Cholesteryl ester, a dietary lipid, is an ester of cholesterol. The ester bond is formed between the carboxylate group of a fatty acid and the hydroxyl group of cholesterol. Cholesteryl esters have a lower solubility in water due to their increased hydrophobicity. Esters are formed by replacing at least one –OH (hydroxyl) group with an –O–alkyl (alkoxy) group. They are hydrolyzed by pancreatic enzymes, cholesterol esterase, to produce cholesterol and free fatty acids.[1] They are associated with atherosclerosis.[2]
Cholesterol oleate, a member of the cholesteryl ester family
Cholesteryl ester is found in human brains as lipid droplets which store and transport cholesterol.[3] Increased levels of cholesteryl ester have been found in certain parts of the brain of people with Huntington disease. Higher concentrations of cholesteryl ester have been found in the caudate and putamen, but not the cerebellum, of people with Huntington disease compared with levels in controls.[4] Increase in cholesteryl ester has also been found in other neurological disorders like multiple sclerosis and Alzheimer’s disease.[3]
^ abPhillips, Gabrielle R.; Hancock, Sarah E.; Brown, Simon H. J.; Jenner, Andrew M.; Kreilaus, Fabian; Newell, Kelly A.; Mitchell, Todd W. (2020-11-20). "Cholesteryl ester levels are elevated in the caudate and putamen of Huntington's disease patients". Scientific Reports. 10 (1): 20314. Bibcode:2020NatSR..1020314P. doi:10.1038/s41598-020-76973-8. ISSN 2045-2322. PMC7680097. PMID 33219259.
^"Illawarra Health and Medical Research Institute Researchers Report on Findings in Huntington Disease (Cholesteryl ester levels are elevated in the caudate and putamen of Huntington's disease patients) (Cholesteryl ester levels are elevated in ...)." Obesity, Fitness & Wellness Week, 2020, p. 2684. Gale Academic OneFile, link.gale.com/apps/doc/A643924682/AONE?u=cuny_hunter&sid=AONE&xid=6782d457. Accessed 2 May 2021.
This biochemistry article is a stub. You can help Wikipedia by expanding it.
cholesteryl, ester, dietary, lipid, ester, cholesterol, ester, bond, formed, between, carboxylate, group, fatty, acid, hydroxyl, group, cholesterol, have, lower, solubility, water, their, increased, hydrophobicity, esters, formed, replacing, least, hydroxyl, g. Cholesteryl ester a dietary lipid is an ester of cholesterol The ester bond is formed between the carboxylate group of a fatty acid and the hydroxyl group of cholesterol Cholesteryl esters have a lower solubility in water due to their increased hydrophobicity Esters are formed by replacing at least one OH hydroxyl group with an O alkyl alkoxy group They are hydrolyzed by pancreatic enzymes cholesterol esterase to produce cholesterol and free fatty acids 1 They are associated with atherosclerosis 2 Cholesterol oleate a member of the cholesteryl ester familyCholesteryl ester is found in human brains as lipid droplets which store and transport cholesterol 3 Increased levels of cholesteryl ester have been found in certain parts of the brain of people with Huntington disease Higher concentrations of cholesteryl ester have been found in the caudate and putamen but not the cerebellum of people with Huntington disease compared with levels in controls 4 Increase in cholesteryl ester has also been found in other neurological disorders like multiple sclerosis and Alzheimer s disease 3 See also editCholesteryl ester transfer protein Cholesteryl ester storage disease Acyl CoA cholesteryl acyltransferase ACAT Lecithin cholesterol acyltransferase LCAT References edit Ferrier Richard A Harvey Denise R 2011 Lippincott s illustrated reviews biochemistry 5th ed Philadelphia Wolters Kluwer Health p 175 ISBN 9781608314126 a href Template Cite book html title Template Cite book cite book a CS1 maint multiple names authors list link Cholesterol Esters at the U S National Library of Medicine Medical Subject Headings MeSH a b Phillips Gabrielle R Hancock Sarah E Brown Simon H J Jenner Andrew M Kreilaus Fabian Newell Kelly A Mitchell Todd W 2020 11 20 Cholesteryl ester levels are elevated in the caudate and putamen of Huntington s disease patients Scientific Reports 10 1 20314 Bibcode 2020NatSR 1020314P doi 10 1038 s41598 020 76973 8 ISSN 2045 2322 PMC 7680097 PMID 33219259 Illawarra Health and Medical Research Institute Researchers Report on Findings in Huntington Disease Cholesteryl ester levels are elevated in the caudate and putamen of Huntington s disease patients Cholesteryl ester levels are elevated in Obesity Fitness amp Wellness Week 2020 p 2684 Gale Academic OneFile link gale com apps doc A643924682 AONE u cuny hunter amp sid AONE amp xid 6782d457 Accessed 2 May 2021 nbsp This biochemistry article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Cholesteryl ester amp oldid 1168221436, wikipedia, wiki, book, books, library,
