Disulfide bond formation protein B (DsbB) is a protein component of the pathway that leads to disulfide bond formation in periplasmic proteins of Escherichia coli (P0A6M2) and other bacteria. In Bacillus subtilis it is known as BdbC (O32217).
Disulfide bond formation protein B (red), complex with DsbA (blue)
The DsbB protein oxidizes the periplasmic protein DsbA which in turn oxidizes cysteines in other periplasmic proteins in order to make disulfide bonds.[1] DsbB acts as a redox potential transducer across the cytoplasmic membrane. It is a membrane protein which spans the membrane four times with both the N- and C-termini of the protein are in the cytoplasm. Each of the periplasmic domains of the protein has two essential cysteines. The two cysteines in the first periplasmic domain are in a Cys-X-Y-Cys configuration that is characteristic of the active site of other proteins involved in disulfide bond formation, including DsbA and protein disulfide isomerase.[2]
^Lee JO, Beckwith J, Bardwell JC, Jander G, Martin N, Belin D (1993). "A pathway for disulfide bond formation in vivo". Proc. Natl. Acad. Sci. U.S.A. 90 (3): 1038–1042. Bibcode:1993PNAS...90.1038B. doi:10.1073/pnas.90.3.1038. PMC45806. PMID 8430071.
^Beckwith J, Jander G, Martin NL (1994). "Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation". EMBO J. 13 (21): 5121–5127. doi:10.1002/j.1460-2075.1994.tb06841.x. PMC395459. PMID 7957076.
This article incorporates text from the public domain Pfam and InterPro: IPR003752
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disulfide, bond, formation, protein, this, article, technical, most, readers, understand, please, help, improve, make, understandable, experts, without, removing, technical, details, june, 2012, learn, when, remove, this, template, message, dsbb, protein, comp. This article may be too technical for most readers to understand Please help improve it to make it understandable to non experts without removing the technical details June 2012 Learn how and when to remove this template message Disulfide bond formation protein B DsbB is a protein component of the pathway that leads to disulfide bond formation in periplasmic proteins of Escherichia coli P0A6M2 and other bacteria In Bacillus subtilis it is known as BdbC O32217 Disulfide bond formation protein B red complex with DsbA blue IdentifiersSymbolDsbBPfamPF02600InterProIPR003752TCDB5 A 2OPM superfamily173OPM protein2hi7Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryThe DsbB protein oxidizes the periplasmic protein DsbA which in turn oxidizes cysteines in other periplasmic proteins in order to make disulfide bonds 1 DsbB acts as a redox potential transducer across the cytoplasmic membrane It is a membrane protein which spans the membrane four times with both the N and C termini of the protein are in the cytoplasm Each of the periplasmic domains of the protein has two essential cysteines The two cysteines in the first periplasmic domain are in a Cys X Y Cys configuration that is characteristic of the active site of other proteins involved in disulfide bond formation including DsbA and protein disulfide isomerase 2 See also editDisulfide bond formation protein A Disulfide bond formation protein CReferences edit Lee JO Beckwith J Bardwell JC Jander G Martin N Belin D 1993 A pathway for disulfide bond formation in vivo Proc Natl Acad Sci U S A 90 3 1038 1042 Bibcode 1993PNAS 90 1038B doi 10 1073 pnas 90 3 1038 PMC 45806 PMID 8430071 Beckwith J Jander G Martin NL 1994 Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation EMBO J 13 21 5121 5127 doi 10 1002 j 1460 2075 1994 tb06841 x PMC 395459 PMID 7957076 This article incorporates text from the public domain Pfam and InterPro IPR003752 nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Disulfide bond formation protein B amp oldid 1040893218, wikipedia, wiki, book, books, library,
