For breast pathology, also in distinguishing usual ductal hyperplasia (UDH) and papillary lesions (having a mosaic-like pattern) from ductal carcinoma in situ, which is usually negative.[1]Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive) or papillary carcinoma (Cyclin D1 > 37.00%, CK 5/6 negative).[2]
Immunohistochemistry with cytokeratin 5/6 antibodies in usual ductal hyperplasia, showing a mosaic pattern, predominantly in the central zone.
Until recently the diagnostic method predominantly depended on identifying antibodies' responses that are positive for adenocarcinoma and negative for mesothelioma.[3]
Cytokeratin 5/6 (CK5/6) is a biomarker that has emerged as a valuable tool in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma. In a study comparing its effectiveness with other markers, CK5/6 showed high sensitivity, staining positively in 92% of epithelioid pleural mesothelioma cases. In contrast, only 14% of metastatic adenocarcinomas were positive for CK5/6. Cytokeratin 5/6 also strains reactive mesothelium, which limits its specificity. Overall, CK5/6, along with other markers like calretinin and thrombomodulin, demonstrates high sensitivity for epithelioid mesothelioma, making it a valuable tool in diagnostic pathology.[4]
Referencesedit
^ abcdRobert Terlević, Semir Vranić. "Cytokeratin 5/6". Topic Completed: 3 June 2019. Revised: 8 December 2019
^ abWang, Yu; Zhu, Jin-fu; Liu, Ying-ying; Han, Gui-ping (2013). "An analysis of Cyclin D1, Cytokeratin 5/6 and Cytokeratin 8/18 expression in breast papillomas and papillary carcinomas". Diagnostic Pathology. 8 (1). doi:10.1186/1746-1596-8-8. ISSN 1746-1596. PMC3571902.
^Cury, P M; Butcher, D N; Fisher, C; Corrin, B; Nicholson, A G (2000-02-01). "Value of the Mesothelium-Associated Antibodies Thrombomodulin, Cytokeratin 5/6, Calretinin, and CD44H in Distinguishing Epithelioid Pleural Mesothelioma from Adenocarcinoma Metastatic to the Pleura". Modern Pathology. 13 (2): 107–112. doi:10.1038/modpathol.3880018. ISSN 0893-3952.
^Clover, J.; Oates, J.; Edwards, C. (2003-11-14). "Anti‐cytokeratin 5/6: a positive marker for epithelioid mesothelioma". Histopathology. 31 (2): 140–143. doi:10.1046/j.1365-2559.1997.2150833.x. ISSN 0309-0167.
External linksedit
Recombinant Antibodies
This biochemistry article is a stub. You can help Wikipedia by expanding it.
cytokeratin, antibodies, antibodies, that, target, both, cytokeratin, cytokeratin, these, used, immunohistochemistry, often, called, staining, including, following, applications, identifying, basal, cells, myoepithelial, cells, breast, prostate, breast, pathol. Cytokeratin 5 6 antibodies are antibodies that target both cytokeratin 5 and cytokeratin 6 1 These are used in immunohistochemistry often called CK 5 6 staining 2 including the following applications Identifying basal cells or myoepithelial cells in the breast and prostate 1 For breast pathology also in distinguishing usual ductal hyperplasia UDH and papillary lesions having a mosaic like pattern from ductal carcinoma in situ which is usually negative 1 Cyclin D1 and CK5 6 staining could be used in concert to distinguish between the diagnosis of papilloma Cyclin D1 lt 4 20 CK 5 6 positive or papillary carcinoma Cyclin D1 gt 37 00 CK 5 6 negative 2 In the lung distinguishing epithelioid mesothelioma CK5 6 positive in 83 from lung adenocarcinoma CK5 6 negative in 85 1 Immunohistochemistry with cytokeratin 5 6 antibodies in usual ductal hyperplasia showing a mosaic pattern predominantly in the central zone Until recently the diagnostic method predominantly depended on identifying antibodies responses that are positive for adenocarcinoma and negative for mesothelioma 3 Cytokeratin 5 6 CK5 6 is a biomarker that has emerged as a valuable tool in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma In a study comparing its effectiveness with other markers CK5 6 showed high sensitivity staining positively in 92 of epithelioid pleural mesothelioma cases In contrast only 14 of metastatic adenocarcinomas were positive for CK5 6 Cytokeratin 5 6 also strains reactive mesothelium which limits its specificity Overall CK5 6 along with other markers like calretinin and thrombomodulin demonstrates high sensitivity for epithelioid mesothelioma making it a valuable tool in diagnostic pathology 4 References edit a b c d Robert Terlevic Semir Vranic Cytokeratin 5 6 Topic Completed 3 June 2019 Revised 8 December 2019 a b Wang Yu Zhu Jin fu Liu Ying ying Han Gui ping 2013 An analysis of Cyclin D1 Cytokeratin 5 6 and Cytokeratin 8 18 expression in breast papillomas and papillary carcinomas Diagnostic Pathology 8 1 doi 10 1186 1746 1596 8 8 ISSN 1746 1596 PMC 3571902 Cury P M Butcher D N Fisher C Corrin B Nicholson A G 2000 02 01 Value of the Mesothelium Associated Antibodies Thrombomodulin Cytokeratin 5 6 Calretinin and CD44H in Distinguishing Epithelioid Pleural Mesothelioma from Adenocarcinoma Metastatic to the Pleura Modern Pathology 13 2 107 112 doi 10 1038 modpathol 3880018 ISSN 0893 3952 Clover J Oates J Edwards C 2003 11 14 Anti cytokeratin 5 6 a positive marker for epithelioid mesothelioma Histopathology 31 2 140 143 doi 10 1046 j 1365 2559 1997 2150833 x ISSN 0309 0167 External links editRecombinant Antibodies nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Cytokeratin 5 6 antibodies amp oldid 1222475656, wikipedia, wiki, book, books, library,
