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Edestin

January 01, 1970

Edestin, (also known as Edistin[1]) is a highly-digestible, hexameric legumin protein with six subunits, [2][3][4] and a seed storage protein,[5] with a molecular weight of 310 kDa.[6] This protein is primarily found in hemp seeds.[2] Edestin is a globular protein (biologically active) as opposed to fibrous protein (structural).


Globular proteins found in edestin (and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins, and Gamma globulins) are long peptide chains, precursors for biological proteins essential for life. Edestin is similar to serum globulin (blood plasma), and the biologically active protein of edestin is metabolized in the human body and capable of biosynthesizing:[7][8]

  • hormones (which regulate all the body processes),
  • hemoglobin (which transports oxygen, carbon dioxide, and nitric oxide),
  • enzymes (which catalyze and control biochemical reactions),
  • antibodies (immunoglobulins which fend off invading bacteria, viruses, and other pathogens, as well as toxins or antigens as they enter the body).

Edestin can also be broken down to edestan.[9]


Hemp seed edit

 
A close look at a hemp plant with dried-out seeds and leaves.

It has been discovered that there are seven cDNAs encoding edestin in Cannabis sativa L., the sequences are distinguished by globulin characteristic. There is a type 1 and type 2 of edestin that are both used in process of the development of hemp seeds. Edestin has been used to help the nutritional quality of plant consumption.[10]  Hemp seeds are considered to be fruits from hemp plants,[11] and can be used in several different methods: medicine, food, fiber, or psychoactive adjuvants.[12]

Commercial hemp seeds (for human consumption) contain an average 30-35% protein, of which 60-80% is edestin (the remainder being albumin).[13] A particular strain of Korean hemp, Cheungsam, because it contains 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, has been suggested for utilization as "a superior antioxidative nutrient".[7]

References edit

  1. ^ Möller G, Fernandez C (1978). "Immunological tolerance to the thymus-independent antigen dextran can be abrogated by thymus-dependent dextran conjugates: evidence against clonal deletion as the mechanism of tolerance induction". Scandinavian Journal of Immunology. 8 (1): 29–37. doi:10.1111/j.1365-3083.1978.tb00493.x. PMID 309173. S2CID 40616995.
  2. ^ a b Patel, Samit; Cudney, Robert; McPherson, Alexander (1994-01-07). "Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp". Journal of Molecular Biology. 235 (1): 361–363. doi:10.1016/S0022-2836(05)80040-3. ISSN 0022-2836. PMID 8289257. S2CID 30690679.
  3. ^ Patel S, Cudney R, McPherson A (January 1994). "Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp". J. Mol. Biol. 235 (1): 361–3. doi:10.1016/S0022-2836(05)80040-3. PMID 8289257. S2CID 30690679.
  4. ^ Chuan-He Tang (November 15, 2006). "Physicochemical and functional properties of hemp (Cannabis sativa L.) protein isolate". J Agric Food Chem. 54 (23): 8945–8950. doi:10.1021/jf0619176. PMID 17090145.
  5. ^ Teresa Docimo (September 24, 2014). "Molecular characterization of edestin gene family in Cannabis sativa L". Plant Physiology and Biochemistry. 84: 142–148. doi:10.1016/j.plaphy.2014.09.011. PMID 25280223.
  6. ^ "Protein - Proteins of the blood serum | Britannica".
  7. ^ a b Kim, Jum-Ji (2011), "Isolation and Characterization of Edestin from Cheungsam Hempseed", Journal of Applied Biological Chemistry, 54 (2): 84–88, doi:10.3839/jabc.2011.015
  8. ^ Tombs MP (1960). "A haemoglobin-binding beta-globulin in human serum". Nature. 186 (4730): 1055–6. Bibcode:1960Natur.186.1055T. doi:10.1038/1861055b0. PMID 13838734. S2CID 4213851.
  9. ^ Kenneth Bailey (January 29, 1942). "The denaturation of edestin by acid: T. B. Osborne's edestan". Biochemical Journal. 36 (1–2): 140–154. doi:10.1042/bj0360140. PMC 1265671. PMID 16747476.
  10. ^ Docimo, Teresa; Caruso, Immacolata; Ponzoni, Elena; Mattana, Monica; Galasso, Incoronata (2014-11-01). "Molecular characterization of edestin gene family in Cannabis sativa L." Plant Physiology and Biochemistry. 84: 142–148. doi:10.1016/j.plaphy.2014.09.011. ISSN 0981-9428. PMID 25280223.
  11. ^ Bhandwale, Guruprasad; Pujari, Sourabh; Kadam, Pradnya; Mantri, Shivani; Kulkarni, Poorva. "Evolutionary study of Edestin Protein in Cannabis Sativa L" (PDF). www.irjet.net.
  12. ^ Docimo, Teresa; Caruso, Immacolata; Ponzoni, Elena; Mattana, Monica; Galasso, Incoronata (2014-11-01). "Molecular characterization of edestin gene family in Cannabis sativa L." Plant Physiology and Biochemistry. 84: 142–148. doi:10.1016/j.plaphy.2014.09.011. ISSN 0981-9428. PMID 25280223.
  13. ^ Galasso, Incoronata (2016), "Variability in Seed Traits in a Collection of Cannabis sativa L. Genotypes", Frontiers in Plant Science, 7: 688, doi:10.3389/fpls.2016.00688, PMC 4873519, PMID 27242881


 

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January 01, 1970
edestin, also, known, edistin, highly, digestible, hexameric, legumin, protein, with, subunits, seed, storage, protein, with, molecular, weight, this, protein, primarily, found, hemp, seeds, globular, protein, biologically, active, opposed, fibrous, protein, s. Edestin also known as Edistin 1 is a highly digestible hexameric legumin protein with six subunits 2 3 4 and a seed storage protein 5 with a molecular weight of 310 kDa 6 This protein is primarily found in hemp seeds 2 Edestin is a globular protein biologically active as opposed to fibrous protein structural Globular proteins found in edestin and in Alpha 1 globulins Alpha 2 globulins Beta globulins and Gamma globulins are long peptide chains precursors for biological proteins essential for life Edestin is similar to serum globulin blood plasma and the biologically active protein of edestin is metabolized in the human body and capable of biosynthesizing 7 8 hormones which regulate all the body processes hemoglobin which transports oxygen carbon dioxide and nitric oxide enzymes which catalyze and control biochemical reactions antibodies immunoglobulins which fend off invading bacteria viruses and other pathogens as well as toxins or antigens as they enter the body Edestin can also be broken down to edestan 9 Hemp seed edit nbsp A close look at a hemp plant with dried out seeds and leaves It has been discovered that there are seven cDNAs encoding edestin in Cannabis sativa L the sequences are distinguished by globulin characteristic There is a type 1 and type 2 of edestin that are both used in process of the development of hemp seeds Edestin has been used to help the nutritional quality of plant consumption 10 Hemp seeds are considered to be fruits from hemp plants 11 and can be used in several different methods medicine food fiber or psychoactive adjuvants 12 Commercial hemp seeds for human consumption contain an average 30 35 protein of which 60 80 is edestin the remainder being albumin 13 A particular strain of Korean hemp Cheungsam because it contains 2 2 diphenyl 1 picrylhydrazyl DPPH free radical scavenging activity has been suggested for utilization as a superior antioxidative nutrient 7 References edit Moller G Fernandez C 1978 Immunological tolerance to the thymus independent antigen dextran can be abrogated by thymus dependent dextran conjugates evidence against clonal deletion as the mechanism of tolerance induction Scandinavian Journal of Immunology 8 1 29 37 doi 10 1111 j 1365 3083 1978 tb00493 x PMID 309173 S2CID 40616995 a b Patel Samit Cudney Robert McPherson Alexander 1994 01 07 Crystallographic characterization and molecular symmetry of edestin a legumin from hemp Journal of Molecular Biology 235 1 361 363 doi 10 1016 S0022 2836 05 80040 3 ISSN 0022 2836 PMID 8289257 S2CID 30690679 Patel S Cudney R McPherson A January 1994 Crystallographic characterization and molecular symmetry of edestin a legumin from hemp J Mol Biol 235 1 361 3 doi 10 1016 S0022 2836 05 80040 3 PMID 8289257 S2CID 30690679 Chuan He Tang November 15 2006 Physicochemical and functional properties of hemp Cannabis sativa L protein isolate J Agric Food Chem 54 23 8945 8950 doi 10 1021 jf0619176 PMID 17090145 Teresa Docimo September 24 2014 Molecular characterization of edestin gene family in Cannabis sativa L Plant Physiology and Biochemistry 84 142 148 doi 10 1016 j plaphy 2014 09 011 PMID 25280223 Protein Proteins of the blood serum Britannica a b Kim Jum Ji 2011 Isolation and Characterization of Edestin from Cheungsam Hempseed Journal of Applied Biological Chemistry 54 2 84 88 doi 10 3839 jabc 2011 015 Tombs MP 1960 A haemoglobin binding beta globulin in human serum Nature 186 4730 1055 6 Bibcode 1960Natur 186 1055T doi 10 1038 1861055b0 PMID 13838734 S2CID 4213851 Kenneth Bailey January 29 1942 The denaturation of edestin by acid T B Osborne s edestan Biochemical Journal 36 1 2 140 154 doi 10 1042 bj0360140 PMC 1265671 PMID 16747476 Docimo Teresa Caruso Immacolata Ponzoni Elena Mattana Monica Galasso Incoronata 2014 11 01 Molecular characterization of edestin gene family in Cannabis sativa L Plant Physiology and Biochemistry 84 142 148 doi 10 1016 j plaphy 2014 09 011 ISSN 0981 9428 PMID 25280223 Bhandwale Guruprasad Pujari Sourabh Kadam Pradnya Mantri Shivani Kulkarni Poorva Evolutionary study of Edestin Protein in Cannabis Sativa L PDF www irjet net Docimo Teresa Caruso Immacolata Ponzoni Elena Mattana Monica Galasso Incoronata 2014 11 01 Molecular characterization of edestin gene family in Cannabis sativa L Plant Physiology and Biochemistry 84 142 148 doi 10 1016 j plaphy 2014 09 011 ISSN 0981 9428 PMID 25280223 Galasso Incoronata 2016 Variability in Seed Traits in a Collection of Cannabis sativa L Genotypes Frontiers in Plant Science 7 688 doi 10 3389 fpls 2016 00688 PMC 4873519 PMID 27242881 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Edestin amp oldid 1140721669, wikipedia, wiki, book, books, library,

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