Erinacines are natural substances isolated from Hericium erinaceus. They belong to the group of cyathinditerpenoids (erinacines A-K, P, and Q) and are subjects of pharmacological research.
Erinacine A, isolated from the cultured mycelia of Hericium erinaceus, the main representative of this compounds group, has an enhancing effect on nerve growth factor synthesis in vitro.[1] It also increases catecholamine in the central nervous system of rats.[citation needed] Hericenones and erinacines were isolated from the fruiting body and mycelium of H. erinaceus, respectively, and most of the compounds promote NGF biosynthesis in rodent cultured astrocytes. Among its active compounds, only erinacine A has confirmed pharmacological actions in the central nervous system in rats. Hence, this review has summarized the available information on the neurohealth properties of H. erinaceus mycelia enriched with erinacines, which may contribute to further research on the therapeutic roles of these mycelia. The safety of this mushroom has also been discussed. Although it has been difficult to extrapolate the in vivo studies to clinical situations, preclinical studies have shown that there can be improvements in ischemic stroke, Parkinson's disease, Alzheimer's disease, and depression if H. erinaceus mycelia enriched with erinacines are included in daily meals. Decreased levels of proinflammatory cytokines and inducible NO synthase (iNOS), however, have been detected in ischemic neurons after mycelia exposure.
^Hirokazu Kawagishi; Atsushi Shimada; Ryoko Shirai; Kenji Okamoto; Fumihiro Ojima; Hideki Sakamoto; Yukio Ishiguro; Shoei Furukawa (1994). "Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum". Tetrahedron Letters. 35 (10): 1569–1572. doi:10.1016/S0040-4039(00)76760-8.
^Barry B. Snider; Nha Huu Vo; Steven V. O'Neil & Bruce M. Foxman (1996). "Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A". J. Am. Chem. Soc. 118 (32): 7644–7645. doi:10.1021/ja9615379.
^Saito T, Aoki F, Hirai H, et al. (November 1998). "Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum". The Journal of Antibiotics. 51 (11): 983–90. doi:10.7164/antibiotics.51.983. PMID 9918390.
Further reading
Kenmoku H, Shimai T, Toyomasu T, Kato N, Sassa T (March 2002). "Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete". Bioscience, Biotechnology, and Biochemistry. 66 (3): 571–5. doi:10.1271/bbb.66.571. PMID 12005051.
January 29, 2023
erinacine, natural, substances, isolated, from, hericium, erinaceus, they, belong, group, cyathin, diterpenoids, erinacines, subjects, pharmacological, research, chemical, structures, erinacines, contents, references, further, reading, edit, isolated, from, cu. Erinacines are natural substances isolated from Hericium erinaceus They belong to the group of cyathin diterpenoids erinacines A K P and Q and are subjects of pharmacological research Chemical structures of erinacines A I Contents 1 Erinacine A 2 Erinacine E 3 References 4 Further readingErinacine A EditErinacine A isolated from the cultured mycelia of Hericium erinaceus the main representative of this compounds group has an enhancing effect on nerve growth factor synthesis in vitro 1 It also increases catecholamine in the central nervous system of rats citation needed Hericenones and erinacines were isolated from the fruiting body and mycelium of H erinaceus respectively and most of the compounds promote NGF biosynthesis in rodent cultured astrocytes Among its active compounds only erinacine A has confirmed pharmacological actions in the central nervous system in rats Hence this review has summarized the available information on the neurohealth properties of H erinaceus mycelia enriched with erinacines which may contribute to further research on the therapeutic roles of these mycelia The safety of this mushroom has also been discussed Although it has been difficult to extrapolate the in vivo studies to clinical situations preclinical studies have shown that there can be improvements in ischemic stroke Parkinson s disease Alzheimer s disease and depression if H erinaceus mycelia enriched with erinacines are included in daily meals Decreased levels of proinflammatory cytokines and inducible NO synthase iNOS however have been detected in ischemic neurons after mycelia exposure Erinacine A has also been prepared by total synthesis 2 Erinacine E EditErinacine E is a kappa opioid receptor agonist 3 References Edit Hirokazu Kawagishi Atsushi Shimada Ryoko Shirai Kenji Okamoto Fumihiro Ojima Hideki Sakamoto Yukio Ishiguro Shoei Furukawa 1994 Erinacines A B and C strong stimulators of nerve growth factor NGF synthesis from the mycelia of Hericium erinaceum Tetrahedron Letters 35 10 1569 1572 doi 10 1016 S0040 4039 00 76760 8 Barry B Snider Nha Huu Vo Steven V O Neil amp Bruce M Foxman 1996 Synthesis of Allocyathin B2 and Erinacine A J Am Chem Soc 118 32 7644 7645 doi 10 1021 ja9615379 Saito T Aoki F Hirai H et al November 1998 Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete Hericium ramosum The Journal of Antibiotics 51 11 983 90 doi 10 7164 antibiotics 51 983 PMID 9918390 Further reading EditKenmoku H Shimai T Toyomasu T Kato N Sassa T March 2002 Erinacine Q a new erinacine from Hericium erinaceum and its biosynthetic route to erinacine C in the basidiomycete Bioscience Biotechnology and Biochemistry 66 3 571 5 doi 10 1271 bbb 66 571 PMID 12005051 Retrieved from https en wikipedia org w index php title Erinacine amp oldid 1058794738, wikipedia, wiki, book, books, library,
