Elaine Sarkin Jaffe (born in August 1943) is a senior National Cancer Institute (NCI) investigator at the National Institutes of Health (NIH) most well known for her contribution to hematopathology. She completed her medical education at Cornell University and the University of Pennsylvania, receiving her M.D. degree from University of Pennsylvania in 1969.[1] After an internship at Georgetown University she joined NCI as a resident in anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphomas.[2] Jaffe's early work helped to provide a deeper understanding of the origin of lymphomas, especially follicular lymphoma. Her team notably elucidated the difference between T cell and B cell lymphomas.[3]
Her lab's findings led to the development of the WHO Classification of Tumours of the Hematopoietic and Lymphoid Tissues.[4] Jaffe was the President of the Society of Hematopathology at the time that the WHO's Revised European-American Classification of Lymphoid Neoplasms (REAL) classification system was developed in 1994; the REAL classification system is now considered the gold standard in hematopathology.[5] Today, her research includes genetic and epigenetic studies aimed at understanding how B-cells become Hodgkin's lymphoma cells, particularly through the lens of the microenvironment.[2] Jaffe's research has led to improvements in cancer treatments, including disease-specific therapies and improved clinical outcomes.[6]
Jaffe is the daughter of Ukrainian immigrants who fled Russia during World War I.[3] As a child in White Plains, New York, Jaffe was drawn to the sciences, particularly astronomy and geology. In an interview she states, "I fell in love with biology and decided in high school that I was going to become a doctor."[6] She received her undergraduate degree from Cornell University, and completed her medical education at the University of Pennsylvania in the late 1960s, where she was one of only five women in a class of more than 100 medical students.[6]
In her second year of medical school, she met and married her husband Michael Evan Jaffe, then a law student. Jaffe and her husband have two sons, Greg—an award-winning journalist at The Washington Post, formerly a reporter at the Wall Street Journal—and Caleb—a law professor at the University of Virginia Law School, formerly the director of the Virginia office of the Southern Environmental Law Center in Charlottesville, Virginia.
Jaffe, her husband and first child moved to the Washington, D.C. area, where the Jaffes' second son was born. Jaffe took a residency position at Georgetown University and worked primarily in anatomic pathology. After a year at Georgetown, Jaffe entered an NCI residency program. Jaffe's early research at NCI helped replace purely descriptive classifications with those based on immunology which helped in the development process leading to today's disease-specific therapies. Jaffe and her fellow NCI researchers showed that red blood cells coated with antibody and erythrocyte-antibody-complement (EAC) adhered to B-cell areas, proving they were lymphocytes derived from the lymphoid follicles.[6]
Honors and awardsedit
Jaffe has served on the editorial boards of the American Journal of Pathology, the American Journal of Surgical Pathology, Blood, Cancer Research, and Modern Pathology.[6] She has also served as president of the Society for Hematopathology[6] and the United States and Canadian Academy of Pathology (USCAP) (from 1998 to 1999).[7] In 1993, Jaffe was elected a fellow of the American Association for the Advancement of Science (AAAS). In 2005 she was chair of the Medical Sciences Section of AAAS and in 2007 she was the second Anita Roberts Lecturer at the NIH.[6] Jaffe is considered one of the most-cited researchers in clinical medicine by Science Watch and was among the top 10 in oncology between 1981 and 1998.[6] She is an elected member of the Institute of Medicine.[6]
^"Elain S. Jaffe, M.D." ccr.cancer.gov. Retrieved 13 March 2015.
^ ab"Elaine S. Jaffee, MD Senior Investigator Laboratory of Pathology". ccr.cancer.gov. Retrieved 13 March 2015.
^ ab. pathsoc.org. National Institutes of Health. Archived from the original on 14 September 2017. Retrieved 13 March 2015.
^"Lymphoma Disease Discovery and Definition". ccr.cancer.gov. Retrieved 13 March 2015.
^Delgado, Cynthia. . nih.gov. Archived from the original on 5 April 2014. Retrieved 13 March 2015.
^ abcdefghijklmnopPiana, Ronald. . cancernetwork.com. Cancer Network home of the journal ONCOLOGY. Archived from the original on 4 March 2016. Retrieved 13 March 2015.
^United States & Canadian Academy of Pathology. "Hall of Presidents, Elaine Sarkin Jaffe". Archived from the original on 15 March 2015. Retrieved 15 March 2015.
^"ASIP Rous-Whipple Award". American Society for Investigative Pathology.
May 05, 2024
elaine, jaffe, elaine, sarkin, jaffe, born, august, 1943, senior, national, cancer, institute, investigator, national, institutes, health, most, well, known, contribution, hematopathology, completed, medical, education, cornell, university, university, pennsyl. Elaine Sarkin Jaffe born in August 1943 is a senior National Cancer Institute NCI investigator at the National Institutes of Health NIH most well known for her contribution to hematopathology She completed her medical education at Cornell University and the University of Pennsylvania receiving her M D degree from University of Pennsylvania in 1969 1 After an internship at Georgetown University she joined NCI as a resident in anatomic pathology and has been a senior investigator since 1974 focusing on the classification and definition of lymphomas 2 Jaffe s early work helped to provide a deeper understanding of the origin of lymphomas especially follicular lymphoma Her team notably elucidated the difference between T cell and B cell lymphomas 3 Elaine S JaffeAlma materCornell University University of PennsylvaniaKnown forClassification of Lymphomas President of the Society for Hematopathology Fellow of the American Association for the Advancement of ScienceScientific careerFieldsHematopathology Cancer research leukemia amp lymphoma InstitutionsNational Cancer Institute Her lab s findings led to the development of the WHO Classification of Tumours of the Hematopoietic and Lymphoid Tissues 4 Jaffe was the President of the Society of Hematopathology at the time that the WHO s Revised European American Classification of Lymphoid Neoplasms REAL classification system was developed in 1994 the REAL classification system is now considered the gold standard in hematopathology 5 Today her research includes genetic and epigenetic studies aimed at understanding how B cells become Hodgkin s lymphoma cells particularly through the lens of the microenvironment 2 Jaffe s research has led to improvements in cancer treatments including disease specific therapies and improved clinical outcomes 6 Contents 1 Early life and career development 2 Honors and awards 2 1 Awards 3 See also 4 ReferencesEarly life and career development editJaffe is the daughter of Ukrainian immigrants who fled Russia during World War I 3 As a child in White Plains New York Jaffe was drawn to the sciences particularly astronomy and geology In an interview she states I fell in love with biology and decided in high school that I was going to become a doctor 6 She received her undergraduate degree from Cornell University and completed her medical education at the University of Pennsylvania in the late 1960s where she was one of only five women in a class of more than 100 medical students 6 In her second year of medical school she met and married her husband Michael Evan Jaffe then a law student Jaffe and her husband have two sons Greg an award winning journalist at The Washington Post formerly a reporter at the Wall Street Journal and Caleb a law professor at the University of Virginia Law School formerly the director of the Virginia office of the Southern Environmental Law Center in Charlottesville Virginia Jaffe her husband and first child moved to the Washington D C area where the Jaffes second son was born Jaffe took a residency position at Georgetown University and worked primarily in anatomic pathology After a year at Georgetown Jaffe entered an NCI residency program Jaffe s early research at NCI helped replace purely descriptive classifications with those based on immunology which helped in the development process leading to today s disease specific therapies Jaffe and her fellow NCI researchers showed that red blood cells coated with antibody and erythrocyte antibody complement EAC adhered to B cell areas proving they were lymphocytes derived from the lymphoid follicles 6 Honors and awards editJaffe has served on the editorial boards of the American Journal of Pathology the American Journal of Surgical Pathology Blood Cancer Research and Modern Pathology 6 She has also served as president of the Society for Hematopathology 6 and the United States and Canadian Academy of Pathology USCAP from 1998 to 1999 7 In 1993 Jaffe was elected a fellow of the American Association for the Advancement of Science AAAS In 2005 she was chair of the Medical Sciences Section of AAAS and in 2007 she was the second Anita Roberts Lecturer at the NIH 6 Jaffe is considered one of the most cited researchers in clinical medicine by Science Watchand was among the top 10 in oncology between 1981 and 1998 6 She is an elected member of the Institute of Medicine 6 Awards edit United States Public Health Service 6 nbsp Public Health Service Commendation Medal 1979 nbsp Public Health Service Meritorious Service Medal 1984 nbsp Public Health Service Outstanding Service Medal 1988 nbsp Surgeon General s Exemplary Service Medal 1993 nbsp Public Health Service Unit Commendation 1997 Fred W Stewart Award from Memorial Sloan Kettering Cancer Center 6 F K Mostofi Distinguished Service Award from the United States and Canadian Academy of Pathology 2003 6 Distinguished Clinical Teacher award from the NIH Fellows Committee 6 National Cancer Institute Outstanding Mentor Award 2011 6 Doctorate Honoris Causa from the University of Barcelona 2008 6 Chugai Award for Excellence in Mentoring and Scholarship from the American Society for Investigative Pathology 6 Henry M Stratton Medal from the American Society of Hematology 2013 ASIP Rous Whipple Award from the American Society for Investigative Pathology 2016 8 See also editSurgical pathology Hematopathology List of pathologistsReferences edit Elain S Jaffe M D ccr cancer gov Retrieved 13 March 2015 a b Elaine S Jaffee MD Senior Investigator Laboratory of Pathology ccr cancer gov Retrieved 13 March 2015 a b Elaine Jaffe Transcript Summary pathsoc org National Institutes of Health Archived from the original on 14 September 2017 Retrieved 13 March 2015 Lymphoma Disease Discovery and Definition ccr cancer gov Retrieved 13 March 2015 Delgado Cynthia Elaine Jaffe Hercule Poirot in a Pathological Universe nih gov Archived from the original on 5 April 2014 Retrieved 13 March 2015 a b c d e f g h i j k l m n o p Piana Ronald Elaine Jaffe At the forefront of clinical lymphoma biology cancernetwork com Cancer Network home of the journal ONCOLOGY Archived from the original on 4 March 2016 Retrieved 13 March 2015 United States amp Canadian Academy of Pathology Hall of Presidents Elaine Sarkin Jaffe Archived from the original on 15 March 2015 Retrieved 15 March 2015 ASIP Rous Whipple Award American Society for Investigative Pathology Retrieved from https en wikipedia org w index php title Elaine Jaffe amp oldid 1211135606, wikipedia, wiki, book, books, library,
