Cucumisin

Cucumisin (EC 3.4.21.25, euphorbain, solanain, hurain, tabernamontanain) is an enzyme.^{[1][2][3][4][5][6][7]} This enzyme catalyzes hydrolysis of a wide range of proteins. It has been identified as an allergen in humans.^[8]

Cucumisin
Identifiers
EC no.	3.4.21.25
CAS no.	82062-89-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is isolated from the sarcocarp of the musk melon (Cucumis melo).

References

1. Greenberg DM, Winnick T (1940). "Plant proteases. I. Activation-inhibition reactions". J. Biol. Chem. 135: 761–773.
2. Jaffé WG (1943). "Hurain, a new plant protease from Hura crepitans". J. Biol. Chem. 149: 1–7.
3. Jaffé WG (1943). "A new vegetable proteolytic enzyme of the papain class". Rev. Brasil Biol. 3: 149–157.
4. Kaneda M, Tominaga N (December 1975). "Isolation and characterization of a proteinase from the sarcocarp of melon fruit". Journal of Biochemistry. 78 (6): 1287–96. PMID 5423.
5. Kaneda M, Ohmine H, Yonezawa H, Tominaga N (March 1984). "Amino acid sequence around the reactive serine of cucumisin from melon fruit". Journal of Biochemistry. 95 (3): 825–9. PMID 6427203.
6. Lynn KR, Clevette-Radford NA (1985). "Two proteases from the latex of Elaeophorbia drupifera". Phytochemistry. 24: 2843–2845. doi:10.1016/0031-9422(85)80011-x.
7. Kaneda N, Minematsu Y, Powers JC, Tominaga N (1986). "Specificity of cucumisin in hydrolysis of peptide thiobenzyl esters". Agric. Biol. Chem. 50: 1075–1076. doi:10.1271/bbb1961.50.1075.
8. Sankian M, Talebi F, Moghadam M, Vahedi F, Jabbari Azad F, Varasteh A (2011). "Molecular Cloning and Expression of Cucumisin (Cuc m 1), a Subtilisin-like Protease of Cucumis melo in Escherichia coli". Allergology International. 60 (1): 61–67. doi:10.2332/allergolint.10-OA-0195.

External links

• Cucumisin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)