Derek Blake was, until 2007, the Isobel Laing Post-Doctoral Fellow in Biomedical Sciences, and the Wellcome Trust Senior Fellow in Basic Biomedical Science, Oriel College, Oxford.[1]
He holds a doctorate (D.Phil.) and a Bachelor's (B.Sc. from Liverpool). Blake graduated in Biochemistry and worked on his D.Phil. studies in the Sir William Dunn School of Pathology, Oxford, taking post-doctoral research on the molecular basis of muscular dystrophy.
His research interests lie in the molecular basis of neuronal dysfunction in patients with Duchenne muscular dystrophy and congenital muscular dystrophies (CMD). This led to the discovery of components of the dystrophin protein complex in neurons and identified new genes and pathways that are involved in the pathogenesis of CMD. He was awarded a Wellcome Trust Career Development Fellowship in 1996 and a Wellcome Trust Senior Fellowship in Basic Biomedical Science in 2000. Blake is a member of the American Society for Cell Biology and an editor of the Journal of Nanobiotechnology. Blake's research interests include molecular aspects of neuronal function in muscular dystrophies, glycosyltransferases in neurons and muscle cells, the neuromuscular junction and molecular architecture of the sarcolemma.
Publicationsedit
Blake D.J., Hawkes R., Benson M.A. and Beesley P. (1999) Different dystrophin-like complexes are found in neurons and glia. J. Cell Biol. 147: 645-657.
Blake D.J. and Kröger S. (2000) The molecular neurobiology of muscular dystrophy: Learning lessons from muscle? Trends Neurosci. 23: 92-99.
Newey S.E., Benson, M.A., Ponting C.P., Davies K.E. and Blake D.J. (2000) Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. Curr. Biol. 10: 12951298.
Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R. and Blake D.J. (2001) Dysbindin, a novel coiled-coil containing protein that interacts with the dystrobrevins in muscle and brain. J. Biol. Chem. 276: 24232-24241.
Brockington M., Blake D. J., Prandini P., Brown S. C., Torelli S., Benson M. A., Ponting C. P., Estournet B., Romero N. B., Mercuri E., Voit T., Sewry C. A., Guicheney P. and Muntoni F. (2001) Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin a2 deficiency and abnormal glycosylation of a-dystroglycan. Am J. Hum. Genet. 69: 1198-1209.
Brockington M., Yuva Y., Prandini P., Brown S. C., Torelli S., Benson M. A., Herrmann R., Anderson L. V. B., Bashir R., Burgunder J-M., Fallet S., Romero, N., Guicheney P., Fardeau M., Straub V., Reynolds G., Pollitt C., Sewry C. A., Bushby K., Voit T., Blake D. J. and Muntoni F. (2001) Mutations in the Fukutin Related-Protein gene (FKRP) identifies Limb Girdle Muscular Dystrophy 2I as a milder allelic variant of congenital muscular dystrophy MDC1C. Hum. Mol. Genet. 10: 2851-2859.
Blake D. J, Weir A., Newey S. E. and Davies K. E. (2002) Function and genetics of dystrophin and dystrophin-related proteins in muscle. Phys. Rev. 82: 291-329.
derek, blake, this, biography, living, person, needs, additional, citations, verification, please, help, adding, reliable, sources, contentious, material, about, living, persons, that, unsourced, poorly, sourced, must, removed, immediately, from, article, talk. This biography of a living person needs additional citations for verification Please help by adding reliable sources Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page especially if potentially libelous Find sources Derek Blake news newspapers books scholar JSTOR October 2012 Learn how and when to remove this message Derek Blake was until 2007 the Isobel Laing Post Doctoral Fellow in Biomedical Sciences and the Wellcome Trust Senior Fellow in Basic Biomedical Science Oriel College Oxford 1 He holds a doctorate D Phil and a Bachelor s B Sc from Liverpool Blake graduated in Biochemistry and worked on his D Phil studies in the Sir William Dunn School of Pathology Oxford taking post doctoral research on the molecular basis of muscular dystrophy His research interests lie in the molecular basis of neuronal dysfunction in patients with Duchenne muscular dystrophy and congenital muscular dystrophies CMD This led to the discovery of components of the dystrophin protein complex in neurons and identified new genes and pathways that are involved in the pathogenesis of CMD He was awarded a Wellcome Trust Career Development Fellowship in 1996 and a Wellcome Trust Senior Fellowship in Basic Biomedical Science in 2000 Blake is a member of the American Society for Cell Biology and an editor of the Journal of Nanobiotechnology Blake s research interests include molecular aspects of neuronal function in muscular dystrophies glycosyltransferases in neurons and muscle cells the neuromuscular junction and molecular architecture of the sarcolemma Publications editBlake D J Hawkes R Benson M A and Beesley P 1999 Different dystrophin like complexes are found in neurons and glia J Cell Biol 147 645 657 Blake D J and Kroger S 2000 The molecular neurobiology of muscular dystrophy Learning lessons from muscle Trends Neurosci 23 92 99 Newey S E Benson M A Ponting C P Davies K E and Blake D J 2000 Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex Curr Biol 10 12951298 Benson M A Newey S E Martin Rendon E Hawkes R and Blake D J 2001 Dysbindin a novel coiled coil containing protein that interacts with the dystrobrevins in muscle and brain J Biol Chem 276 24232 24241 Brockington M Blake D J Prandini P Brown S C Torelli S Benson M A Ponting C P Estournet B Romero N B Mercuri E Voit T Sewry C A Guicheney P and Muntoni F 2001 Mutations in the fukutin related protein gene FKRP cause a form of congenital muscular dystrophy with secondary laminin a2 deficiency and abnormal glycosylation of a dystroglycan Am J Hum Genet 69 1198 1209 Brockington M Yuva Y Prandini P Brown S C Torelli S Benson M A Herrmann R Anderson L V B Bashir R Burgunder J M Fallet S Romero N Guicheney P Fardeau M Straub V Reynolds G Pollitt C Sewry C A Bushby K Voit T Blake D J and Muntoni F 2001 Mutations in the Fukutin Related Protein gene FKRP identifies Limb Girdle Muscular Dystrophy 2I as a milder allelic variant of congenital muscular dystrophy MDC1C Hum Mol Genet 10 2851 2859 Blake D J Weir A Newey S E and Davies K E 2002 Function and genetics of dystrophin and dystrophin related proteins in muscle Phys Rev 82 291 329 References edit Oriel College Department of Pharmacology permanent dead link Retrieved from https en wikipedia org w index php title Derek Blake amp oldid 1070312797, wikipedia, wiki, book, books, library,
