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Nucleated red blood cell

A nucleated red blood cell (NRBC), also known by several other names, is a red blood cell that contains a cell nucleus. Almost all vertebrate organisms have hemoglobin-containing cells in their blood, and with the exception of mammals, all of these red blood cells are nucleated.[1] In mammals, NRBCs occur in normal development as precursors to mature red blood cells in erythropoiesis, the process by which the body produces red blood cells.

A human peripheral blood smear; NRBCs are visible as larger cells with dark centers.

NRBCs are normally found in the bone marrow of humans of all ages and in the blood of fetuses and newborn infants.[2][3] After infancy, RBCs normally contain a nucleus only during the very early stages of the cell's life, and the nucleus is ejected as a normal part of cellular differentiation before the cell is released into the bloodstream. The presence of circulating NRBCs in adults occurs in situations of hematopoietic stress such as severe infection, massive hemorrhage, marrow infiltration, or extramedullary hematopoiesis.[4] That is, if NRBCs are identified on an adult's complete blood count or peripheral blood smear, it suggests that there is a very high demand for the bone marrow to produce RBCs, and immature RBCs are being released into circulation. Possible pathologic causes include anemia, myelofibrosis, thalassemia, miliary tuberculosis, cancers involving bone marrow (myelomas, leukemias, lymphomas), and in chronic hypoxemia.[5]

Nomenclature edit

 
Normocyte, Giemsa stain

Several names are used for nucleated RBCs—erythroblast, normoblast, and megaloblast—with one minor variation in word sense.[6][7][8][9] The name normoblast always refers to normal, healthy cells that are the immediate precursors of normal, healthy, mature (anucleate) RBCs. The name megaloblast always refers to abnormally developed precursors. Often the name erythroblast is used synonymously with normoblast, but at other times it is considered a hypernym. In the latter sense, there are two types of erythroblasts: normoblasts as cells that develop as expected, and megaloblasts as unusually large erythroblasts that are associated with illness.

Healthy development edit

There are four stages in the normal development of a normoblast.:

Illustration Description Image
  Pronormoblast
  Basophilic normoblast  
  Polychromatic normoblast (also polychromatophilic)  
  Orthochromatic normoblast (also orthochromatophilic)  

Pathogenesis edit

A megaloblast is an unusually large erythroblast that can be associated with vitamin B12 deficiency (caused by pernicious anemia or dietary insufficiency), folic acid deficiency, or both (such anemias are collectively called megaloblastic anemias). This kind of anemia leads to macrocytes (abnormally large red cells) and the condition called macrocytosis. The cause of this cellular gigantism is an impairment in DNA replication that delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony.

Additional images edit

See also edit

References edit

  1. ^ Hartenstein, V (2006). "Blood cells and blood cell development in the animal kingdom" (PDF). Annu Rev Cell Dev Biol. 22: 677–712. doi:10.1146/annurev.cellbio.22.010605.093317. PMID 16824014. Retrieved October 28, 2016.
  2. ^ Greer, JP; Arber, DA; Glader, BE; List, AF; Means, RM; Rodgers, GM (19 November 2018). "Chapter 1: Examination of the Blood and Bone Marrow, sec. "Nucleated Red Blood Cell Counts"". Wintrobe's Clinical Hematology (14th ed.). Wolters Kluwer Health. ISBN 978-1-4963-6713-6.
  3. ^ Kottke-Marchant, K; Davis, B (6 June 2012). Laboratory Hematology Practice. John Wiley & Sons. p. 294. ISBN 978-1-4443-9857-1.
  4. ^ Shehata, Amira M.F. (2020-09-30). "Clinical significance of nucleated red blood cell count in pediatric patients with transfusion-dependent beta thalassemia". Menoufia Medical Journal. 33 (3): 949–955.
  5. ^ Blood Smear: Details on RBCs, WBCs
  6. ^ "" at Dorland's Medical Dictionary
  7. ^ "" at Dorland's Medical Dictionary
  8. ^ "" at Dorland's Medical Dictionary
  9. ^ Normoblasts at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

External links edit

  • Pronormoblasts Presented by the University of Virginia
  • Basophilic Normoblasts Presented by the University of Virginia
  • Polychromatophilic Normoblasts Presented by the University of Virginia
  • Orthochromatic Normoblasts Presented by the University of Virginia
  • Histology image: 01804loa – Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "

nucleated, blood, cell, nucleated, blood, cell, nrbc, also, known, several, other, names, blood, cell, that, contains, cell, nucleus, almost, vertebrate, organisms, have, hemoglobin, containing, cells, their, blood, with, exception, mammals, these, blood, cell. A nucleated red blood cell NRBC also known by several other names is a red blood cell that contains a cell nucleus Almost all vertebrate organisms have hemoglobin containing cells in their blood and with the exception of mammals all of these red blood cells are nucleated 1 In mammals NRBCs occur in normal development as precursors to mature red blood cells in erythropoiesis the process by which the body produces red blood cells A human peripheral blood smear NRBCs are visible as larger cells with dark centers NRBCs are normally found in the bone marrow of humans of all ages and in the blood of fetuses and newborn infants 2 3 After infancy RBCs normally contain a nucleus only during the very early stages of the cell s life and the nucleus is ejected as a normal part of cellular differentiation before the cell is released into the bloodstream The presence of circulating NRBCs in adults occurs in situations of hematopoietic stress such as severe infection massive hemorrhage marrow infiltration or extramedullary hematopoiesis 4 That is if NRBCs are identified on an adult s complete blood count or peripheral blood smear it suggests that there is a very high demand for the bone marrow to produce RBCs and immature RBCs are being released into circulation Possible pathologic causes include anemia myelofibrosis thalassemia miliary tuberculosis cancers involving bone marrow myelomas leukemias lymphomas and in chronic hypoxemia 5 Contents 1 Nomenclature 2 Healthy development 3 Pathogenesis 4 Additional images 5 See also 6 References 7 External linksNomenclature edit nbsp Normocyte Giemsa stainSeveral names are used for nucleated RBCs erythroblast normoblast and megaloblast with one minor variation in word sense 6 7 8 9 The name normoblast always refers to normal healthy cells that are the immediate precursors of normal healthy mature anucleate RBCs The name megaloblast always refers to abnormally developed precursors Often the name erythroblast is used synonymously with normoblast but at other times it is considered a hypernym In the latter sense there are two types of erythroblasts normoblasts as cells that develop as expected and megaloblasts as unusually large erythroblasts that are associated with illness Healthy development editThere are four stages in the normal development of a normoblast Illustration Description Image nbsp Pronormoblast nbsp Basophilic normoblast nbsp nbsp Polychromatic normoblast also polychromatophilic nbsp nbsp Orthochromatic normoblast also orthochromatophilic nbsp Pathogenesis editA megaloblast is an unusually large erythroblast that can be associated with vitamin B12 deficiency caused by pernicious anemia or dietary insufficiency folic acid deficiency or both such anemias are collectively called megaloblastic anemias This kind of anemia leads to macrocytes abnormally large red cells and the condition called macrocytosis The cause of this cellular gigantism is an impairment in DNA replication that delays nuclear maturation and cell division Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells impaired DNA synthesis the cells show nuclear cytoplasmic asynchrony Additional images edit nbsp Blood cell lineage nbsp HematopoiesisSee also editErythropoiesis Haematopoiesis Hematopoietic stem cellReferences edit Hartenstein V 2006 Blood cells and blood cell development in the animal kingdom PDF Annu Rev Cell Dev Biol 22 677 712 doi 10 1146 annurev cellbio 22 010605 093317 PMID 16824014 Retrieved October 28 2016 Greer JP Arber DA Glader BE List AF Means RM Rodgers GM 19 November 2018 Chapter 1 Examination of the Blood and Bone Marrow sec Nucleated Red Blood Cell Counts Wintrobe s Clinical Hematology 14th ed Wolters Kluwer Health ISBN 978 1 4963 6713 6 Kottke Marchant K Davis B 6 June 2012 Laboratory Hematology Practice John Wiley amp Sons p 294 ISBN 978 1 4443 9857 1 Shehata Amira M F 2020 09 30 Clinical significance of nucleated red blood cell count in pediatric patients with transfusion dependent beta thalassemia Menoufia Medical Journal 33 3 949 955 Blood Smear Details on RBCs WBCs Erythroblast at Dorland s Medical Dictionary Normoblast at Dorland s Medical Dictionary Megaloblast at Dorland s Medical Dictionary Normoblasts at the U S National Library of Medicine Medical Subject Headings MeSH External links editPronormoblasts Presented by the University of Virginia Basophilic Normoblasts Presented by the University of Virginia Polychromatophilic Normoblasts Presented by the University of Virginia Orthochromatic Normoblasts Presented by the University of Virginia Histology image 01804loa Histology Learning System at Boston University Bone Marrow and Hemopoiesis bone marrow smear erythroblast series with proerythroblast Histology at uiowa edu Retrieved from https en wikipedia org w index php title Nucleated red blood cell amp oldid 1165919333, wikipedia, wiki, book, books, library,

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