Erin Schuman attended the University of Southern California (USC), where she received her B.A. in Psychology (1985). She continued her education to obtain a Ph.D. in Neuroscience from Princeton University (1990). She conducted postdoctoral research from 1990–1993 in Daniel V. Madison’s lab in the Molecular and Cellular Physiology Department at Stanford University. From there, Schuman was recruited to join the faculty in the Division of Biology at the California Institute of Technology where she moved up the ranks from Assistant to Full Professor. During this time, she was also appointed investigator at the Howard Hughes Medical Institute. In 2009, she was recruited as the Director of Max Planck Institute for Brain Research in Frankfurt am Main, Germany, at which she holds her current position.[2]
Researchedit
The Schuman lab studies the properties of mRNAs and proteins (e.g. the transcriptomes and proteomes) distributed throughout the neuron.[3] Her research has examined how stability in neuronal processes can be brought about by local cell biological processes, like protein synthesis, allowing synapses to respond rapidly and appropriately to changing stimuli. The Schuman lab demonstrated the first functional role for local translation in neurons. In 1996, in the course of exploring how neurotrophins enhance synaptic transmission, Schuman together with graduate student Hyejin Kang made the discovery that local protein synthesis within dendrites is required for this form of synaptic plasticity.[4] She obtained direct proof that protein synthesis occurs in intact, isolated dendrites.[5] This, together with a few other key observations, gave birth to the field of local translation. Her team discovered, using next generation sequencing, over 2500 mRNAs localized to the neuropil.[6] In addition, Schuman and collaborators (Dave Tirrell, Caltech[7] and Daniela Dieterich, Magdeburg[8]) has made invaluable technical contributions, such as the development of non-canonical amino acid metabolic labelling, click chemistry, and mutation of cell-biological enzymes (the BONCAT and FUNCAT techniques), enabling the labelling, purification, identification and visualization of newly synthesized proteins in neurons and other cells.[9][10][11][12]
Advocacy for women in neuroscienceedit
In addition to her research and professorship, Erin Schuman has been committed to promoting the professional advancement of women in the field of neuroscience. Schuman made it a condition of her recruitment to Max Planck that a new child care facility be built on campus. She also spearheaded an initiative outlining changes in recruitment practices aimed at doubling the percentage of female directors in the Max Planck Society's Biology & Medicine Section to 20% by 2020. In 2018, she received the Society for Neuroscience Mika Salpeter Lifetime Achievement Award in for her teaching, mentoring, and advocacy.[13]
^Kang, Hyejin; Schuman, Erin M. (6 September 1996). "A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity". Science. 273 (5280): 1402–1406. Bibcode:1996Sci...273.1402K. doi:10.1126/science.273.5280.1402. ISSN 0036-8075. PMID 8703078. S2CID 38648558.
^Aakalu, Girish; Smith, W. Bryan; Nguyen, Nhien; Jiang, Changan; Schuman, Erin M. (1 May 2001). "Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons". Neuron. 30 (2): 489–502. doi:10.1016/S0896-6273(01)00295-1. ISSN 0896-6273. PMID 11395009. S2CID 18498839.
^Cajigas, Iván J.; Tushev, Georgi; Will, Tristan J.; tom Dieck, Susanne; Fuerst, Nicole; Schuman, Erin M. (May 2012). "The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging". Neuron. 74 (3): 453–466. doi:10.1016/j.neuron.2012.02.036. PMC3627340. PMID 22578497.
^"Reinterpreting the Genetic Code: Non-Canonical Amino Acids in Protein Design, Evolution and Analysis - Caltech Tirrell Lab". tirrell-lab.caltech.edu.
^Dieterich, D. C.; Link, A. J.; Graumann, J.; Tirrell, D. A.; Schuman, E. M. (12 June 2006). "Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)". Proceedings of the National Academy of Sciences. 103 (25): 9482–9487. Bibcode:2006PNAS..103.9482D. doi:10.1073/pnas.0601637103. ISSN 0027-8424. PMC1480433. PMID 16769897.
^Ngo, John T; Champion, Julie A; Mahdavi, Alborz; Tanrikulu, I Caglar; Beatty, Kimberly E; Connor, Rebecca E; Yoo, Tae Hyeon; Dieterich, Daniela C; Schuman, Erin M; Tirrell, David A (9 August 2009). "Cell-selective metabolic labeling of proteins". Nature Chemical Biology. 5 (10): 715–717. doi:10.1038/nchembio.200. PMC3176724. PMID 19668194.
^Dieterich, Daniela C; Hodas, Jennifer J L; Gouzer, Géraldine; Shadrin, Ilya Y; Ngo, John T; Triller, Antoine; Tirrell, David A; Schuman, Erin M (13 June 2010). "In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons". Nature Neuroscience. 13 (7): 897–905. doi:10.1038/nn.2580. PMC2920597. PMID 20543841.
^tom Dieck, Susanne; Kochen, Lisa; Hanus, Cyril; Heumüller, Maximilian; Bartnik, Ina; Nassim-Assir, Belquis; Merk, Katrin; Mosler, Thorsten; Garg, Sakshi; Bunse, Stefanie; Tirrell, David A; Schuman, Erin M (16 March 2015). "Direct visualization of newly synthesized target proteins in situ". Nature Methods. 12 (5): 411–414. doi:10.1038/nmeth.3319. PMC4414919. PMID 25775042.
^"Erin Schuman has been awarded the Mika Salpeter Lifetime Achievement Award". brain.mpg.de.
The Remarkable Neuron: Erin Schuman at TEDxCaltech on YouTube
November 28, 2023
erin, schuman, erin, margaret, schuman, born, 1963, california, neurobiologist, studies, neuronal, synapses, currently, director, planck, institute, brain, research, born, 1963, 1963, californiaalma, materuniversity, southern, california, princeton, university. Erin Margaret Schuman born May 15 1963 in California US is a neurobiologist who studies neuronal synapses She is currently a Director at the Max Planck Institute for Brain Research 1 Erin SchumanBorn 1963 05 15 May 15 1963 age 60 CaliforniaAlma materUniversity of Southern California Princeton UniversityKnown forLocal protein synthesis in dendritesAwardsBeckman Young Investigators Award 1996 Salpeter Lifetime Achievement Award 2018 Louis Jeantet Prize for Medicine 2020 Rosenstiel Award 2022 The Brain Prize 2023 Scientific careerInstitutionsMax Planck Institute for Brain Research California Institute of Technology Contents 1 Career 2 Research 3 Advocacy for women in neuroscience 4 Awards and recognition 5 References 6 External linksCareer editErin Schuman attended the University of Southern California USC where she received her B A in Psychology 1985 She continued her education to obtain a Ph D in Neuroscience from Princeton University 1990 She conducted postdoctoral research from 1990 1993 in Daniel V Madison s lab in the Molecular and Cellular Physiology Department at Stanford University From there Schuman was recruited to join the faculty in the Division of Biology at the California Institute of Technology where she moved up the ranks from Assistant to Full Professor During this time she was also appointed investigator at the Howard Hughes Medical Institute In 2009 she was recruited as the Director of Max Planck Institute for Brain Research in Frankfurt am Main Germany at which she holds her current position 2 Research editThe Schuman lab studies the properties of mRNAs and proteins e g the transcriptomes and proteomes distributed throughout the neuron 3 Her research has examined how stability in neuronal processes can be brought about by local cell biological processes like protein synthesis allowing synapses to respond rapidly and appropriately to changing stimuli The Schuman lab demonstrated the first functional role for local translation in neurons In 1996 in the course of exploring how neurotrophins enhance synaptic transmission Schuman together with graduate student Hyejin Kang made the discovery that local protein synthesis within dendrites is required for this form of synaptic plasticity 4 She obtained direct proof that protein synthesis occurs in intact isolated dendrites 5 This together with a few other key observations gave birth to the field of local translation Her team discovered using next generation sequencing over 2500 mRNAs localized to the neuropil 6 In addition Schuman and collaborators Dave Tirrell Caltech 7 and Daniela Dieterich Magdeburg 8 has made invaluable technical contributions such as the development of non canonical amino acid metabolic labelling click chemistry and mutation of cell biological enzymes the BONCAT and FUNCAT techniques enabling the labelling purification identification and visualization of newly synthesized proteins in neurons and other cells 9 10 11 12 Advocacy for women in neuroscience editIn addition to her research and professorship Erin Schuman has been committed to promoting the professional advancement of women in the field of neuroscience Schuman made it a condition of her recruitment to Max Planck that a new child care facility be built on campus She also spearheaded an initiative outlining changes in recruitment practices aimed at doubling the percentage of female directors in the Max Planck Society s Biology amp Medicine Section to 20 by 2020 In 2018 she received the Society for Neuroscience Mika Salpeter Lifetime Achievement Award in for her teaching mentoring and advocacy 13 Awards and recognition editSelected awards 14 2023 The Brain Prize 15 2022 Rosenstiel Award 16 2020 Louis Jeantet Prize for Medicine 17 2018 Society for Neuroscience Salpeter Lifetime Achievement Award 2017 Elected Member Academia Europaea 2017 Elected Member German National Academy of Sciences Leopoldina 18 2017 European Research Council Advanced Investigator Grant 2016 Forbes Lectures Marine Biological Laboratory 2014 Elected EMBO member 2013 Alexander Cruickshank Lecture Gordon Research Conference 2013 Hodgkin Huxley Katz Prize 2013 Norbert Elsner Lecture German Neuroscience Society 2011 European Research Council Advanced Investigator Grant 2005 Howard Hughes Medical Institute Investigator 2002 Howard Hughes Medical Institute Associate Investigator 1997 Howard Hughes Medical Institute Assistant Investigator 1996 Ferguson Biology Undergraduate Teaching Prize 1996 1998 Beckman Young Investigator Award 1995 Ferguson Biology Graduate Teaching Prize 1995 American Association of University Women Emerging Scholar 1995 1999 Pew Biomedical Scholar 1994 1998 John Merck Scholar 1994 1996 Alfred P Sloan Research Fellow 1994 1996 McKnight Scholars Award declined 1991 Katherine McCormick Foundation fellow 1990 NIH postdoctoral fellowship 1986 NIH predoctoral fellow 1985 Phi Beta Kappa graduation with honors 1985 Sigma Xi Outstanding Undergraduate Research AwardReferences edit Archived copy PDF Archived from the original PDF on 2018 10 26 Retrieved 2018 10 26 a href Template Cite web html title Template Cite web cite web a CS1 maint archived copy as title link Archived copy PDF Archived from the original PDF on 2019 05 03 Retrieved 2019 05 03 a href Template Cite web html title Template Cite web cite web a CS1 maint archived copy as title link Schuman Department brain mpg de Kang Hyejin Schuman Erin M 6 September 1996 A Requirement for Local Protein Synthesis in Neurotrophin Induced Hippocampal Synaptic Plasticity Science 273 5280 1402 1406 Bibcode 1996Sci 273 1402K doi 10 1126 science 273 5280 1402 ISSN 0036 8075 PMID 8703078 S2CID 38648558 Aakalu Girish Smith W Bryan Nguyen Nhien Jiang Changan Schuman Erin M 1 May 2001 Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons Neuron 30 2 489 502 doi 10 1016 S0896 6273 01 00295 1 ISSN 0896 6273 PMID 11395009 S2CID 18498839 Cajigas Ivan J Tushev Georgi Will Tristan J tom Dieck Susanne Fuerst Nicole Schuman Erin M May 2012 The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High Resolution Imaging Neuron 74 3 453 466 doi 10 1016 j neuron 2012 02 036 PMC 3627340 PMID 22578497 Reinterpreting the Genetic Code Non Canonical Amino Acids in Protein Design Evolution and Analysis Caltech Tirrell Lab tirrell lab caltech edu Daniela Dieterich MSc Integrative Neuroscience Magdeburg www neuroscience magdeburg de Dieterich D C Link A J Graumann J Tirrell D A Schuman E M 12 June 2006 Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging BONCAT Proceedings of the National Academy of Sciences 103 25 9482 9487 Bibcode 2006PNAS 103 9482D doi 10 1073 pnas 0601637103 ISSN 0027 8424 PMC 1480433 PMID 16769897 Ngo John T Champion Julie A Mahdavi Alborz Tanrikulu I Caglar Beatty Kimberly E Connor Rebecca E Yoo Tae Hyeon Dieterich Daniela C Schuman Erin M Tirrell David A 9 August 2009 Cell selective metabolic labeling of proteins Nature Chemical Biology 5 10 715 717 doi 10 1038 nchembio 200 PMC 3176724 PMID 19668194 Dieterich Daniela C Hodas Jennifer J L Gouzer Geraldine Shadrin Ilya Y Ngo John T Triller Antoine Tirrell David A Schuman Erin M 13 June 2010 In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons Nature Neuroscience 13 7 897 905 doi 10 1038 nn 2580 PMC 2920597 PMID 20543841 tom Dieck Susanne Kochen Lisa Hanus Cyril Heumuller Maximilian Bartnik Ina Nassim Assir Belquis Merk Katrin Mosler Thorsten Garg Sakshi Bunse Stefanie Tirrell David A Schuman Erin M 16 March 2015 Direct visualization of newly synthesized target proteins in situ Nature Methods 12 5 411 414 doi 10 1038 nmeth 3319 PMC 4414919 PMID 25775042 Erin Schuman has been awarded the Mika Salpeter Lifetime Achievement Award brain mpg de CV Schuman The Brain Prize 2023 Rosenstiel Award 2022 Erin SCHUMAN Jeantet 20 January 2020 Erin Schuman German Academy of Sciences Leopoldina Retrieved 26 May 2021 External links edithttps brain mpg de research schuman department The Remarkable Neuron Erin Schuman at TEDxCaltech on YouTube Retrieved from https en wikipedia org w index php title Erin Schuman amp oldid 1181167822, wikipedia, wiki, book, books, library,
