID 20046378.
  11. ^ Ridler, K; Veijola, J. M; Tanskanen, P; Miettunen, J; Chitnis, X; Suckling, J; Murray, G. K; Haapea, M; Jones, P. B; Isohanni, M. K; Bullmore, E. T (2006). "Fronto-cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophrenia". Proceedings of the National Academy of Sciences. 103 (42): 15651–6. Bibcode:2006PNAS..10315651R. doi:10.1073/pnas.0602639103. PMC 1636802. PMID 17028177.

January 01, 1970
fronto, cerebellar, dissociation, disconnection, independent, function, frontal, cerebellar, regions, brain, characterized, inhibited, communication, between, regions, notably, observed, cases, adhd, schizophrenia, alcohol, disorder, heroin, frontal, cerebella. Fronto cerebellar dissociation is the disconnection and independent function of frontal and cerebellar regions of the brain It is characterized by inhibited communication between the two regions and is notably observed in cases of ADHD schizophrenia alcohol use disorder and heroin use The frontal and cerebellar regions make distinctive contributions to cognitive performance with the left frontal activations being responsible for selecting a response to a stimulus while the right cerebellar activation is responsible for the search for a given response to a stimulus Left frontal activation increases when there are many appropriate responses to a stimulus and right cerebellar activation increases when there is a single appropriate response to a stimulus A person with dissociated frontal and cerebellar regions may have difficulties with selecting a response to a stimuli or difficulties with response initiation 1 Fronto cerebellar dissociation can often result in either the frontal lobe or the cerebellum becoming more active in place of the less active region as a compensatory effect 2 3 Animation of the frontal lobe shown in red Contents 1 Background 2 Pathways 3 Related conditions 3 1 Alcohol use disorder 3 2 Heroin abuse 3 3 ADHD 3 4 Schizophrenia 4 ReferencesBackground edit nbsp Animation of the cerebellum shown in red Neuroanatomical studies in non human primates have shown connections between the cerebellum and non motor cortical areas of the frontal lobe 4 Fronto cerebellar circuitry is important to processes such as language memory and thought Positron emission tomography has shown that when a subject was shown a noun and asked to state an associated verb left frontal and right cerebellar activation was greater than if asked to simply speak the noun aloud Generating an associated word required more fronto cerebellar coactivation indicating a difference between semantic retrieval and verbal working memory Additionally completing a word when presented a stem of the word resulted in greater left frontal activation when there were many possible completions to the stem Right cerebellar activation was greater when there were fewer possible completions to the stem These results indicate that the left frontal activations correlate with selection of a response among many possible responses 1 5 Pathways editTwo distinct fronto cerebellar pathways have been identified through evoking and measuring field potentials on the cerebellar surface of rats The first path originates from the PrL prelimbic sub region of the mPFC medial prefrontal cortex and the second originates from the M2 region premotor cortex The path from the PrL cortex was found to be 5 milliseconds slower than the path from the M2 cortex This difference in speed was part of the evidence supporting the idea of two pathways from independent origins In addition larger amplitude responses were recorded during PrL stimulation further supporting that the pathways were separate 6 nbsp The M2 pathway is shown in red originating in the pre motor cortex The PrL pathway is shown in purple originating in the medial prefrontal cortex The PrL cortex and M2 cortex are involved in actions such as eyeblink conditioning action initiation and termination conflict monitoring between automatic and voluntary behavioral strategies attention and direct and indirect eye movement control They are also involved in even higher cognitive functions such as stimulus outcome encoding and automatization of recurrent actions 7 Related conditions editAlcohol use disorder edit There is a reduction in functional neurological connectivity in alcohol dependent subjects specific to the fronto cerebellar circuits Similar dissociation is not seen between prefrontal and premotor cortex nor between parietal cortex and cerebellum nor between temporal cortex and cerebellum in people who drink excessive amounts of alcohol In alcoholic subjects there is often decreased glucose metabolic rates in the frontal lobe irregular glucose metabolism in frontal parietal and cerebellar regions irregular concentrations of N acetyl aspartate and choline in the cerebellum and abnormal grey matter volume in the nodes of fronto cerebellar circuits 8 Heroin abuse edit Studies indicate reorganization of fronto cerebellar circuitry and fronto cerebellar dysfunction among heroin addicted subjects In task related fMRI addicts showed an inverse correlation between cerebellum activation and prefrontal cortex activity This indicates that when chronic use damages the prefrontal cortex the importance of the cerebellum to external incentive stimuli increases This drug induced damage of fronto cerebellar circuitry may result in the cerebellum taking a larger role in long term emotional memory behavioral sensitization and inflexible behavior 9 ADHD edit In healthy individuals fronto cerebellar neural networks mediate selective and sustained attention Children and adults with Attention Deficit Hyperactivity Disorder ADHD show reduced functional connectivity relative to healthy controls in fronto cerebellar networks Such dissociation is correlated with the characteristic functions of ADHD such as set shifting and set maintenance higher level and selective attention interference control motor inhibition integration across space and time planning decision making temporal foresight and working memory In individuals with ADHD there is often increased cerebellar activity due to a compensatory effect related to reduced frontal activity 2 3 Schizophrenia edit Fronto cerebellar dissociation has been associated with higher cognitive defects in individuals with schizophrenia Behaviors such as anhedonia the inability to experience pleasure from activities usually found enjoyable and ambivalence the state of having simultaneous conflicting feelings toward a person or thing are both attributed to fronto cerebellar abnormalities in schizophrenic patients 10 When healthy adults undergo infant motor development it is characterized by increased grey matter density in the fronto cerebellar pathways Schizophrenic individuals often have delayed motor development resulting in fronto cerebellar abnormalities and decreased executive function in adulthood as a result 11 References edit a b Desmond JE Gabrieli JD Glover GH 1998 Dissociation of frontal and cerebellar activity in a Cognitive task evidence for a distinction between selection and search NeuroImage 7 4 368 376 doi 10 1006 nimg 1998 0340 PMID 9626676 S2CID 31715026 a b Cubillo Ana Halari Rozmin Smith Anna Taylor Eric Rubia Katya 2012 A review of fronto striatal and fronto cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder ADHD and new evidence for dysfunction in adults with ADHD during motivation and attention Cortex 48 2 194 215 doi 10 1016 j cortex 2011 04 007 PMID 21575934 S2CID 5765023 a b De Zeeuw Patrick Weusten Juliette Van Dijk Sarai Van Belle Janna Durston Sarah 2012 Deficits in Cognitive Control Timing and Reward Sensitivity Appear to be Dissociable in ADHD PLOS ONE 7 12 e51416 Bibcode 2012PLoSO 751416D doi 10 1371 journal pone 0051416 PMC 3517570 PMID 23236497 Strick Peter L Dum Richard P Fiez Julie A June 2009 Cerebellum and Nonmotor Function Annual Review of Neuroscience 32 1 413 434 doi 10 1146 annurev neuro 31 060407 125606 PMID 19555291 Hogan Michael J 2004 The cerebellum in thought and action A fronto cerebellar aging hypothesis New Ideas in Psychology 22 2 97 125 doi 10 1016 j newideapsych 2004 09 002 Krienen Fenna M Buckner Randy L 2009 Segregated Fronto Cerebellar Circuits Revealed by Intrinsic Functional Connectivity PDF Cerebral Cortex 19 10 2485 97 doi 10 1093 cercor bhp135 PMC 2742600 PMID 19592571 Watson Thomas C 2009 Electrophysiological mapping of novel prefrontal cerebellar pathways Frontiers in Integrative Neuroscience 3 18 doi 10 3389 neuro 07 018 2009 PMC 2737490 PMID 19738932 Rogers Baxter P Parks Mitchell H Nickel Mark K Katwal Santosh B Martin Peter R 2012 Reduced Fronto Cerebellar Functional Connectivity in Chronic Alcoholic Patients Alcoholism Clinical and Experimental Research 36 2 294 301 doi 10 1111 j 1530 0277 2011 01614 x PMC 3268944 PMID 22085135 Wang Yarong Zhu Jia Li Qiang Li Wei Wu Ning Zheng Ying Chang Haifeng Chen Jiajie Wang Wei 2013 Altered Fronto Striatal and Fronto Cerebellar Circuits in Heroin Dependent Individuals A Resting State fMRI Study PLOS ONE 8 3 e58098 Bibcode 2013PLoSO 858098W doi 10 1371 journal pone 0058098 PMC 3590175 PMID 23483978 Park Kyung Min Kim Jae Jin Seok Jeong Ho Chun Ji Won Park Hae Jeong Lee Jong Doo 2009 Anhedonia and Ambivalence in Schizophrenic Patients with Fronto Cerebellar Metabolic Abnormalities A Fluoro D Glucose Positron Emission Tomography Study Psychiatry Investigation 6 2 72 7 doi 10 4306 pi 2009 6 2 72 PMC 2796050 PMID 20046378 Ridler K Veijola J M Tanskanen P Miettunen J Chitnis X Suckling J Murray G K Haapea M Jones P B Isohanni M K Bullmore E T 2006 Fronto cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophrenia Proceedings of the National Academy of Sciences 103 42 15651 6 Bibcode 2006PNAS 10315651R doi 10 1073 pnas 0602639103 PMC 1636802 PMID 17028177 Retrieved from https en wikipedia org w index php title Fronto cerebellar dissociation amp oldid 1180348050, wikipedia, wiki, book, books, library,

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