Cobalt-precorrin-5B (C1)-methyltransferase

Cobalt-precorrin-5B (C¹)-methyltransferase (EC 2.1.1.195), cobalt-precorrin-6A synthase, CbiD (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:cobalt-precorrin-5B (C¹)-methyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

Cobalt-precorrin-5B (C^1)-methyltransferase
Identifiers
EC no.	2.1.1.195
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

cobalt-precorrin-5B + S-adenosyl-L-methionine ${\displaystyle \rightleftharpoons }$ cobalt-precorrin-6A + S-adenosyl-L-homocysteine

This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic pathway^[3] of adenosylcobalamin biosynthesis in bacteria such as Salmonella typhimurium, Bacillus megaterium, and Propionibacterium freudenreichii subsp. shermanii.

See also

• Cobalamin biosynthesis

References

1. Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ (December 2000). "The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway". The Journal of Biological Chemistry. 275 (51): 40316–23. doi:10.1074/jbc.M007146200. PMID 11007789.
2. Roessner CA, Williams HJ, Scott AI (April 2005). "Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin". The Journal of Biological Chemistry. 280 (17): 16748–53. doi:10.1074/jbc.M501805200. PMID 15741157.
3. R. Caspi (2013-09-25). "Pathway: adenosylcobalamin biosynthesis I (anaerobic)". MetaCyc Metabolic Pathway Database. Retrieved 2020-04-24.

External links

• Cobalt-precorrin-5B+(C1)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)