The diffuse leprosy of Lucio and Latapí, also known as diffuse lepromatous leprosy or "pretty leprosy", is a clinical variety of lepromatous leprosy. It was first described by Lucio and Alvarado in 1852 and re-identified by Latapí in 1936. It is common in Mexico (23% of leprosy cases) and in Costa Rica and very rare in other countries.
The spotted or lazarine leprosy was first described by Ladislao de la Pascua in 1844.[1] Lucio and Alvarado published a description of the disease with the same names in 1852. Latapí re-described it in 1938 and reported it as 'spotted' leprosy of Lucio in 1948. It was named the diffuse leprosy of Lucio and Latapí in 1963 by Frenken.
The underlying pathology was explained by Chévez-Zamora as a diffuse generalised cutaneous infiltration. He named it pure and primitive diffuse lepromatosis, upon which necrotising lesions develop. He proposed the name Fenómeno de Lucio or erythema necrotisans for these lesions.
Lucio's phenomenon consists of well-shaped erythematous spots which later become necrotic with scabs, ulcerations and scars. These lesions are usually located on the lower extremities and may be extensive. They are frequently painful and rarely fatal.
Pathologyedit
The main pathological features of this disease are a vasculitis affecting all cutaneous vessels.
thrombosis of the superficial and mid-dermal blood vessels
The likely pathogenesis is endothelial cell injury due to colonization/invasion followed by proliferation, angiogenesis, thrombosis and vessel ectasia.
^ abVargas-Ocampo F (2007). "Diffuse leprosy of Lucio and Latapí: a histologic study". Leprosy Review. 78 (3): 248–260. doi:10.47276/lr.78.3.248. PMID 18035776.
^Saúl A; Novales J (1983). "Lucio-Latapí leprosy and the Lucio phenomenon". Acta Leprologica (in French). 1 (3): 115–132. PMID 6359800.
^Kasper DL, Braunwald E, Fauci AS, et al. Harrison's Principles of Internal Medicine. 16th edition. McGraw-Hill. 2005. Vol I. p.971. ISBN0071477608
April 09, 2024
diffuse, leprosy, lucio, latapí, diffuse, leprosy, lucio, latapí, also, known, diffuse, lepromatous, leprosy, pretty, leprosy, clinical, variety, lepromatous, leprosy, first, described, lucio, alvarado, 1852, identified, latapí, 1936, common, mexico, leprosy, . The diffuse leprosy of Lucio and Latapi also known as diffuse lepromatous leprosy or pretty leprosy is a clinical variety of lepromatous leprosy It was first described by Lucio and Alvarado in 1852 and re identified by Latapi in 1936 It is common in Mexico 23 of leprosy cases and in Costa Rica and very rare in other countries Contents 1 History 2 Clinical features 3 Pathology 4 Treatment 5 ReferencesHistory editThe spotted or lazarine leprosy was first described by Ladislao de la Pascua in 1844 1 Lucio and Alvarado published a description of the disease with the same names in 1852 Latapi re described it in 1938 and reported it as spotted leprosy of Lucio in 1948 It was named the diffuse leprosy of Lucio and Latapi in 1963 by Frenken The underlying pathology was explained by Chevez Zamora as a diffuse generalised cutaneous infiltration He named it pure and primitive diffuse lepromatosis upon which necrotising lesions develop He proposed the name Fenomeno de Lucio or erythema necrotisans for these lesions Clinical features editThis condition is characterized by 2 a diffuse infiltration of all the skin which never transforms into nodule a complete alopecia of eyebrows and eyelashes and body hair an anhydrotic and dysesthesic zones of the skin a peculiar type of lepra reaction named Lucio s phenomenon or necrotic erythemaLucio s phenomenon consists of well shaped erythematous spots which later become necrotic with scabs ulcerations and scars These lesions are usually located on the lower extremities and may be extensive They are frequently painful and rarely fatal Pathology editThe main pathological features of this disease are a vasculitis affecting all cutaneous vessels There are by five characteristic features 1 colonisation of endothelial cells by acid fast bacilli endothelial proliferation and marked thickening of vessel walls to the point of obliteration angiogenesis vascular ectasia thrombosis of the superficial and mid dermal blood vesselsThe likely pathogenesis is endothelial cell injury due to colonization invasion followed by proliferation angiogenesis thrombosis and vessel ectasia Treatment editLucio s phenomenon is treated by anti leprosy therapy dapsone rifampin and clofazimine optimal wound care and treatment for bacteremia including antibiotics In severe cases exchange transfusion may be helpful 3 References edit a b Vargas Ocampo F 2007 Diffuse leprosy of Lucio and Latapi a histologic study Leprosy Review 78 3 248 260 doi 10 47276 lr 78 3 248 PMID 18035776 Saul A Novales J 1983 Lucio Latapi leprosy and the Lucio phenomenon Acta Leprologica in French 1 3 115 132 PMID 6359800 Kasper DL Braunwald E Fauci AS et al Harrison s Principles of Internal Medicine 16th edition McGraw Hill 2005 Vol I p 971 ISBN 0071477608 Retrieved from https en wikipedia org w index php title Diffuse leprosy of Lucio and Latapi amp oldid 1190174998, wikipedia, wiki, book, books, library,
