Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified
August 23, 2023
Epstein–Barr virus positive diffuse large B-cell lymphoma, not otherwise specified (also termed: EBV positive diffuse large B cell lymphoma, NOS; EBV+ DLBCL, NOS; or EBV+ DLBCL) was initially termed in the WHO 2008 classification as Epstein–Barr virus-positive DLBCL of the elderly because it was a specific type of large B-celllymphoma that appeared to be limited to elderly (e.g. >50 years old) individuals.[1][2]: 369–370 [3] Since this 2008 WHO classification, however, the disorder has been diagnosed in much younger adults and children.[4] Accordingly, the WHO classification of 2016 renamed this order as EBV+ DLBCL, NOS.[5] The disease is also classified as one of numerous related and interrelated Epstein-Barr virus-associated lymphoproliferative diseases.[4]
This type of lymphoma is not associated with immunodeficiency.[2]: 369 Although reported almost exclusively in Asians, it is not confined to that population.[2]: 369 [6] The disease usually has an extranodal presentation, with or without lymph node involvement.[2]: 369
Morphologically, areas of necrosis are often seen[2]: 370 [3] as well as Reed–Sternberg-like cells.[2]: 370 [3] There are two subtypes: one with monotonous large cells, the other with numerous cell sizes as well as reactive cells, but different clinical behavior is not appreciated between these subtypes.[2]: 370 Morphological differential diagnosis is Hodgkin lymphoma.[2]: 370
Median survival 2 years, 25% 5-year survival.[2]: 369
^Swerdlow, Steven H.; International Agency for Research on Cancer; World Health Organization (2008). . World Health Organization classification of tumours. Vol. 2 (4th ed.). International Agency for Research on Cancer. ISBN9789283224310. Archived from the original on October 12, 2013.
^ abcdefghijJaffe ES, Harris NL, Vardiman JW, Campo E, Arber, DA (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN9780721600406.
^ abcAdam P, Bonzheim I, Fend F, Quintanilla-Martínez L (2011). "Epstein-Barr virus-positive diffuse large B-cell lymphomas of the elderly". Adv Anat Pathol. 18 (5): 349–55. doi:10.1097/PAP.0b013e318229bf08. PMID 21841405. S2CID 21320902.
^ abDojcinov SD, Fend F, Quintanilla-Martinez L (March 2018). "EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts". Pathogens (Basel, Switzerland). 7 (1): 28. doi:10.3390/pathogens7010028. PMC5874754. PMID 29518976.
^Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC4874220. PMID 26980727.
^Ok CY, Papathomas TG, Medeiros LJ, Young KH (2013). "EBV-positive diffuse large B-cell lymphoma of the elderly". Blood. 122 (3): 328–40. doi:10.1182/blood-2013-03-489708. PMC3779382. PMID 23649469.
August 23, 2023
epstein, barr, virus, positive, diffuse, large, cell, lymphoma, otherwise, specified, also, termed, positive, diffuse, large, cell, lymphoma, dlbcl, dlbcl, initially, termed, 2008, classification, epstein, barr, virus, positive, dlbcl, elderly, because, specif. Epstein Barr virus positive diffuse large B cell lymphoma not otherwise specified also termed EBV positive diffuse large B cell lymphoma NOS EBV DLBCL NOS or EBV DLBCL was initially termed in the WHO 2008 classification as Epstein Barr virus positive DLBCL of the elderly because it was a specific type of large B cell lymphoma that appeared to be limited to elderly e g gt 50 years old individuals 1 2 369 370 3 Since this 2008 WHO classification however the disorder has been diagnosed in much younger adults and children 4 Accordingly the WHO classification of 2016 renamed this order as EBV DLBCL NOS 5 The disease is also classified as one of numerous related and interrelated Epstein Barr virus associated lymphoproliferative diseases 4 EBV DLBCL NOS is usually CD20 positive and has clonal immunoglobulin gene rearrangement 2 380 Contents 1 Biology 2 See also 3 ReferencesBiology EditThis type of lymphoma is not associated with immunodeficiency 2 369 Although reported almost exclusively in Asians it is not confined to that population 2 369 6 The disease usually has an extranodal presentation with or without lymph node involvement 2 369 Morphologically areas of necrosis are often seen 2 370 3 as well as Reed Sternberg like cells 2 370 3 There are two subtypes one with monotonous large cells the other with numerous cell sizes as well as reactive cells but different clinical behavior is not appreciated between these subtypes 2 370 Morphological differential diagnosis is Hodgkin lymphoma 2 370 Median survival 2 years 25 5 year survival 2 369 See also EditLymphomaReferences Edit Swerdlow Steven H International Agency for Research on Cancer World Health Organization 2008 WHO classification of tumours of haematopoietic and lymphoid tissues World Health Organization classification of tumours Vol 2 4th ed International Agency for Research on Cancer ISBN 9789283224310 Archived from the original on October 12 2013 a b c d e f g h i j Jaffe ES Harris NL Vardiman JW Campo E Arber DA 2011 Hematopathology 1st ed Elsevier Saunders ISBN 9780721600406 a b c Adam P Bonzheim I Fend F Quintanilla Martinez L 2011 Epstein Barr virus positive diffuse large B cell lymphomas of the elderly Adv Anat Pathol 18 5 349 55 doi 10 1097 PAP 0b013e318229bf08 PMID 21841405 S2CID 21320902 a b Dojcinov SD Fend F Quintanilla Martinez L March 2018 EBV Positive Lymphoproliferations of B T and NK Cell Derivation in Non Immunocompromised Hosts Pathogens Basel Switzerland 7 1 28 doi 10 3390 pathogens7010028 PMC 5874754 PMID 29518976 Swerdlow SH Campo E Pileri SA Harris NL Stein H Siebert R Advani R Ghielmini M Salles GA Zelenetz AD Jaffe ES May 2016 The 2016 revision of the World Health Organization classification of lymphoid neoplasms Blood 127 20 2375 90 doi 10 1182 blood 2016 01 643569 PMC 4874220 PMID 26980727 Ok CY Papathomas TG Medeiros LJ Young KH 2013 EBV positive diffuse large B cell lymphoma of the elderly Blood 122 3 328 40 doi 10 1182 blood 2013 03 489708 PMC 3779382 PMID 23649469 Retrieved from https en wikipedia org w index php title Epstein Barr virus positive diffuse large B cell lymphoma not otherwise specified amp oldid 1083129988, wikipedia, wiki, book, books, library,
