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Colin L. Masters

October 20, 2023

Colin Louis Masters MD FAA AO (born 5 Feb 1947 in Perth, Western Australia) is an Australian neuropathologist who researches Alzheimer's disease and other neurodegenerative disorders. He is laureate professor of pathology at the University of Melbourne.[1][2]

Colin L. Masters
Born (1947-02-05) February 5, 1947 (age 76)
Perth, Western Australia
NationalityAustralian
EducationUniversity of Western Australia (MB BS 1970, MD 1977)
Known forneurodegenerative diseases
AwardsPotamkin Prize (1990)
King Faisal International Prize in Medicine (1997)
Scientific career
Fieldsneuropathology
InstitutionsNINDS (1977-1981)
Heidelberg University (1981-2)
University of Western Australia (1981-9)
University of Melbourne (1989-)

Career Edit

Masters studied medicine at the University of Western Australia.[3] He opted for an extra year of pre-medical studies in 1967, which he spent doing neuropathology research,[4] and graduated M.B. B.S. in 1970. He completed his M.D. in medical neuropathology in 1977 after research fellowships at the University of Western Australia and Massachusetts General Hospital. After positions as visiting scientist at the National Institute of Neurological Disorders and Stroke and Humboldt fellow at Heidelberg University, he returned to Western Australia and Royal Perth Hospital in 1981 as a clinician-scientist. In 1989 he relocated to the University of Melbourne where he spent the rest of his career as consultant pathologist and professor of pathology, becoming laureate professor in 2002 and serving for six years as associate dean of research at the medical and dental school.[3]

Scientific achievements Edit

Masters and his erstwhile colleague from Heidelberg Konrad Beyreuther were the first to characterize the amyloid protein that forms the cerebral plaques observed in Alzheimer's disease (AD) and Down's Syndrome (DS, also known as trisomy 21).[5] Known as amyloid beta (Aβ), this peptide is derived from amyloid precursor protein (APP), which was subsequently mapped to the region of chromosome 21 that is altered in DS.[6] The notion that Aβ causes AD, called the amyloid hypothesis, gained force from genetic studies that traced familial forms of the disease to variations in the APP gene.[7] Masters became a prominent proponent of the amyloid hypothesis, developing strategies for anti-Alzheimer's treatments that suppress the beta secretase and gamma secretase enzymes that cleave APP to form Aβ, or modify the interactions between metal ions and Aβ that are important for its toxic effects. Despite two decades of intensive research, however, these approaches have not yielded useful drugs.[8]

Awards Edit

Masters and Beyreuther both received Max Planck Research Awards [de] in 1991.[9] They also jointly won the 1990 Potamkin Prize[10] and the 1995 Zülch Award [de].[11] In 1997 they were awarded the King Faisal International Prize in Medicine, together with James F. Gusella, for contributions to the understanding of neurodegenerative diseases.[12] Masters won the Florey Medal in 2002.[13] In 2006, he was awarded the Grand Hamdan International Award for Medical Sciences in the field of Molecular and Cellular Pathology of Neurological Disorders.[14] He also received a Lifetime Achievement Award in Alzheimer's Disease Research from the Alzheimer's Association.[15] He is a fellow of the Australian Academy of Science, the Royal College of Pathologists in England, and the Royal College of Pathologists, Australia.[3] He was elected Fellow of the Australian Academy of Health and Medical Sciences (FAHMS) in 2015.[16] He is Honorary Doctor of Letters of the University of Western Australia (2008).[1] He was appointed Officer of the Order of Australia on Australia Day, 2017.[17]

References Edit

  1. ^ a b "Prof Colin Masters". The University of Melbourne. Retrieved 29 September 2018.
  2. ^ "Masters, Colin L. (1947-) - People and organisations". Trove. 11 December 1947. Retrieved 30 September 2018.
  3. ^ a b c Walker, Rosanne (26 March 2007). "Biographical entry - Encyclopedia of Australian Science". Masters, Colin Louis. Retrieved 30 September 2018.
  4. ^ "Colin Masters Interview - Special Topic of Alzheimer's Disease". ScienceWatch.com. 25 May 2011. Retrieved 1 October 2018.
  5. ^ Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985). "Amyloid plaque core protein in Alzheimer disease and Down syndrome". Proc Natl Acad Sci U S A. 82 (12): 4245–9. doi:10.1073/pnas.82.12.4245. PMC 397973. PMID 3159021.
  6. ^ Tanzi RE, Bertram L (2005). "Twenty Years of the Alzheimer's Disease Amyloid Hypothesis: A Genetic Perspective". Cell. Elsevier BV. 120 (4): 545–555. doi:10.1016/j.cell.2005.02.008. ISSN 0092-8674. PMID 15734686.
  7. ^ Goate A; et al. (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. Springer Nature. 349 (6311): 704–706. doi:10.1038/349704a0. ISSN 0028-0836. PMID 1671712. S2CID 4336069.
  8. ^ Makin S (2018). "The amyloid hypothesis on trial". Nature. Springer Nature. 559 (7715): S4–S7. doi:10.1038/d41586-018-05719-4. ISSN 0028-0836. PMID 30046080.
  9. ^ "Max-Planck-Forschungspreis" [Max Planck Research Award]. Max-Planck-Gesellschaft (in German). from the original on 25 September 2009. Retrieved 30 September 2018.
  10. ^ "Awards History". American Academy of Neurology. Retrieved 30 September 2018.
  11. ^ "Zülch Prize". Max-Planck-Gesellschaft. 26 September 2018. Retrieved 30 September 2018.
  12. ^ "Professor Colin L. Masters". King Faisal Prize. 10 October 2012. Retrieved 13 August 2018.
  13. ^ . Australian Institute of Policy and Science. Archived from the original on 30 September 2018. Retrieved 30 September 2018.
  14. ^ "Prof. Colin Masters". Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences. Retrieved 30 September 2018.
  15. ^ Strobel, Gabrielle (13 September 2006). "Madrid: Pooled Antibody Cocktail, New Metal Quencher". Retrieved 30 September 2018.
  16. ^ "Fellowship of the Australian Academy of Health & Medical Sciences - October 2015" (PDF). Australian Academy of Health & Medical Sciences. Retrieved 12 October 2018.
  17. ^ "2017 Australia Day honours list: Julia Gillard appointed an AC". The Sydney Morning Herald. 25 January 2017. Retrieved 30 September 2018.

October 20, 2023
colin, masters, colin, louis, masters, born, 1947, perth, western, australia, australian, neuropathologist, researches, alzheimer, disease, other, neurodegenerative, disorders, laureate, professor, pathology, university, melbourne, born, 1947, february, 1947, . Colin Louis Masters MD FAA AO born 5 Feb 1947 in Perth Western Australia is an Australian neuropathologist who researches Alzheimer s disease and other neurodegenerative disorders He is laureate professor of pathology at the University of Melbourne 1 2 Colin L MastersBorn 1947 02 05 February 5 1947 age 76 Perth Western AustraliaNationalityAustralianEducationUniversity of Western Australia MB BS 1970 MD 1977 Known forneurodegenerative diseasesAwardsPotamkin Prize 1990 King Faisal International Prize in Medicine 1997 Scientific careerFieldsneuropathologyInstitutionsNINDS 1977 1981 Heidelberg University 1981 2 University of Western Australia 1981 9 University of Melbourne 1989 Contents 1 Career 2 Scientific achievements 3 Awards 4 ReferencesCareer EditMasters studied medicine at the University of Western Australia 3 He opted for an extra year of pre medical studies in 1967 which he spent doing neuropathology research 4 and graduated M B B S in 1970 He completed his M D in medical neuropathology in 1977 after research fellowships at the University of Western Australia and Massachusetts General Hospital After positions as visiting scientist at the National Institute of Neurological Disorders and Stroke and Humboldt fellow at Heidelberg University he returned to Western Australia and Royal Perth Hospital in 1981 as a clinician scientist In 1989 he relocated to the University of Melbourne where he spent the rest of his career as consultant pathologist and professor of pathology becoming laureate professor in 2002 and serving for six years as associate dean of research at the medical and dental school 3 Scientific achievements EditMasters and his erstwhile colleague from Heidelberg Konrad Beyreuther were the first to characterize the amyloid protein that forms the cerebral plaques observed in Alzheimer s disease AD and Down s Syndrome DS also known as trisomy 21 5 Known as amyloid beta Ab this peptide is derived from amyloid precursor protein APP which was subsequently mapped to the region of chromosome 21 that is altered in DS 6 The notion that Ab causes AD called the amyloid hypothesis gained force from genetic studies that traced familial forms of the disease to variations in the APP gene 7 Masters became a prominent proponent of the amyloid hypothesis developing strategies for anti Alzheimer s treatments that suppress the beta secretase and gamma secretase enzymes that cleave APP to form Ab or modify the interactions between metal ions and Ab that are important for its toxic effects Despite two decades of intensive research however these approaches have not yielded useful drugs 8 Awards EditMasters and Beyreuther both received Max Planck Research Awards de in 1991 9 They also jointly won the 1990 Potamkin Prize 10 and the 1995 Zulch Award de 11 In 1997 they were awarded the King Faisal International Prize in Medicine together with James F Gusella for contributions to the understanding of neurodegenerative diseases 12 Masters won the Florey Medal in 2002 13 In 2006 he was awarded the Grand Hamdan International Award for Medical Sciences in the field of Molecular and Cellular Pathology of Neurological Disorders 14 He also received a Lifetime Achievement Award in Alzheimer s Disease Research from the Alzheimer s Association 15 He is a fellow of the Australian Academy of Science the Royal College of Pathologists in England and the Royal College of Pathologists Australia 3 He was elected Fellow of the Australian Academy of Health and Medical Sciences FAHMS in 2015 16 He is Honorary Doctor of Letters of the University of Western Australia 2008 1 He was appointed Officer of the Order of Australia on Australia Day 2017 17 References Edit a b Prof Colin Masters The University of Melbourne Retrieved 29 September 2018 Masters Colin L 1947 People and organisations Trove 11 December 1947 Retrieved 30 September 2018 a b c Walker Rosanne 26 March 2007 Biographical entry Encyclopedia of Australian Science Masters Colin Louis Retrieved 30 September 2018 Colin Masters Interview Special Topic of Alzheimer s Disease ScienceWatch com 25 May 2011 Retrieved 1 October 2018 Masters CL Simms G Weinman NA Multhaup G McDonald BL Beyreuther K 1985 Amyloid plaque core protein in Alzheimer disease and Down syndrome Proc Natl Acad Sci U S A 82 12 4245 9 doi 10 1073 pnas 82 12 4245 PMC 397973 PMID 3159021 Tanzi RE Bertram L 2005 Twenty Years of the Alzheimer s Disease Amyloid Hypothesis A Genetic Perspective Cell Elsevier BV 120 4 545 555 doi 10 1016 j cell 2005 02 008 ISSN 0092 8674 PMID 15734686 Goate A et al 1991 Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer s disease Nature Springer Nature 349 6311 704 706 doi 10 1038 349704a0 ISSN 0028 0836 PMID 1671712 S2CID 4336069 Makin S 2018 The amyloid hypothesis on trial Nature Springer Nature 559 7715 S4 S7 doi 10 1038 d41586 018 05719 4 ISSN 0028 0836 PMID 30046080 Max Planck Forschungspreis Max Planck Research Award Max Planck Gesellschaft in German Archived from the original on 25 September 2009 Retrieved 30 September 2018 Awards History American Academy of Neurology Retrieved 30 September 2018 Zulch Prize Max Planck Gesellschaft 26 September 2018 Retrieved 30 September 2018 Professor Colin L Masters King Faisal Prize 10 October 2012 Retrieved 13 August 2018 CSL Florey Medal 2002 Professor Colin Masters Australian Institute of Policy and Science Archived from the original on 30 September 2018 Retrieved 30 September 2018 Prof Colin Masters Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences Retrieved 30 September 2018 Strobel Gabrielle 13 September 2006 Madrid Pooled Antibody Cocktail New Metal Quencher Retrieved 30 September 2018 Fellowship of the Australian Academy of Health amp Medical Sciences October 2015 PDF Australian Academy of Health amp Medical Sciences Retrieved 12 October 2018 2017 Australia Day honours list Julia Gillard appointed an AC The Sydney Morning Herald 25 January 2017 Retrieved 30 September 2018 Retrieved from https en wikipedia org w index php title Colin L Masters amp oldid 1160418995, wikipedia, wiki, book, books, library,

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