Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.[4]
^Xin A (Jan 2014). "Soluble fusion expression, characterization and localization of human β-defensin 6..." Mol Med Rep. 9 (1): 149–55. doi:10.3892/mmr.2013.1768. PMID 24189797.
Further readingedit
Yamaguchi Y, Nagase T, Makita R, et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice". J. Immunol. 169 (5): 2516–23. doi:10.4049/jimmunol.169.5.2516. PMID 12193721.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. CiteSeerX10.1.1.108.7808. doi:10.1165/rcmb.2002-0205OC. PMID 12600824.
Semple CA, Rolfe M, Dorin JR (2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC156587. PMID 12734011.
Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster". Am. J. Hum. Genet. 73 (3): 591–600. doi:10.1086/378157. PMC1180683. PMID 12916016.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Taudien S, Galgoczy P, Huse K, et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence". BMC Genomics. 5 (1): 92. doi:10.1186/1471-2164-5-92. PMC544879. PMID 15588320.
Boniotto M, Ventura M, Eskdale J, et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID 15727258.
Patil AA, Cai Y, Sang Y, et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract". Physiol. Genomics. 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865. S2CID 22355626.
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defb106a, beta, defensin, protein, that, humans, encoded, gene, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes2lwlidentifiersaliases, defb, defb106, defensin, beta, 106aexternal, idshomologene, 134659, genecards, gene, location, human, c. Beta defensin 106 is a protein that in humans is encoded by the DEFB106A gene 3 4 DEFB106AAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes2LWLIdentifiersAliasesDEFB106A BD 6 DEFB 6 DEFB106 defensin beta 106AExternal IDsHomoloGene 134659 GeneCards DEFB106AGene location Human Chr Chromosome 8 human 1 Band8p23 1Start7 825 139 bp 1 End7 829 053 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inlivercellmonocytebloodhuman musculoskeletal systemright lobe of livermuscle of legfundusgastrocnemius musclebody of pancreasn aMore reference expression dataBioGPSn aGene ontologyMolecular functionlipopolysaccharide binding heparin binding protein binding CCR2 chemokine receptor bindingCellular componentextracellular region nucleus cell surface extrinsic component of membrane microvesicle membraneBiological processdefense response defense response to bacterium innate immune responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez245909n aEnsemblENSG00000186579ENSG00000285617n aUniProtQ8N104n aRefSeq mRNA NM 152251n aRefSeq protein NP 689464n aLocation UCSC Chr 8 7 83 7 83 Mbn aPubMed search 2 n aWikidataView Edit Human Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils Defensins are short processed peptide molecules that are classified by structure into three groups alpha defensins beta defensins and theta defensins All beta defensin genes are densely clustered in four to five syntenic chromosomal regions Chromosome 8p23 contains at least two copies of the duplicated beta defensin cluster This duplication results in two identical copies of defensin beta 106 DEFB106A and DEFB106B in head to head orientation This gene DEFB106A represents the more centromeric copy 4 Function editThe purified DEFB106 showed antimicrobial activity against Escherichia coli Candida albicans and Staphylococcus aureus 5 References edit a b c ENSG00000285617 GRCh38 Ensembl release 89 ENSG00000186579 ENSG00000285617 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Schutte BC Mitros JP Bartlett JA Walters JD Jia HP Welsh MJ Casavant TL McCray PB Jr Feb 2002 Discovery of five conserved beta defensin gene clusters using a computational search strategy Proc Natl Acad Sci U S A 99 4 2129 33 Bibcode 2002PNAS 99 2129S doi 10 1073 pnas 042692699 PMC 122330 PMID 11854508 a b Entrez Gene DEFB106A defensin beta 106A Xin A Jan 2014 Soluble fusion expression characterization and localization of human b defensin 6 Mol Med Rep 9 1 149 55 doi 10 3892 mmr 2013 1768 PMID 24189797 Further reading editYamaguchi Y Nagase T Makita R et al 2002 Identification of multiple novel epididymis specific beta defensin isoforms in humans and mice J Immunol 169 5 2516 23 doi 10 4049 jimmunol 169 5 2516 PMID 12193721 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Kao CY Chen Y Zhao YH Wu R 2003 ORFeome based search of airway epithelial cell specific novel human beta defensin genes Am J Respir Cell Mol Biol 29 1 71 80 CiteSeerX 10 1 1 108 7808 doi 10 1165 rcmb 2002 0205OC PMID 12600824 Semple CA Rolfe M Dorin JR 2003 Duplication and selection in the evolution of primate beta defensin genes Genome Biol 4 5 R31 doi 10 1186 gb 2003 4 5 r31 PMC 156587 PMID 12734011 Hollox EJ Armour JA Barber JC 2003 Extensive normal copy number variation of a beta defensin antimicrobial gene cluster Am J Hum Genet 73 3 591 600 doi 10 1086 378157 PMC 1180683 PMID 12916016 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Taudien S Galgoczy P Huse K et al 2006 Polymorphic segmental duplications at 8p23 1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence BMC Genomics 5 1 92 doi 10 1186 1471 2164 5 92 PMC 544879 PMID 15588320 Boniotto M Ventura M Eskdale J et al 2005 Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22 23 and implications for the analysis of SNP allele distribution Genet Test 8 3 325 7 doi 10 1089 gte 2004 8 325 PMID 15727258 Patil AA Cai Y Sang Y et al 2006 Cross species analysis of the mammalian beta defensin gene family presence of syntenic gene clusters and preferential expression in the male reproductive tract Physiol Genomics 23 1 5 17 doi 10 1152 physiolgenomics 00104 2005 PMID 16033865 S2CID 22355626 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DEFB106A amp oldid 1214264148, wikipedia, wiki, book, books, library,
