This gene produces a long non-codingRNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types.[4] This transcript may regulate long range chromosomal interactions, including at the Myc oncoprotein locus.[5] This RNA may also function as a molecular sponge for microRNAs.[6]
Referencesedit
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G (2013). "Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma". J. Cancer Res. Clin. Oncol. 139 (3): 437–45. doi:10.1007/s00432-012-1324-x. PMID 23143645. S2CID 667876.
Alaiyan B, Ilyayev N, Stojadinovic A, Izadjoo M, Roistacher M, Pavlov V, Tzivin V, Halle D, Pan H, Trink B, Gure AO, Nissan A (2013). "Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence". BMC Cancer. 13: 196. doi:10.1186/1471-2407-13-196. PMC3639026. PMID 23594791.
Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO, Wu Z, Zhang S, Wang HB, Ge J, Lu X, Yang L, Chen LL (2014). "Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus". Cell Res. 24 (5): 513–31. doi:10.1038/cr.2014.35. PMC4011346. PMID 24662484.
Luo J, Tang L, Zhang J, Ni J, Zhang HP, Zhang L, Xu JF, Zheng D (2014). "Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer". Tumour Biol. 35 (11): 11541–9. doi:10.1007/s13277-014-2442-7. PMID 25129441. S2CID 17249302.
Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W, Quan ZW (2015). "Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p". Cell Death Dis. 6: e1583. doi:10.1038/cddis.2014.541. PMC4669740. PMID 25569100.
Zhang Y, Ma M, Liu W, Ding W, Yu H (2014). "Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer". Int J Clin Exp Pathol. 7 (12): 8471–9. PMC4314006. PMID 25674211.
Cabanski CR, White NM, Dang HX, Silva-Fisher JM, Rauck CE, Cicka D, Maher CA (2015). "Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function". RNA Biol. 12 (6): 628–42. doi:10.1080/15476286.2015.1038012. PMC4615893. PMID 25864709.
Deng L, Yang SB, Xu FF, Zhang JH (2015). "Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge". J. Exp. Clin. Cancer Res. 34: 18. doi:10.1186/s13046-015-0136-7. PMC4339002. PMID 25884472.
Zhu H, Zhou X, Chang H, Li H, Liu F, Ma C, Lu J (2015). "CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion". Int J Clin Exp Pathol. 8 (5): 5427–34. PMC4503117. PMID 26191246.
This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.
colon, cancer, associated, transcript, long, coding, that, humans, encoded, ccat1, gene, ccat1identifiersaliasesccat1, carlo, onco, lncrna, colon, cancer, associated, transcript, protein, coding, carlo5, colon, cancer, associated, transcript, 1external, idsomi. Colon cancer associated transcript 1 is a long non coding RNA that in humans is encoded by the CCAT1 gene 2 3 CCAT1IdentifiersAliasesCCAT1 CARLo 5 onco lncRNA 40 colon cancer associated transcript 1 non protein coding CARLO5 colon cancer associated transcript 1External IDsOMIM 617705 GeneCards CCAT1OrthologsSpeciesHumanMouseEntrez100507056n aEnsembln an aUniProtnan aRefSeq mRNA n an aRefSeq protein n an aLocation UCSC n an aPubMed search 1 n aWikidataView Edit HumanThis gene produces a long non coding RNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types 4 This transcript may regulate long range chromosomal interactions including at the Myc oncoprotein locus 5 This RNA may also function as a molecular sponge for microRNAs 6 References edit Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene Colon cancer associated transcript 1 non protein coding Retrieved 2017 03 16 CCAT2 colon cancer associated transcript 2 Homo sapiens human Gene NCBI www ncbi nlm nih gov Retrieved 2020 06 13 CCAT1 Gene GeneCards CCAT1 RNA Gene www genecards org Retrieved 2020 06 29 CCAT1 colon cancer associated transcript 1 Homo sapiens human Gene NCBI www ncbi nlm nih gov Retrieved 2020 06 29 CCAT1 Gene GeneCards CCAT1 RNA Gene www genecards org Retrieved 2020 06 29 Further reading editYang F Xue X Bi J Zheng L Zhi K Gu Y Fang G 2013 Long noncoding RNA CCAT1 which could be activated by c Myc promotes the progression of gastric carcinoma J Cancer Res Clin Oncol 139 3 437 45 doi 10 1007 s00432 012 1324 x PMID 23143645 S2CID 667876 Alaiyan B Ilyayev N Stojadinovic A Izadjoo M Roistacher M Pavlov V Tzivin V Halle D Pan H Trink B Gure AO Nissan A 2013 Differential expression of colon cancer associated transcript1 CCAT1 along the colonic adenoma carcinoma sequence BMC Cancer 13 196 doi 10 1186 1471 2407 13 196 PMC 3639026 PMID 23594791 Xiang JF Yin QF Chen T Zhang Y Zhang XO Wu Z Zhang S Wang HB Ge J Lu X Yang L Chen LL 2014 Human colorectal cancer specific CCAT1 L lncRNA regulates long range chromatin interactions at the MYC locus Cell Res 24 5 513 31 doi 10 1038 cr 2014 35 PMC 4011346 PMID 24662484 Luo J Tang L Zhang J Ni J Zhang HP Zhang L Xu JF Zheng D 2014 Long non coding RNA CARLo 5 is a negative prognostic factor and exhibits tumor pro oncogenic activity in non small cell lung cancer Tumour Biol 35 11 11541 9 doi 10 1007 s13277 014 2442 7 PMID 25129441 S2CID 17249302 Ma MZ Chu BF Zhang Y Weng MZ Qin YY Gong W Quan ZW 2015 Long non coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA 218 5p Cell Death Dis 6 e1583 doi 10 1038 cddis 2014 541 PMC 4669740 PMID 25569100 Zhang Y Ma M Liu W Ding W Yu H 2014 Enhanced expression of long noncoding RNA CARLo 5 is associated with the development of gastric cancer Int J Clin Exp Pathol 7 12 8471 9 PMC 4314006 PMID 25674211 Cabanski CR White NM Dang HX Silva Fisher JM Rauck CE Cicka D Maher CA 2015 Pan cancer transcriptome analysis reveals long noncoding RNAs with conserved function RNA Biol 12 6 628 42 doi 10 1080 15476286 2015 1038012 PMC 4615893 PMID 25864709 Deng L Yang SB Xu FF Zhang JH 2015 Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let 7 sponge J Exp Clin Cancer Res 34 18 doi 10 1186 s13046 015 0136 7 PMC 4339002 PMID 25884472 Zhu H Zhou X Chang H Li H Liu F Ma C Lu J 2015 CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion Int J Clin Exp Pathol 8 5 5427 34 PMC 4503117 PMID 26191246 nbsp This article on a gene on human chromosome 8 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Colon cancer associated transcript 1 amp oldid 1081687267, wikipedia, wiki, book, books, library,
