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Clement Finch

April 12, 2024

Clement Alfred Finch (July 4, 1915 – June 28, 2010) was an American physician specializing in hematology whose research on iron metabolism in the bloodstream at the University of Washington led to significant advancements in accurately diagnosing and treating anemia during a time period in which little was known about this aspect of the body. Finch was distinctively noted for using himself as a test subject by taking blood and bone marrow from his own bones before conducting similar tests on patients.[1] He graduated in 1941 from the University of Rochester Medical School and a year later was married to the first of three wives.[2] He experienced a 60-year tenure at the University of Washington, and has published many scholarly articles pertaining to iron in the bloodstream and is the author of three books entitled: Iron Metabolism (1962), Red Cell Manual (1969) and Fulfilling the Dream: A History of the University of Washington School of Medicine 1946 to 1988 (1990). Finch was elected as a Fellow of the National Academy of Sciences in 1974, and elected as a Fellow of the American Academy of Arts and Sciences in 1976.

Clement Finch
Born
Clement Alfred Finch

July 4, 1915
Broadalbin, New York, U.S.
DiedJune 28, 2010 (2010-06-29) (aged 94)
La Jolla, San Diego, California, U.S.
NationalityAmerican
Alma materUnion College
University of Rochester
Known forFirst chief of hematology at University of Washington
Scientific career
FieldsHematology
InstitutionsUniversity of Washington
Notable studentsEloise Giblett

Finch's studies are importantly recognized as significant in helping the World Health Organization make dietary recommendations for developing countries to aid in preventing anemia and poor development.[3]

Early life edit

Finch was born in Broadalbin, New York, on July 4, 1915, into a line of physicians which included both his father and grandfather.[2] Having accompanied his father on many occasions to house calls, he decided to follow in his father and grandfather's footsteps. Finch graduated from Union College in 1936 and enrolled at the University of Rochester Medical School in the late 1930s, from which he worked with Nobel Prize-winner George Whipple and published his first paper on hemoglobin regeneration in dogs in the Journal of Experimental Medicine as a second-year student.[2] He was a third-generation physician in his family. Finch married three times and had two divorces.[2] After the University of Rochester Medical School, Finch accepted a fellowship with Joe Ross at Boston University. Ross is responsible for introducing Finch to academic medicine, collaborating on work on iron metabolism and blood preservation which was relevant to the political setting of the time with the nation at war. Finch conducted post-graduate work at Brigham and Women's Hospital in Boston, working with acclaimed physicians such as Soma Weiss, Eugene A. Stead and Charles Janeway.[2] In 1948 after not being able to join the military due to pneumonia, Finch started his career at the University of Washington, which he preferred for the landscape and surrounding environment which offered him access to his favorite hobbies such as mountain climbing. One year later in 1949, he became University of Washington's first Chief of Hematology.[2]

Research edit

Finch's research on how iron metabolizes in the blood helped with blood disorders characterized by either an excess or inadequate supply of iron in the blood stream, such as anemia and hemochromatosis, and also focused his work on further understanding erythropoiesis, a process by which red blood cells are produced. During a period in which little was known about iron-deficiency anemia, how often it occurred or the principles of iron metabolism, Finch made significant findings in his research at the University of Washington throughout his 60-year tenure using radioisotopes to measure the body's production of red cells and their life span.[1] He was able to discover how iron is incorporated in hemoglobin, and was able to aid doctors in expanding their abilities from simply detecting iron-deficiency anemia to detecting different types of anemia in an increasingly accurate manner.[1] Finch has published Scientific Journal articles specifically pertaining to Erythropoiesis and anemia such as Erythropoiesisin Pernicious Anemia (1953), Treatment of Iron Deficiency Anemia in the Adult (1957), The Diagnosing of Iron deficiency Anemia (1964), Pathophysiologic Aspects of Sickle Cell Anemia (1972), and Erythroid Marrow Function in Anemic Patients (1987). Additional articles included: The Effect of Erythroid Hyperplasia on iron balance (1988), and Intact Transferrin Receptors in Human Plasma and Their Relation to Erythropoisis in blood (1990).

Transferrin, a blood plasma protein for iron ion delivery, was a topic for Finch in the 1980s.[4] He researched and published studies on transferrin in the blood such as intact transferrin receptors in human plasma, human deferric transferrin's interaction with reticulocytes, the uptake and release of iron in human transferrin, rat transferrin and gene expression, the iron binding sites of human transferrin, its saturation, and clinical implications.

Other studies conducted by Finch showed how iron is used in the blood to manufacture hemoglobin. He additionally showed that hemochromatosis which causes the body to absorb too much iron from food consumption could be treated through periodic bleeding.[5] He described how the body tries to maintain adequate stores after significant iron stores are depleted during menstruation and recommended that most women take supplements to prevent them from suffering signs of iron deficiency such as fatigue.[6] He showed how to extend the life of blood stored to transfuse injured soldiers, work inspired by his desire to help serve his country after being unable to serve in the military.

Research in the early 1960s by Finch showed that most women were not getting enough iron in their diet and suggested that supplements be taken by women to avoid problems such as fatigue caused by iron deficiency.

Death edit

Finch died on June 28, 2010, at his home in the La Jolla neighborhood of San Diego at the age of 94 and is survived by his wife Genia Finch, two children from his first marriage, Clifton Finch and Carin Finch Barber, two children from his third marriage, Lisa Finch and Darel Finch, and three grandchildren.[1]

Publications edit

  • Finch, Clement A. (1969). Red Cell Manual. Seattle: University of Washington. OCLC 11196233.
  • Finch, Clement A. (1990). Fulfilling the Dream: A History of the University of Washington School of Medicine, 1946–1988. Seattle: Medical Alumni Association. ISBN 9780803646339. OCLC 22870961.
  • Skarberg, Karl; Eng, Mary; Huebers, Helmut; Marsaglia, George; Finch, Clement (1978). "Plasma radioiron kinetics in man: explanation for the effect of plasma iron concentration". Proceedings of the National Academy of Sciences. 75 (3): 1559–1561. Bibcode:1978PNAS...75.1559S. doi:10.1073/pnas.75.3.1559. JSTOR 68042. PMC 411513. PMID 274740.
  • Huebers, Helmut; Csiba, Eva; Josephson, Betty; Huebers, Eiko; Finch, Clement (1981). "Interaction of Human Diferric Transferrin with Reticulocytes". Proceedings of the National Academy of Sciences. 78 (1): 621–625. Bibcode:1981PNAS...78..621H. doi:10.1073/pnas.78.1.621. JSTOR 10098. PMC 319106. PMID 6264452.
  • Huebers, Helmut; Josephson, Betty; Huebers, Eiko; Csiba, Eva; Finch, Clement (1981). "Uptake and Release of Iron from Human Transferrin". Proceedings of the National Academy of Sciences. 78 (4): 2572–2576. Bibcode:1981PNAS...78.2572H. doi:10.1073/pnas.78.4.2572. JSTOR 10221. PMC 319391. PMID 6941310.
  • Huebers, Helmut; Csiba, Eva; Huebers, Eiko; Finch, Clement (1983). "Competitive Advantage of Diferric Transferrin in Delivering Iron to Reticulocytes". Proceedings of the National Academy of Sciences. 80 (1): 300–304. Bibcode:1983PNAS...80..300H. doi:10.1073/pnas.80.1.300. JSTOR 13372. PMC 393361. PMID 6572005.
  • Idzerda, Rejean L.; Huebers, Helmut; Finch, Clement A.; McKnight, G. Stanley (1986). "Rat Transferrin Gene Expression: Tissue-Specific Regulation by Iron Deficiency". Proceedings of the National Academy of Sciences. 83 (11): 3723–3727. Bibcode:1986PNAS...83.3723I. doi:10.1073/pnas.83.11.3723. JSTOR 27758. PMC 323595. PMID 3459151.
  • Huebers, Helmut; Josephson, Betty; Huebers, Eiko; Csiba, Eva; Finch, Clement (1984). "Occupancy of the Iron Binding Sites of Human Transferrin". Proceedings of the National Academy of Sciences. 81 (14): 4326–4330. Bibcode:1984PNAS...81.4326H. doi:10.1073/pnas.81.14.4326. JSTOR 24260. PMC 345581. PMID 6589596.
  • Pirzio-Biroli, G.; Finch, Clement A. (1957). "Treatment of iron deficiency anemia in the adult". Journal of Chronic Diseases. 6 (4–5): 302–306. doi:10.1016/0021-9681(57)90025-5. PMID 13475435.
  • Coleman, Daniel H.; Clement A. Finch (1953). "Erythropoiesis in pernicious anemia". American Journal of Medicine. 15 (3): 412. doi:10.1016/0002-9343(53)90104-1.
  • Bainton, Dorothy Ford; Clement A. Finch (1964). "The diagnosis of iron deficiency anemia". American Journal of Medicine. 37 (1): 62–70. doi:10.1016/0002-9343(64)90212-8. PMID 14181150.
  • Body iron excretion in man: A collaborative study
The American Journal of Medicine, Volume 45, Issue 3, September 1968, Pages 336-353
Ralph Green, Robert Charlton, Harold Seftel, Thomas Bothwell, Fatima Mayet, Barry Adams, Clement Finch, Miguel Layrisse
  • Evaluation of storage iron by chelates
The American Journal of Medicine, Volume 45, Issue 1, July 1968, Pages 105-115
Laurence A. Harker, Donald D. Funk, Clement A. Finch
  • Iron stores in man
The American Journal of Medicine, Volume 11, Issue 5, November 1951, Page 629
Alexander R. Stevens Jr., Clement A. Finch
  • Iron storage disease
Journal of Chronic Diseases, Volume 2, Issue 2, August 1955, Pages 232-233
Clement A. Finch
  • Clinical syndrome of potassium intoxication
The American Journal of Medicine, Volume 1, Issue 4, October 1946, Pages 337-352
Clement A. Finch, C.Glenn Sawyer, John M. Flynn
  • Pathophysiologic aspects of sickle cell anemia
The American Journal of Medicine, Volume 53, Issue 1, July 1972, Pages 1-6
Clement A. Finch
  • Effects of iron status on δ-aminolevulinic acid dehydratase activity
Biochemical Medicine, Volume 18, Issue 3, December 1977, Pages 323-329
Robert F. Labbé, Clement A. Finch
  • Intact transferrin receptors in human plasma and their relation to erythropoiesis
Blood, Jan 1990; 75: 102 – 107. HA Huebers, Y Beguin, P Pootrakul, D Einspahr, and CA Finch
  • Quantitation of ferritin iron in plasma, an explanation for non- transferrin iron
Blood, Apr 1988; 71: 1120 - 1123. P Pootrakul, B Josephson, HA Huebers, and CA Finch
  • The effect of erythroid hyperplasia on iron balance
Blood, Apr 1988; 71: 1124 - 1129. P Pootrakul, K Kitcharoen, P Yansukon, P Wasi, S Fucharoen, P Charoenlarp, G Brittenham, MJ Pippard, and CA Finch
  • Erythroid marrow function in anemic patients
Blood, Jan 1987; 69: 296 – 301. M Cazzola, P Pootrakul, HA Huebers, M Eng, J Eschbach, and CA Finch
  • Transferrin saturation, plasma iron turnover, and transferrin uptake in normal humans
Blood, Oct 1985; 66: 935 - 939. M Cazzola, HA Huebers, MH Sayers, AP MacPhail, M Eng, and CA Finch
  • A mono-sited transferrin from a representative deuterostome: the ascidian Pyura stolonifera (subphylum Urochordata)
AW Martin, E Huebers, H Huebers, J Webb, and CA Finch
Blood, Nov 1984; 64: 1047 - 1052.
  • Transferrin: physiologic behavior and clinical implications
HA Huebers and CA Finch
Blood, Oct 1984; 64: 763 - 767.
  • The significance of transferrin for intestinal iron absorption
HA Huebers, E Huebers, E Csiba, W Rummel, and CA Finch
Blood, Feb 1983; 61: 283 - 290.
  • Ferrioxamine excretion in iron-loaded man
MJ Pippard, ST Callender, and CA Finch
Blood, Aug 1982; 60: 288 - 294.

References edit

  1. ^ a b c d Altman, Lawrence K. "Clement Finch, a Pioneer in Hematology, Dies at 94", The New York Times, July 5, 2010. Accessed July 26, 2010.
  2. ^ a b c d e f Adamson, John W. MD "Clement Finch: A Unique Man at a Unique Time", American Society of Hematology, November 1, 2008. Accessed July 26, 2010.
  3. ^ Maugh, Thomas H., II. "Clement A. Finch dies at 94; pioneering hematologist", Los Angeles Times, July 14, 2010. Accessed on July 26, 2010.
  4. ^ See List of Publications, above.
  5. ^ Marie Warder - The Bronze Killer
  6. ^ Nelson, Harry. "Most Women Need An Iron Supplement", St. Petersburg Times, February 23, 1960. Accessed July 26, 2010.

April 12, 2024
clement, finch, clement, alfred, finch, july, 1915, june, 2010, american, physician, specializing, hematology, whose, research, iron, metabolism, bloodstream, university, washington, significant, advancements, accurately, diagnosing, treating, anemia, during, . Clement Alfred Finch July 4 1915 June 28 2010 was an American physician specializing in hematology whose research on iron metabolism in the bloodstream at the University of Washington led to significant advancements in accurately diagnosing and treating anemia during a time period in which little was known about this aspect of the body Finch was distinctively noted for using himself as a test subject by taking blood and bone marrow from his own bones before conducting similar tests on patients 1 He graduated in 1941 from the University of Rochester Medical School and a year later was married to the first of three wives 2 He experienced a 60 year tenure at the University of Washington and has published many scholarly articles pertaining to iron in the bloodstream and is the author of three books entitled Iron Metabolism 1962 Red Cell Manual 1969 and Fulfilling the Dream A History of the University of Washington School of Medicine 1946 to 1988 1990 Finch was elected as a Fellow of the National Academy of Sciences in 1974 and elected as a Fellow of the American Academy of Arts and Sciences in 1976 Clement FinchBornClement Alfred FinchJuly 4 1915Broadalbin New York U S DiedJune 28 2010 2010 06 29 aged 94 La Jolla San Diego California U S NationalityAmericanAlma materUnion CollegeUniversity of RochesterKnown forFirst chief of hematology at University of WashingtonScientific careerFieldsHematologyInstitutionsUniversity of WashingtonNotable studentsEloise GiblettFinch s studies are importantly recognized as significant in helping the World Health Organization make dietary recommendations for developing countries to aid in preventing anemia and poor development 3 Contents 1 Early life 2 Research 3 Death 4 Publications 5 ReferencesEarly life editFinch was born in Broadalbin New York on July 4 1915 into a line of physicians which included both his father and grandfather 2 Having accompanied his father on many occasions to house calls he decided to follow in his father and grandfather s footsteps Finch graduated from Union College in 1936 and enrolled at the University of Rochester Medical School in the late 1930s from which he worked with Nobel Prize winner George Whipple and published his first paper on hemoglobin regeneration in dogs in the Journal of Experimental Medicine as a second year student 2 He was a third generation physician in his family Finch married three times and had two divorces 2 After the University of Rochester Medical School Finch accepted a fellowship with Joe Ross at Boston University Ross is responsible for introducing Finch to academic medicine collaborating on work on iron metabolism and blood preservation which was relevant to the political setting of the time with the nation at war Finch conducted post graduate work at Brigham and Women s Hospital in Boston working with acclaimed physicians such as Soma Weiss Eugene A Stead and Charles Janeway 2 In 1948 after not being able to join the military due to pneumonia Finch started his career at the University of Washington which he preferred for the landscape and surrounding environment which offered him access to his favorite hobbies such as mountain climbing One year later in 1949 he became University of Washington s first Chief of Hematology 2 Research editFinch s research on how iron metabolizes in the blood helped with blood disorders characterized by either an excess or inadequate supply of iron in the blood stream such as anemia and hemochromatosis and also focused his work on further understanding erythropoiesis a process by which red blood cells are produced During a period in which little was known about iron deficiency anemia how often it occurred or the principles of iron metabolism Finch made significant findings in his research at the University of Washington throughout his 60 year tenure using radioisotopes to measure the body s production of red cells and their life span 1 He was able to discover how iron is incorporated in hemoglobin and was able to aid doctors in expanding their abilities from simply detecting iron deficiency anemia to detecting different types of anemia in an increasingly accurate manner 1 Finch has published Scientific Journal articles specifically pertaining to Erythropoiesis and anemia such as Erythropoiesisin Pernicious Anemia 1953 Treatment of Iron Deficiency Anemia in the Adult 1957 The Diagnosing of Iron deficiency Anemia 1964 Pathophysiologic Aspects of Sickle Cell Anemia 1972 and Erythroid Marrow Function in Anemic Patients 1987 Additional articles included The Effect of Erythroid Hyperplasia on iron balance 1988 and Intact Transferrin Receptors in Human Plasma and Their Relation to Erythropoisis in blood 1990 Transferrin a blood plasma protein for iron ion delivery was a topic for Finch in the 1980s 4 He researched and published studies on transferrin in the blood such as intact transferrin receptors in human plasma human deferric transferrin s interaction with reticulocytes the uptake and release of iron in human transferrin rat transferrin and gene expression the iron binding sites of human transferrin its saturation and clinical implications Other studies conducted by Finch showed how iron is used in the blood to manufacture hemoglobin He additionally showed that hemochromatosis which causes the body to absorb too much iron from food consumption could be treated through periodic bleeding 5 He described how the body tries to maintain adequate stores after significant iron stores are depleted during menstruation and recommended that most women take supplements to prevent them from suffering signs of iron deficiency such as fatigue 6 He showed how to extend the life of blood stored to transfuse injured soldiers work inspired by his desire to help serve his country after being unable to serve in the military Research in the early 1960s by Finch showed that most women were not getting enough iron in their diet and suggested that supplements be taken by women to avoid problems such as fatigue caused by iron deficiency Death editFinch died on June 28 2010 at his home in the La Jolla neighborhood of San Diego at the age of 94 and is survived by his wife Genia Finch two children from his first marriage Clifton Finch and Carin Finch Barber two children from his third marriage Lisa Finch and Darel Finch and three grandchildren 1 Publications editFinch Clement A 1969 Red Cell Manual Seattle University of Washington OCLC 11196233 7th ed F A Davis 1996 ISBN 0 8036 0145 X Finch Clement A 1990 Fulfilling the Dream A History of the University of Washington School of Medicine 1946 1988 Seattle Medical Alumni Association ISBN 9780803646339 OCLC 22870961 Skarberg Karl Eng Mary Huebers Helmut Marsaglia George Finch Clement 1978 Plasma radioiron kinetics in man explanation for the effect of plasma iron concentration Proceedings of the National Academy of Sciences 75 3 1559 1561 Bibcode 1978PNAS 75 1559S doi 10 1073 pnas 75 3 1559 JSTOR 68042 PMC 411513 PMID 274740 Huebers Helmut Csiba Eva Josephson Betty Huebers Eiko Finch Clement 1981 Interaction of Human Diferric Transferrin with Reticulocytes Proceedings of the National Academy of Sciences 78 1 621 625 Bibcode 1981PNAS 78 621H doi 10 1073 pnas 78 1 621 JSTOR 10098 PMC 319106 PMID 6264452 Huebers Helmut Josephson Betty Huebers Eiko Csiba Eva Finch Clement 1981 Uptake and Release of Iron from Human Transferrin Proceedings of the National Academy of Sciences 78 4 2572 2576 Bibcode 1981PNAS 78 2572H doi 10 1073 pnas 78 4 2572 JSTOR 10221 PMC 319391 PMID 6941310 Huebers Helmut Csiba Eva Huebers Eiko Finch Clement 1983 Competitive Advantage of Diferric Transferrin in Delivering Iron to Reticulocytes Proceedings of the National Academy of Sciences 80 1 300 304 Bibcode 1983PNAS 80 300H doi 10 1073 pnas 80 1 300 JSTOR 13372 PMC 393361 PMID 6572005 Idzerda Rejean L Huebers Helmut Finch Clement A McKnight G Stanley 1986 Rat Transferrin Gene Expression Tissue Specific Regulation by Iron Deficiency Proceedings of the National Academy of Sciences 83 11 3723 3727 Bibcode 1986PNAS 83 3723I doi 10 1073 pnas 83 11 3723 JSTOR 27758 PMC 323595 PMID 3459151 Huebers Helmut Josephson Betty Huebers Eiko Csiba Eva Finch Clement 1984 Occupancy of the Iron Binding Sites of Human Transferrin Proceedings of the National Academy of Sciences 81 14 4326 4330 Bibcode 1984PNAS 81 4326H doi 10 1073 pnas 81 14 4326 JSTOR 24260 PMC 345581 PMID 6589596 Pirzio Biroli G Finch Clement A 1957 Treatment of iron deficiency anemia in the adult Journal of Chronic Diseases 6 4 5 302 306 doi 10 1016 0021 9681 57 90025 5 PMID 13475435 Coleman Daniel H Clement A Finch 1953 Erythropoiesis in pernicious anemia American Journal of Medicine 15 3 412 doi 10 1016 0002 9343 53 90104 1 Bainton Dorothy Ford Clement A Finch 1964 The diagnosis of iron deficiency anemia American Journal of Medicine 37 1 62 70 doi 10 1016 0002 9343 64 90212 8 PMID 14181150 Body iron excretion in man A collaborative studyThe American Journal of Medicine Volume 45 Issue 3 September 1968 Pages 336 353 Ralph Green Robert Charlton Harold Seftel Thomas Bothwell Fatima Mayet Barry Adams Clement Finch Miguel LayrisseEvaluation of storage iron by chelatesThe American Journal of Medicine Volume 45 Issue 1 July 1968 Pages 105 115 Laurence A Harker Donald D Funk Clement A FinchIron stores in manThe American Journal of Medicine Volume 11 Issue 5 November 1951 Page 629 Alexander R Stevens Jr Clement A FinchIron storage diseaseJournal of Chronic Diseases Volume 2 Issue 2 August 1955 Pages 232 233 Clement A FinchClinical syndrome of potassium intoxicationThe American Journal of Medicine Volume 1 Issue 4 October 1946 Pages 337 352 Clement A Finch C Glenn Sawyer John M FlynnPathophysiologic aspects of sickle cell anemiaThe American Journal of Medicine Volume 53 Issue 1 July 1972 Pages 1 6 Clement A FinchEffects of iron status on d aminolevulinic acid dehydratase activityBiochemical Medicine Volume 18 Issue 3 December 1977 Pages 323 329 Robert F Labbe Clement A FinchIntact transferrin receptors in human plasma and their relation to erythropoiesisBlood Jan 1990 75 102 107 HA Huebers Y Beguin P Pootrakul D Einspahr and CA FinchQuantitation of ferritin iron in plasma an explanation for non transferrin ironBlood Apr 1988 71 1120 1123 P Pootrakul B Josephson HA Huebers and CA FinchThe effect of erythroid hyperplasia on iron balanceBlood Apr 1988 71 1124 1129 P Pootrakul K Kitcharoen P Yansukon P Wasi S Fucharoen P Charoenlarp G Brittenham MJ Pippard and CA FinchErythroid marrow function in anemic patientsBlood Jan 1987 69 296 301 M Cazzola P Pootrakul HA Huebers M Eng J Eschbach and CA FinchTransferrin saturation plasma iron turnover and transferrin uptake in normal humansBlood Oct 1985 66 935 939 M Cazzola HA Huebers MH Sayers AP MacPhail M Eng and CA FinchA mono sited transferrin from a representative deuterostome the ascidian Pyura stolonifera subphylum Urochordata AW Martin E Huebers H Huebers J Webb and CA Finch Blood Nov 1984 64 1047 1052 Transferrin physiologic behavior and clinical implicationsHA Huebers and CA Finch Blood Oct 1984 64 763 767 The significance of transferrin for intestinal iron absorptionHA Huebers E Huebers E Csiba W Rummel and CA Finch Blood Feb 1983 61 283 290 Ferrioxamine excretion in iron loaded manMJ Pippard ST Callender and CA Finch Blood Aug 1982 60 288 294 References edit a b c d Altman Lawrence K Clement Finch a Pioneer in Hematology Dies at 94 The New York Times July 5 2010 Accessed July 26 2010 a b c d e f Adamson John W MD Clement Finch A Unique Man at a Unique Time American Society of Hematology November 1 2008 Accessed July 26 2010 Maugh Thomas H II Clement A Finch dies at 94 pioneering hematologist Los Angeles Times July 14 2010 Accessed on July 26 2010 See List of Publications above Marie Warder The Bronze Killer Nelson Harry Most Women Need An Iron Supplement St Petersburg Times February 23 1960 Accessed July 26 2010 Retrieved from https en wikipedia org w index php title Clement Finch amp oldid 1198012029, wikipedia, wiki, book, books, library,

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