Deborah Marie Muoio is the George Barth Geller Distinguished Professor of Cardiovascular Disease at Duke University. She is known for her work on diabetes, obesity, and metabolism.
Muoio grew up in the Buffalo area of New York.[1] She earned her Bachelor’s of Science degree at the University of Florida. After which she originally planned to pursue medical school but instead returned to western New York to University of Buffalo to complete her M.S. degree in nutrition in 1992.[1] She then went on to earn her Ph.D. in nutritional biochemistry at the University of North Carolina, Chapel Hill in 1999.[2] She completed postdoctoral fellowships at East Carolina and Duke Universities working in muscle physiology and metabolic disease.[3] Muoio joined Duke University in 2002, and she was promoted to professor of medicine in 2016. In 2021 she was named the George Barth Geller Distinguished Professor of Cardiovascular Disease at Duke University.[2]
Researchedit
Muoio is known for her research in diabetes, metabolic regulation, mitochondrial energy, muscle physiology and exercise.Muoio's early research examined the lipids in skeletal muscles[4] and metabolic stress responses.[5] She has also worked on how the body's metabolism responds to overeating.[6][7]
Selected publicationsedit
Muoio, Deborah M; Dohn, G Lynis; Fiedorek, Frederick T; Tapscott, Edward B; Coleman, Rosalind A (1 August 1997). "Leptin Directly Alters Lipid Partitioning in Skeletal Muscle". Diabetes. 46 (8): 1360–1363. doi:10.2337/diab.46.8.1360. ISSN 0012-1797. PMID 9231663.
Muoio, Deborah M.; Newgard, Christopher B. (1 June 2006). "Obesity-Related Derangements in Metabolic Regulation". Annual Review of Biochemistry. 75 (1): 367–401. doi:10.1146/annurev.biochem.75.103004.142512. ISSN 0066-4154. PMID 16756496.
Koves, Timothy R.; Ussher, John R.; Noland, Robert C.; Slentz, Dorothy; Mosedale, Merrie; Ilkayeva, Olga; Bain, James; Stevens, Robert; Dyck, Jason R.B.; Newgard, Christopher B.; Lopaschuk, Gary D.; Muoio, Deborah M. (2008). "Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance". Cell Metabolism. 7 (1): 45–56. doi:10.1016/j.cmet.2007.10.013. PMID 18177724.
Muoio, Deborah M.; Newgard, Christopher B. (2008). "Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes". Nature Reviews Molecular Cell Biology. 9 (3): 193–205. doi:10.1038/nrm2327. ISSN 1471-0072. PMID 18200017. S2CID 3335727.
Referencesedit
^ ab"Our alumni: Deborah M. Muoio". publichealth.buffalo.edu. Retrieved 10 October 2023.
^ ab"Deborah Marie Muoio | Scholars@Duke profile". scholars.duke.edu. Retrieved 10 October 2023.
^"Deborah M Muoio Phd | Diabetes Research Centers". diabetescenters.org. Retrieved 10 October 2023.
^Muoio, Deborah M; Dohn, G Lynis; Fiedorek, Frederick T; Tapscott, Edward B; Coleman, Rosalind A (1 August 1997). "Leptin Directly Alters Lipid Partitioning in Skeletal Muscle". Diabetes. 46 (8): 1360–1363. doi:10.2337/diab.46.8.1360. ISSN 0012-1797. PMID 9231663.
^Muoio, Deborah M.; Seefeld, Kimberly; Witters, Lee A.; Coleman, Rosalind A. (15 March 1999). "AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target". Biochemical Journal. 338 (3): 783–791. doi:10.1042/bj3380783. ISSN 0264-6021. PMC1220117. PMID 10051453.
^Muoio, Deborah M. (2014). "Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock". Cell. 159 (6): 1253–1262. doi:10.1016/j.cell.2014.11.034. ISSN 0092-8674. PMC4765362. PMID 25480291.
^Faherty, Sheena. "How Overeating May Contribute to a Metabolic "Traffic Jam"". Scientific American Blog Network. Retrieved 10 October 2023.
deborah, muoio, deborah, marie, muoio, george, barth, geller, distinguished, professor, cardiovascular, disease, duke, university, known, work, diabetes, obesity, metabolism, deborah, marie, muoioacademic, backgroundalma, materuniversity, florida, university, . Deborah Marie Muoio is the George Barth Geller Distinguished Professor of Cardiovascular Disease at Duke University She is known for her work on diabetes obesity and metabolism Deborah Marie MuoioAcademic backgroundAlma materUniversity of Florida University of Buffalo University of North Carolina Chapel Hill Duke UniversityThesisFatty acid partitioning in muscle and liver novel sites of regulation 1999 Contents 1 Education and career 2 Research 3 Selected publications 4 References 5 External linksEducation and career editMuoio grew up in the Buffalo area of New York 1 She earned her Bachelor s of Science degree at the University of Florida After which she originally planned to pursue medical school but instead returned to western New York to University of Buffalo to complete her M S degree in nutrition in 1992 1 She then went on to earn her Ph D in nutritional biochemistry at the University of North Carolina Chapel Hill in 1999 2 She completed postdoctoral fellowships at East Carolina and Duke Universities working in muscle physiology and metabolic disease 3 Muoio joined Duke University in 2002 and she was promoted to professor of medicine in 2016 In 2021 she was named the George Barth Geller Distinguished Professor of Cardiovascular Disease at Duke University 2 Research editMuoio is known for her research in diabetes metabolic regulation mitochondrial energy muscle physiology and exercise Muoio s early research examined the lipids in skeletal muscles 4 and metabolic stress responses 5 She has also worked on how the body s metabolism responds to overeating 6 7 Selected publications editMuoio Deborah M Dohn G Lynis Fiedorek Frederick T Tapscott Edward B Coleman Rosalind A 1 August 1997 Leptin Directly Alters Lipid Partitioning in Skeletal Muscle Diabetes 46 8 1360 1363 doi 10 2337 diab 46 8 1360 ISSN 0012 1797 PMID 9231663 Muoio Deborah M Newgard Christopher B 1 June 2006 Obesity Related Derangements in Metabolic Regulation Annual Review of Biochemistry 75 1 367 401 doi 10 1146 annurev biochem 75 103004 142512 ISSN 0066 4154 PMID 16756496 Koves Timothy R Ussher John R Noland Robert C Slentz Dorothy Mosedale Merrie Ilkayeva Olga Bain James Stevens Robert Dyck Jason R B Newgard Christopher B Lopaschuk Gary D Muoio Deborah M 2008 Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance Cell Metabolism 7 1 45 56 doi 10 1016 j cmet 2007 10 013 PMID 18177724 Muoio Deborah M Newgard Christopher B 2008 Molecular and metabolic mechanisms of insulin resistance and b cell failure in type 2 diabetes Nature Reviews Molecular Cell Biology 9 3 193 205 doi 10 1038 nrm2327 ISSN 1471 0072 PMID 18200017 S2CID 3335727 References edit a b Our alumni Deborah M Muoio publichealth buffalo edu Retrieved 10 October 2023 a b Deborah Marie Muoio Scholars Duke profile scholars duke edu Retrieved 10 October 2023 Deborah M Muoio Phd Diabetes Research Centers diabetescenters org Retrieved 10 October 2023 Muoio Deborah M Dohn G Lynis Fiedorek Frederick T Tapscott Edward B Coleman Rosalind A 1 August 1997 Leptin Directly Alters Lipid Partitioning in Skeletal Muscle Diabetes 46 8 1360 1363 doi 10 2337 diab 46 8 1360 ISSN 0012 1797 PMID 9231663 Muoio Deborah M Seefeld Kimberly Witters Lee A Coleman Rosalind A 15 March 1999 AMP activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle evidence that sn glycerol 3 phosphate acyltransferase is a novel target Biochemical Journal 338 3 783 791 doi 10 1042 bj3380783 ISSN 0264 6021 PMC 1220117 PMID 10051453 Muoio Deborah M 2014 Metabolic Inflexibility When Mitochondrial Indecision Leads to Metabolic Gridlock Cell 159 6 1253 1262 doi 10 1016 j cell 2014 11 034 ISSN 0092 8674 PMC 4765362 PMID 25480291 Faherty Sheena How Overeating May Contribute to a Metabolic Traffic Jam Scientific American Blog Network Retrieved 10 October 2023 External links editDeborah Muoio publications indexed by Google Scholar Retrieved from https en wikipedia org w index php title Deborah Muoio amp oldid 1195408724, wikipedia, wiki, book, books, library,
