Evx1 is a mammalian gene located downstream of the HoxA cluster, which encodes for a homeobox transcription factor. Evx1 is a homolog of even-skipped (eve), which is a pair-rule gene that regulates body segmentation in Drosophila.[1][2] The expression of Evx1 is developmentally regulated, displaying a biphasic expression pattern with peak expression in the primitive streak during gastrulation and in interneurons during neural development.[3][4] Evx1 has been shown to regulate anterior-posterior patterning during gastrulation by acting as a downstream effector of the Wnt and BMP signalling pathways.[4][5] It is also a critical regulator of interneuron identity.[6]
Despite a regulatory role in both of these processes, the Evx1 KO mouse is viable and displays no overt phenotype after birth.[4][6]
A divergent long non-coding RNA (Evx1as) is also expressed from the locus, which is temporally and spatially co-expressed with Evx1.[3][4][7] Evx1as does not have a function beyond that of Evx1 (in trans);[4] however, it has been shown to regulate Evx1 at the locus (in cis).[7]
Referencesedit
^Nüsslein-Volhard, Christiane; Wieschaus, Eric (1980-10-30). "Mutations affecting segment number and polarity in Drosophila". Nature. 287 (5785): 795–801. Bibcode:1980Natur.287..795N. doi:10.1038/287795a0. PMID 6776413. S2CID 4337658.
^Manoukian, A. S.; Krause, H. M. (1992-09-01). "Concentration-dependent activities of the even-skipped protein in Drosophila embryos". Genes & Development. 6 (9): 1740–1751. doi:10.1101/gad.6.9.1740. ISSN 0890-9369. PMID 1355458.
^ abDinger, Marcel E.; Amaral, Paulo P.; Mercer, Tim R.; Pang, Ken C.; Bruce, Stephen J.; Gardiner, Brooke B.; Askarian-Amiri, Marjan E.; Ru, Kelin; Soldà, Giulia (2008-09-01). "Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation". Genome Research. 18 (9): 1433–1445. doi:10.1101/gr.078378.108. ISSN 1088-9051. PMC2527704. PMID 18562676.
^ abcdeBell, Charles C.; Amaral, Paulo P.; Kalsbeek, Anton; Magor, Graham W.; Gillinder, Kevin R.; Tangermann, Pierre; Lisio, Lorena di; Cheetham, Seth W.; Gruhl, Franziska (2016-05-26). "The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation". Scientific Reports. 6: 26657. Bibcode:2016NatSR...626657B. doi:10.1038/srep26657. ISSN 2045-2322. PMC4880930. PMID 27226347.
evx1, this, article, provides, insufficient, context, those, unfamiliar, with, subject, please, help, improve, article, providing, more, context, reader, 2016, learn, when, remove, this, message, mammalian, gene, located, downstream, hoxa, cluster, which, enco. This article provides insufficient context for those unfamiliar with the subject Please help improve the article by providing more context for the reader May 2016 Learn how and when to remove this message Evx1 is a mammalian gene located downstream of the HoxA cluster which encodes for a homeobox transcription factor Evx1 is a homolog of even skipped eve which is a pair rule gene that regulates body segmentation in Drosophila 1 2 The expression of Evx1 is developmentally regulated displaying a biphasic expression pattern with peak expression in the primitive streak during gastrulation and in interneurons during neural development 3 4 Evx1 has been shown to regulate anterior posterior patterning during gastrulation by acting as a downstream effector of the Wnt and BMP signalling pathways 4 5 It is also a critical regulator of interneuron identity 6 Despite a regulatory role in both of these processes the Evx1 KO mouse is viable and displays no overt phenotype after birth 4 6 A divergent long non coding RNA Evx1as is also expressed from the locus which is temporally and spatially co expressed with Evx1 3 4 7 Evx1as does not have a function beyond that of Evx1 in trans 4 however it has been shown to regulate Evx1 at the locus in cis 7 References edit Nusslein Volhard Christiane Wieschaus Eric 1980 10 30 Mutations affecting segment number and polarity in Drosophila Nature 287 5785 795 801 Bibcode 1980Natur 287 795N doi 10 1038 287795a0 PMID 6776413 S2CID 4337658 Manoukian A S Krause H M 1992 09 01 Concentration dependent activities of the even skipped protein in Drosophila embryos Genes amp Development 6 9 1740 1751 doi 10 1101 gad 6 9 1740 ISSN 0890 9369 PMID 1355458 a b Dinger Marcel E Amaral Paulo P Mercer Tim R Pang Ken C Bruce Stephen J Gardiner Brooke B Askarian Amiri Marjan E Ru Kelin Solda Giulia 2008 09 01 Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation Genome Research 18 9 1433 1445 doi 10 1101 gr 078378 108 ISSN 1088 9051 PMC 2527704 PMID 18562676 a b c d e Bell Charles C Amaral Paulo P Kalsbeek Anton Magor Graham W Gillinder Kevin R Tangermann Pierre Lisio Lorena di Cheetham Seth W Gruhl Franziska 2016 05 26 The Evx1 Evx1as gene locus regulates anterior posterior patterning during gastrulation Scientific Reports 6 26657 Bibcode 2016NatSR 626657B doi 10 1038 srep26657 ISSN 2045 2322 PMC 4880930 PMID 27226347 Kalisz Mark Winzi Maria Bisgaard Hanne Cathrine Serup Palle 2012 02 01 EVEN SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression Developmental Biology 362 1 94 103 doi 10 1016 j ydbio 2011 11 017 PMID 22178155 a b Moran Rivard Laura Kagawa Tetsushi Saueressig Harald Gross Michael K Burrill John Goulding Martyn 2001 02 01 Evx1 Is a Postmitotic Determinant of V0 Interneuron Identity in the Spinal Cord Neuron 29 2 385 399 doi 10 1016 S0896 6273 01 00213 6 ISSN 0896 6273 PMID 11239430 a b Luo Sai Lu J Yuyang Liu Lichao Yin Yafei Chen Chunyan Han Xue Wu Bohou Xu Ronggang Liu Wei 2016 05 05 Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells Cell Stem Cell 18 5 637 652 doi 10 1016 j stem 2016 01 024 ISSN 1934 5909 PMID 26996597 Retrieved from https en wikipedia org w index php title Evx1 amp oldid 1157165913, wikipedia, wiki, book, books, library,
