Diabetic papillopathy

Diabetic papillopathy (also known as diabetic papillitis) is an ocular complication of diabetes mellitus characterized by optic disc swelling and edema of optic nerve head. The condition may affect both type 1 and type 2 diabetic patients.

Diabetic papillopathy
Other names	Diabetic papillitis
Specialty	Ophthalmology
Causes	Diabetes mellitus
Diagnostic method	Fundus examination

Pathophysiology

Diabetic papillopathy is a self-limiting disease that may affect both type 1 and type 2 diabetic patients. Unilateral or bilateral optic disc edema may occur. The exact etiology, pathogenesis and mechanism of the disc edema is unknown.^[1][2] Theories suggest that the dis edema is due to retinal vascular leakage into and surrounding the optic nerve and disruption of axoplasmic flow resulting from microvascular disease of the optic nerve head.^[2] Edema is seen in and around the optic nerve head also.^[3] Intraretinal hemorrhages and hard exudates may also be seen.^[3]

Diagnosis

Currently accepted criteria for diagnosis of diabetic papillopathy include:^[4]

• Presence of diabetes mellitus (Appr. 70% type 1, 30% type 2)
• Optic disc edema (unilateral in 60% cases)
• Only mild optic nerve dysfunction

Disc edema is diagnosed by fundus examination using ophthalmoscopy or fundus photography. Fundus examination often reveals dilated telangiectatic vessels over the disc also.^[4]

Differential diagnosis

Diabetic papillopathy has many characteristics similar to Non-arteritic anterior ischemic optic neuropathy (NAION).^[5] Diabetic papillopathy is simultaneously bilateral and unlike AION, optic nerve function is not impaired in diabetic papillopathy.^[6] These are the two main clinical features that differentiate diabetic papillopathy from anterior ischemic optic neuropathy.^[6]

Treatment

There is no validated therapy for diabetic papillopathy.^[3][4] The disc swelling usually resolve spontaneously within 4-8 weeks.^[4] Intravitreal corticosteroids or anti–vascular endothelial growth factor therapy may be advised in some cases.^[7]

Epidemiology

Prevalence of diabetic papillopathy in diabetic patients is 1.4%.^[7] It occurs typically before the age of 30 in patients with good vision and mild non‐proliferative diabetic retinopathy.^[2]

History

In 1971, Lubow and Makley first described the disorder as pseudopapilldema in a patient with juvenile diabetes mellitus, which was further elaborated in three case series published in 1980.^[8]

References

1. Ostri, Christoffer; Lund-Andersen, Henrik; Sander, Birgit; Hvidt-Nielsen, Ditte; Larsen, Michael (1 November 2010). "Bilateral Diabetic Papillopathy and Metabolic Control". Ophthalmology. 117 (11): 2214–2217. doi:10.1016/j.ophtha.2010.03.006. ISSN 0161-6420. PMID 20557939.
2. Ahmad, B.; McKnight, J.; Alexander, W. D. (2002). "Diabetic papillopathy". Practical Diabetes International. 19 (1): 24a. doi:10.1002/pdi.281. ISSN 1528-252X.
3. Giuliari, Gian P.; Sadaka, Ama; Chang, Peter Y.; Cortez, Rafael T. (May 2011). "Diabetic papillopathy: current and new treatment options". Current Diabetes Reviews. 7 (3): 171–175. doi:10.2174/157339911795843122. ISSN 1875-6417. PMID 21418004.
4. Myron, Yanoff; Jay S, Duker (2019). Ophthalmology (Fifth ed.). Edinburgh: Elsevier. ISBN 978-0-323-52819-1.
5. "Diabetic Papillopathy in an Asymptomatic Patient". www.aaopt.org.
6. Ramanjit, Sihota; Radhika, Tandon (2015). Parsons' diseases of the eye (Twenty-second ed.). New Delhi, India. p. 369. ISBN 978-81-312-3818-9.{{cite book}}: CS1 maint: location missing publisher (link)
7. Al-Hinai, Ahmed S.; Al-Abri, Mohammed S.; Al-Hajri, Rayah H. (1 September 2011). "Diabetic papillopathy with macular edema treated with intravitreal bevacizumab". Oman Journal of Ophthalmology. 4 (3): 135–138. doi:10.4103/0974-620X.91270. ISSN 0974-620X. PMC 3263167. PMID 22279402.
8. NEMA, HV. NEMA, NITIN (2018). GEMS OF OPHTHALMOLOGY RETINA. JAYPEE Brothers MEDICAL P. ISBN 978-93-5270-402-6. OCLC 1027815824.{{cite book}}: CS1 maint: multiple names: authors list (link)