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Diacylglycerol cholinephosphotransferase

In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction

diacylglycerol cholinephosphotransferase
Identifiers
EC no.2.7.8.2
CAS no.9026-13-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
CDP-choline + 1,2-diacylglycerol CMP + a phosphatidylcholine

Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.[1]

Classification edit

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.

Nomenclature edit

The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:

  • 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
  • 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
  • 1-alkyl-2-acetylglycerol cholinephosphotransferase,
  • alkylacylglycerol choline phosphotransferase,
  • alkylacylglycerol cholinephosphotransferase,
  • CDP-choline diglyceride phosphotransferase,
  • cholinephosphotransferase,
  • CPT,
  • cytidine diphosphocholine glyceride transferase,
  • cytidine diphosphorylcholine diglyceride transferase,
  • diacylglycerol choline phosphotransferase,
  • phosphocholine diacylglyceroltransferase,
  • phosphorylcholine-glyceride transferase, and
  • sn-1,2-diacylglycerol cholinephosphotransferase.

Biological role edit

This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References edit

  1. ^ Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities". J. Biol. Chem. 252 (9): 3050–6. PMID 192727.
  • Lee TC, Blank ML, Fitzgerald V, Snyder F (1982). "Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver". Biochim. Biophys. Acta. 713 (2): 479–83. doi:10.1016/0005-2760(82)90269-7. PMID 6295501.
  • Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ (1978). "Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate". Lipids. 13 (2): 161–4. doi:10.1007/BF02533260. PMID 204847.
  • Renooij W, Snyder F (1981). "Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues". Biochim. Biophys. Acta. 663 (2): 545–56. doi:10.1016/0005-2760(81)90182-x. PMID 6260215.


diacylglycerol, cholinephosphotransferase, enzymology, diacylglycerol, cholinephosphotransferase, enzyme, that, catalyzes, chemical, reactiondiacylglycerol, cholinephosphotransferaseidentifiersec, 2cas, 9026, 5databasesintenzintenz, viewbrendabrenda, entryexpa. In enzymology a diacylglycerol cholinephosphotransferase EC 2 7 8 2 is an enzyme that catalyzes the chemical reactiondiacylglycerol cholinephosphotransferaseIdentifiersEC no 2 7 8 2CAS no 9026 13 5DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins CDP choline 1 2 diacylglycerol displaystyle rightleftharpoons CMP a phosphatidylcholine Thus the two substrates of this enzyme are CDP choline and 1 2 diacylglycerol whereas its two products are CMP and phosphatidylcholine 1 Contents 1 Classification 2 Nomenclature 3 Biological role 4 ReferencesClassification editThis enzyme belongs to the family of transferases specifically those transferring non standard substituted phosphate groups Nomenclature editThe systematic name of this enzyme class is CDP choline 1 2 diacylglycerol cholinephosphotransferase Other names in common use include 1 alkyl 2 acetyl m glycerol CDPcholine choline phosphotransferase 1 alkyl 2 acetyl sn glycerol cholinephosphotransferase 1 alkyl 2 acetylglycerol cholinephosphotransferase alkylacylglycerol choline phosphotransferase alkylacylglycerol cholinephosphotransferase CDP choline diglyceride phosphotransferase cholinephosphotransferase CPT cytidine diphosphocholine glyceride transferase cytidine diphosphorylcholine diglyceride transferase diacylglycerol choline phosphotransferase phosphocholine diacylglyceroltransferase phosphorylcholine glyceride transferase and sn 1 2 diacylglycerol cholinephosphotransferase Biological role editThis enzyme participates in 3 metabolic pathways aminophosphonate metabolism glycerophospholipid metabolism and ether lipid metabolism References edit Coleman R Bell RM 1977 Phospholipid synthesis in isolated fat cells Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities J Biol Chem 252 9 3050 6 PMID 192727 Lee TC Blank ML Fitzgerald V Snyder F 1982 Formation of alkylacyl and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver Biochim Biophys Acta 713 2 479 83 doi 10 1016 0005 2760 82 90269 7 PMID 6295501 Parthasarathy S Cady RK Kraushaar DS Sladek NE Baumann WJ 1978 Inhibition of diacylglycerol CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p chlorophenoxyacetate Lipids 13 2 161 4 doi 10 1007 BF02533260 PMID 204847 Renooij W Snyder F 1981 Biosynthesis of 1 alkyl 2 acetyl sn glycero 3 phosphocholine platelet activating factor and a hypotensive lipid by cholinephosphotransferase in various rat tissues Biochim Biophys Acta 663 2 545 56 doi 10 1016 0005 2760 81 90182 x PMID 6260215 Portal nbsp Biology This EC 2 7 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Diacylglycerol cholinephosphotransferase amp oldid 1172344538, wikipedia, wiki, book, books, library,

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