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Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis.[3] It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.[3] Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions.[3] It is produced in Chinese hamster ovary cells.[3]
^"Pulmozyme Product information". Health Canada. 25 April 2012. Retrieved 9 January 2023.
^ abcdef"Pulmozyme- dornase alfa solution". DailyMed. 21 October 2020. Retrieved 9 January 2023.
^Collier, Joe (1 September 1995). "Dornase-alfa and orphan drugs". The Lancet. 346 (8975): 633. doi:10.1016/S0140-6736(95)91460-9. PMID 7651014. S2CID 5456247.
^Erdeve O, Uras N, Atasay B, Arsan S (2007). "Efficacy and safety of nebulized recombinant human DNase as rescue treatment for persistent atelectasis in newborns: case-series". Croat Med J. 48 (2): 234–9. PMC2080511. PMID 17436388.
^Hendriks T, de Hoog M, Lequin MH, Devos AS, Merkus PJ (2005). "DNase and atelectasis in non-cystic fibrosis pediatric patients". Crit Care. 9 (4): R351-6. doi:10.1186/cc3544. PMC1269442. PMID 16137347.
dornase, alfa, this, article, needs, more, reliable, medical, references, verification, relies, heavily, primary, sources, please, review, contents, article, appropriate, references, unsourced, poorly, sourced, material, challenged, removed, find, sources, new. This article needs more reliable medical references for verification or relies too heavily on primary sources Please review the contents of the article and add the appropriate references if you can Unsourced or poorly sourced material may be challenged and removed Find sources Dornase alfa news newspapers books scholar JSTOR February 2022 Dornase alfa sold under the brand name Pulmozyme is used for the treatment of cystic fibrosis 3 It is a recombinant human deoxyribonuclease I rhDNase an enzyme which selectively cleaves DNA 3 Dornase alfa hydrolyzes the DNA present in sputum mucus and reduces viscosity in the lungs promoting improved clearance of secretions 3 It is produced in Chinese hamster ovary cells 3 Dornase alfaClinical dataTrade namesPulmozymeAHFS Drugs comMonographMedlinePlusa694002License dataUS DailyMed Dornase alfaPregnancycategoryAU B1 1 Routes ofadministrationInhalationATC codeR05CB13 WHO Legal statusLegal statusAU S4 Prescription only 1 CA only Schedule D 2 US only 3 In general Prescription only IdentifiersCAS Number143831 71 4 NDrugBankDB00003 YChemSpidernoneUNII953A26OA1YKEGGD03896CompTox Dashboard EPA DTXSID801010888ECHA InfoCard100 029 685Chemical and physical dataFormulaC 1321H 1999N 339O 396S 9Molar mass29254 04 g mol 1 N Y what is this verify Contents 1 Medical uses 2 Society and culture 2 1 Legal status 3 Research 4 ReferencesMedical uses editDornase alfa is indicated for the management of people with cystic fibrosis to improve pulmonary function 3 Society and culture editLegal status edit Dornase alfa is an orphan drug 4 Research editDornase alfa has been shown to improve lung function in non cystic fibrosis pre term infants atelectasis 5 6 References edit a b Product guildlink com au Pulmozyme Product information Health Canada 25 April 2012 Retrieved 9 January 2023 a b c d e f Pulmozyme dornase alfa solution DailyMed 21 October 2020 Retrieved 9 January 2023 Collier Joe 1 September 1995 Dornase alfa and orphan drugs The Lancet 346 8975 633 doi 10 1016 S0140 6736 95 91460 9 PMID 7651014 S2CID 5456247 Erdeve O Uras N Atasay B Arsan S 2007 Efficacy and safety of nebulized recombinant human DNase as rescue treatment for persistent atelectasis in newborns case series Croat Med J 48 2 234 9 PMC 2080511 PMID 17436388 Hendriks T de Hoog M Lequin MH Devos AS Merkus PJ 2005 DNase and atelectasis in non cystic fibrosis pediatric patients Crit Care 9 4 R351 6 doi 10 1186 cc3544 PMC 1269442 PMID 16137347 Portal nbsp Medicine Retrieved from https en wikipedia org w index php title Dornase alfa amp oldid 1188114017, wikipedia, wiki, book, books, library,
