In a nosological sense, the term phenotype can be used in clinical medicine for speaking about the presentation of a disease.[1] The complementary concept in this regard is endotype, which refers to the pathogenesis of the disease ignoring its presentation.[2]
In this context, a phenotype would be any observable characteristic or trait of a disease, such as morphology, development, biochemical or physiological properties, or behavior, without any implication of a mechanism. A clinical phenotype would be the presentation of a disease in a given individual.[citation needed]
Some organizations have their own specialised meaning. For example, the term 'phenotype' in the field of chronic obstructive pulmonary disease (COPD) means "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes",[3] but nearly all specialities use this meaning in some way, like in asthma research.[4]
Etymologyedit
The word phenotype comes from Greek phainein 'to show', and typos 'type'. Normally it refers to the presentation of a trait in an individual, but in this case it means the presentation of a disease entity.
^Scheuermann, Richard H.; Ceusters, Werner; Smith, Barry (2009-03-01). "Toward an Ontological Treatment of Disease and Diagnosis". Summit on Translational Bioinformatics. 2009: 116–120. PMC3041577. PMID 21347182.
^Russell, CD; Baillie, JK (April 2017). "Treatable traits and therapeutic targets: Goals for systems biology in infectious disease". Current Opinion in Systems Biology. 2: 140–146. doi:10.1016/j.coisb.2017.04.003. ISSN 2452-3100. PMC7185428. PMID 32363252.
^Miravitlles, Marc; Calle, Myriam; Soler-Cataluña, Juan José (2012-03-01). "Clinical Phenotypes of COPD: Identification, Definition and Implications for Guidelines". Archivos de Bronconeumología. 48 (3) (English ed.): 86–98. doi:10.1016/j.arbr.2012.01.003. PMID 22196477.
^Bel, Elisabeth H. (January 2004). "Clinical phenotypes of asthma". Current Opinion in Pulmonary Medicine. 10 (1): 44–50. doi:10.1097/00063198-200401000-00008. PMID 14749605.
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phenotype, clinical, medicine, other, uses, phenotype, disambiguation, nosological, sense, term, phenotype, used, clinical, medicine, speaking, about, presentation, disease, complementary, concept, this, regard, endotype, which, refers, pathogenesis, disease, . For other uses see Phenotype disambiguation In a nosological sense the term phenotype can be used in clinical medicine for speaking about the presentation of a disease 1 The complementary concept in this regard is endotype which refers to the pathogenesis of the disease ignoring its presentation 2 In this context a phenotype would be any observable characteristic or trait of a disease such as morphology development biochemical or physiological properties or behavior without any implication of a mechanism A clinical phenotype would be the presentation of a disease in a given individual citation needed Some organizations have their own specialised meaning For example the term phenotype in the field of chronic obstructive pulmonary disease COPD means a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes 3 but nearly all specialities use this meaning in some way like in asthma research 4 Etymology editThe word phenotype comes from Greek phainein to show and typos type Normally it refers to the presentation of a trait in an individual but in this case it means the presentation of a disease entity See also editClinical case definition Clinical disease Component causes Heterogeneous condition SyndromeReferences edit Scheuermann Richard H Ceusters Werner Smith Barry 2009 03 01 Toward an Ontological Treatment of Disease and Diagnosis Summit on Translational Bioinformatics 2009 116 120 PMC 3041577 PMID 21347182 Russell CD Baillie JK April 2017 Treatable traits and therapeutic targets Goals for systems biology in infectious disease Current Opinion in Systems Biology 2 140 146 doi 10 1016 j coisb 2017 04 003 ISSN 2452 3100 PMC 7185428 PMID 32363252 Miravitlles Marc Calle Myriam Soler Cataluna Juan Jose 2012 03 01 Clinical Phenotypes of COPD Identification Definition and Implications for Guidelines Archivos de Bronconeumologia 48 3 English ed 86 98 doi 10 1016 j arbr 2012 01 003 PMID 22196477 Bel Elisabeth H January 2004 Clinical phenotypes of asthma Current Opinion in Pulmonary Medicine 10 1 44 50 doi 10 1097 00063198 200401000 00008 PMID 14749605 nbsp This medical article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Phenotype clinical medicine amp oldid 1176357726, wikipedia, wiki, book, books, library,
