Folate receptors bind folate and reduced folic acid derivatives and mediates delivery of tetrahydrofolate to the interior of cells.[1] It is then converted from monoglutamate to polyglutamate forms - such as 5-methyltetrahydrofolate - as only monoglutamate forms can be transported across cell membranes. Polyglutamate forms are biologically active enzymatic cofactors required for many folate-dependent processes such as folate-dependent one-carbon metabolism. These proteins are attached to the membrane by a GPI anchor.[2] A riboflavin-binding protein required for the transport of riboflavin to the developing oocyte in chicken also belong to this family.
^Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, et al. (September 2013). "Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition". Proceedings of the National Academy of Sciences of the United States of America. 110 (38): 15180–8. Bibcode:2013PNAS..11015180W. doi:10.1073/pnas.1308827110. PMC3780903. PMID 23934049.
^Antony AC (1996). "Folate receptors". Annual Review of Nutrition. 16: 501–21. doi:10.1146/annurev.nu.16.070196.002441. PMID 8839936.
This article incorporates text from the public domain Pfam and InterPro: IPR004269
January 01, 1970
folate, receptor, bind, folate, reduced, folic, acid, derivatives, mediates, delivery, tetrahydrofolate, interior, cells, then, converted, from, monoglutamate, polyglutamate, forms, such, methyltetrahydrofolate, only, monoglutamate, forms, transported, across,. Folate receptors bind folate and reduced folic acid derivatives and mediates delivery of tetrahydrofolate to the interior of cells 1 It is then converted from monoglutamate to polyglutamate forms such as 5 methyltetrahydrofolate as only monoglutamate forms can be transported across cell membranes Polyglutamate forms are biologically active enzymatic cofactors required for many folate dependent processes such as folate dependent one carbon metabolism These proteins are attached to the membrane by a GPI anchor 2 A riboflavin binding protein required for the transport of riboflavin to the developing oocyte in chicken also belong to this family Folate receptor familyIdentifiersSymbolFolate recPfamPF03024InterProIPR004269Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Human proteins from this family include FOLR1 folate receptor 1 adult FOLR2 folate receptor 2 fetal and FOLR3 folate receptor gamma References edit Wibowo AS Singh M Reeder KM Carter JJ Kovach AR Meng W et al September 2013 Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition Proceedings of the National Academy of Sciences of the United States of America 110 38 15180 8 Bibcode 2013PNAS 11015180W doi 10 1073 pnas 1308827110 PMC 3780903 PMID 23934049 Antony AC 1996 Folate receptors Annual Review of Nutrition 16 501 21 doi 10 1146 annurev nu 16 070196 002441 PMID 8839936 This article incorporates text from the public domain Pfam and InterPro IPR004269 Retrieved from https en wikipedia org w index php title Folate receptor amp oldid 1088277126, wikipedia, wiki, book, books, library,
