Chlordiazepoxide/clidinium bromide (marketed as Librax) is a fixed-dose combination medication used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis.[2] It contains chlordiazepoxide and clidinium bromide. It helps relieve stomach spasms, abdominal cramps, and anxiety related to gastric disorders.[3] Librax is a fixed ratio of these two medications and, as such, is not typically prescribed with an accompanying dosage, but rather directions on how many capsules to take per day. It comes in a capsule taken by mouth, usually three or four times daily, before meals and at bedtime.[3] Chlordiazepoxide is an anti-anxiety medication belonging to the benzodiazepine class.[4] Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic,[5] a sub-class of a family of drugs known as anticholinergics. It treats IBS by decreasing gastrointestinal motility.
Chlordiazepoxide can be habit-forming. Tolerance may develop with long-term or excessive use, making this medication less effective. This medication must be taken regularly to be effective. Stopping the drug suddenly can worsen the condition and cause withdrawal symptoms (anxiousness, sleeplessness, and irritability).[3]
It was approved for medical use in the United States in 1966.[6][7] It is available as a generic medication.[8]
Medical usesedit
Chlordiazepoxide/clidinium bromide is indicated to control emotional and somatic factors in gastrointestinal disorders.[7] It may also be used as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.[7]
Referencesedit
^"Chlordiazepoxide / clidinium Use During Pregnancy". Drugs.com. 18 September 2019. Retrieved 15 August 2020.
^Donnelly P (2010). "Gasterointestinal Drugs". Nurse's Handbook of Combination Drugs (2nd ed.). Sudbury, Mass.: Jones and Bartlett Publishers. p. 537. ISBN978-0-7637-6549-1.
^ abc"Librax". MedlinePlus: US National library of medicine. Retrieved 31 May 2013.
chlordiazepoxide, clidinium, bromide, marketed, librax, fixed, dose, combination, medication, used, treat, peptic, ulcers, irritable, bowel, syndrome, gastritis, contains, chlordiazepoxide, clidinium, bromide, helps, relieve, stomach, spasms, abdominal, cramps. Chlordiazepoxide clidinium bromide marketed as Librax is a fixed dose combination medication used to treat peptic ulcers irritable bowel syndrome IBS and gastritis 2 It contains chlordiazepoxide and clidinium bromide It helps relieve stomach spasms abdominal cramps and anxiety related to gastric disorders 3 Librax is a fixed ratio of these two medications and as such is not typically prescribed with an accompanying dosage but rather directions on how many capsules to take per day It comes in a capsule taken by mouth usually three or four times daily before meals and at bedtime 3 Chlordiazepoxide is an anti anxiety medication belonging to the benzodiazepine class 4 Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety Clidinium bromide is a synthetic quaternary ammonium antimuscarinic 5 a sub class of a family of drugs known as anticholinergics It treats IBS by decreasing gastrointestinal motility Chlordiazepoxide clidinium bromideCombination ofChlordiazepoxideAnxiolyticClidinium bromideAntimuscarinicClinical dataTrade namesLibraxAHFS Drugs comMicromedex Detailed Consumer InformationMedlinePlusa601036Routes ofadministrationBy mouthATC codeA03CA02 WHO Legal statusLegal statusUS onlyIdentifiersCAS Number8015 20 1 YPubChem CID3080646ChemSpider2338393 YKEGGD10247CompTox Dashboard EPA DTXSID501000995 verify Chlordiazepoxide can be habit forming Tolerance may develop with long term or excessive use making this medication less effective This medication must be taken regularly to be effective Stopping the drug suddenly can worsen the condition and cause withdrawal symptoms anxiousness sleeplessness and irritability 3 It was approved for medical use in the United States in 1966 6 7 It is available as a generic medication 8 Medical uses editChlordiazepoxide clidinium bromide is indicated to control emotional and somatic factors in gastrointestinal disorders 7 It may also be used as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome irritable colon spastic colon mucous colitis and acute enterocolitis 7 References edit Chlordiazepoxide clidinium Use During Pregnancy Drugs com 18 September 2019 Retrieved 15 August 2020 Donnelly P 2010 Gasterointestinal Drugs Nurse s Handbook of Combination Drugs 2nd ed Sudbury Mass Jones and Bartlett Publishers p 537 ISBN 978 0 7637 6549 1 a b c Librax MedlinePlus US National library of medicine Retrieved 31 May 2013 Chlordiazepoxide MedScape Clidinium Drugs com Librax FDA Approved Drugs U S Food and Drug Administration FDA Retrieved 15 August 2020 a b c Librax chlordiazepoxide hydrochloride and clidinium bromide capsule DailyMed 31 May 2020 Retrieved 15 August 2020 Chlordiazepoxide hydrochloride and clidinium bromide FDA Approved Drugs U S Food and Drug Administration FDA Retrieved 15 August 2020 External links edit Chlordiazepoxide mixture with clidinium bromide Drug Information Portal U S National Library of Medicine Portal nbsp Medicine nbsp This drug article relating to the gastrointestinal system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Chlordiazepoxide clidinium bromide amp oldid 1136011553, wikipedia, wiki, book, books, library,
