Caspase-2 (EC 3.4.22.55, ICH-1, NEDD-2, caspase-2L, caspase-2S, neural precursor cell expressed developmentally down-regulated protein 2, CASP-2, NEDD2 protein) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
Strict requirement for an Asp residue at P1, with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-
^Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA (July 1994). "Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme". Genes & Development. 8 (14): 1613–26. doi:10.1101/gad.8.14.1613. PMID 7958843.
^Wang L, Miura M, Bergeron L, Zhu H, Yuan J (September 1994). "Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death". Cell. 78 (5): 739–50. doi:10.1016/S0092-8674(94)90422-7. PMID 8087842.
^Li H, Bergeron L, Cryns V, Pasternack MS, Zhu H, Shi L, Greenberg A, Yuan J (August 1997). "Activation of caspase-2 in apoptosis". The Journal of Biological Chemistry. 272 (34): 21010–7. doi:10.1074/jbc.272.34.21010. PMID 9261102.
^Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA, Rosen A (May 2000). "Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis". The Journal of Cell Biology. 149 (3): 603–12. doi:10.1083/jcb.149.3.603. PMC2174848. PMID 10791974.
^Zhivotovsky B, Orrenius S (June 2005). "Caspase-2 function in response to DNA damage". Biochemical and Biophysical Research Communications. 331 (3): 859–67. doi:10.1016/j.bbrc.2005.03.191. PMID 15865942.
^Chang HY, Yang X (December 2000). "Proteases for cell suicide: functions and regulation of caspases". Microbiology and Molecular Biology Reviews. 64 (4): 821–46. doi:10.1128/mmbr.64.4.821-846.2000. PMC99015. PMID 11104820.
caspase, nedd, caspase, caspase, neural, precursor, cell, expressed, developmentally, down, regulated, protein, casp, nedd2, protein, enzyme, this, enzyme, catalyses, following, chemical, reactionidentifiersec, 55cas, 182372, 1databasesintenzintenz, viewbrenda. Caspase 2 EC 3 4 22 55 ICH 1 NEDD 2 caspase 2L caspase 2S neural precursor cell expressed developmentally down regulated protein 2 CASP 2 NEDD2 protein is an enzyme 1 2 3 4 5 6 This enzyme catalyses the following chemical reactionCaspase 2IdentifiersEC no 3 4 22 55CAS no 182372 14 1DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins Strict requirement for an Asp residue at P1 with Asp316 being essential for proteolytic activity and has a preferred cleavage sequence of Val Asp Val Ala Asp Caspase 2 is an initiator caspase as are caspase 8 EC 3 4 22 61 caspase 9 EC 3 4 22 62 and caspase 10 EC 3 4 22 63 References edit Kumar S Kinoshita M Noda M Copeland NG Jenkins NA July 1994 Induction of apoptosis by the mouse Nedd2 gene which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced 3 and the mammalian IL 1 beta converting enzyme Genes amp Development 8 14 1613 26 doi 10 1101 gad 8 14 1613 PMID 7958843 Wang L Miura M Bergeron L Zhu H Yuan J September 1994 Ich 1 an Ice ced 3 related gene encodes both positive and negative regulators of programmed cell death Cell 78 5 739 50 doi 10 1016 S0092 8674 94 90422 7 PMID 8087842 Li H Bergeron L Cryns V Pasternack MS Zhu H Shi L Greenberg A Yuan J August 1997 Activation of caspase 2 in apoptosis The Journal of Biological Chemistry 272 34 21010 7 doi 10 1074 jbc 272 34 21010 PMID 9261102 Mancini M Machamer CE Roy S Nicholson DW Thornberry NA Casciola Rosen LA Rosen A May 2000 Caspase 2 is localized at the Golgi complex and cleaves golgin 160 during apoptosis The Journal of Cell Biology 149 3 603 12 doi 10 1083 jcb 149 3 603 PMC 2174848 PMID 10791974 Zhivotovsky B Orrenius S June 2005 Caspase 2 function in response to DNA damage Biochemical and Biophysical Research Communications 331 3 859 67 doi 10 1016 j bbrc 2005 03 191 PMID 15865942 Chang HY Yang X December 2000 Proteases for cell suicide functions and regulation of caspases Microbiology and Molecular Biology Reviews 64 4 821 46 doi 10 1128 mmbr 64 4 821 846 2000 PMC 99015 PMID 11104820 External links editCaspase 2 at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title Caspase 2 amp oldid 1188149133, wikipedia, wiki, book, books, library,
