fbpx
Wikipedia

Calcium-dependent chloride channel

April 12, 2024

The Calcium-Dependent Chloride Channel (Ca-ClC) proteins (or calcium-activated chloride channels (CaCCs),[2] are heterogeneous groups of ligand-gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells. They include proteins from several structurally different families: chloride channel accessory (CLCA),[3] bestrophin (BEST),[4][5] and calcium-dependent chloride channel anoctamin (ANO or TMEM16) channels[4][5][6][7] ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal, which are proteins which serve as intestinal pacemakers for peristalsis.[6] In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors.[8] These eukaryotic proteins are "required for normal electrolyte and fluid secretion, olfactory perception, and neuronal and smooth muscle excitability" in animals.[9][10] Members of the Ca-CIC family are generally 600 to 1000 amino acyl residues (aas) in length and exhibit 7 to 10 transmembrane segments (TMSs).

TMEM16
Cartoon representation of a mTMEM16A chloride channel based on a cryoelectron microscopy reconstruction.[1]
Identifiers
SymbolApoctamin
PfamPF04547
InterProIPR032394
TCDB1.A.17
OPM superfamily369
Membranome219
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Function edit

Tmc1 and Tmc2 (TC#s 1.A.17.4.6 and 1.A.17.4.1, respectively) may play a role in hearing and are required for normal function of cochlear hair cells, possibly as Ca2+ channels or Ca2+ channel subunits (see also family TC# 1.A.82).[11] Mice lacking both channels lack hair cell mechanosensory potentials.[12] There are 8 members of this family in humans, 1 in Drosophila and 2 in C. elegans. One of the latter two is expressed in mechanoreceptors.[13] Tmc1 is a sodium-sensitive cation channel required for salt (Na+) chemosensation in C. elegans "where it is required for salt-evoked neuronal activity and behavioural avoidance of high concentrations of NaCl".[14]

TMEM16A is over-expressed in several tumor types. The role of TMEM16A in gliomas and the potential underlying mechanisms were analyzed by Liu et al. 2014. Knockdown of TMEM16A suppressed cell proliferation, migration and invasion.[15]

The reactions believed to be catalyzed by channels of the Ca-ClC family are:[16]

Cl− (out) ⇌ Cl− (in)

and

Cations (e.g., Ca2+) (out) ⇌ Cations (e.g., Ca2+) (in)

In humans edit

CaCCs that are known to occur in humans include:

See also edit

Notes edit

  1. ^ The anoctamins are only expressed in eukaryotes, with 10 members in vertebrates.[7] Although all anoctamins are calcium-activated, not all members of this family are ion channels like ANO1; some are phospholipid scramblases.[7] ANO1 was the first anoctamin discovered, with three research groups independently identifying it in 2008.[7] A single protein homologue to the vertebrate anoctamins has been found in fungi and yeast, Aspergillus fumigatus and Saccharomyces cerevisiae, respsectively.[7]

References edit

  1. ^ PDB: 5oyb​; Paulino C, Kalienkova V, Lam A, Neldner Y, Dutzler R (December 2017). "Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM" (PDF). Nature. 552 (7685): 421–425. Bibcode:2017Natur.552..421P. doi:10.1038/nature24652. PMID 29236691. S2CID 4457894.
  2. ^ Hartzell C, Putzier I, Arreola J (March 2005). "Calcium-activated chloride channels". Annual Review of Physiology. 67: 719–58. doi:10.1146/annurev.physiol.67.032003.154341. PMID 15709976. 
  3. ^ "CLCA1 chloride channel accessory 1 [Homo sapiens (human)]". Gene. National Center for Biotechnology Information. 13 January 2015.
  4. ^ a b Kunzelmann K, Kongsuphol P, Chootip K, Toledo C, Martins JR, Almaca J, Tian Y, Witzgall R, Ousingsawat J, Schreiber R (January 2011). "Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells". Biological Chemistry. 392 (1–2): 125–34. doi:10.1515/BC.2011.010. PMID 21194364. S2CID 24285022.
  5. ^ a b Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R (October 2009). "Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions". Cell Calcium. 46 (4): 233–41. doi:10.1016/j.ceca.2009.09.003. PMID 19783045.
  6. ^ a b Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM (February 2012). "Anoctamins and gastrointestinal smooth muscle excitability". Experimental Physiology. 97 (2): 200–6. doi:10.1113/expphysiol.2011.058248. PMC 3272164. PMID 22002868. 
  7. ^ a b c d e Brunner JD, Lim NK, Schenck S, Duerst A, Dutzler R (December 2014). "X-ray structure of a calcium-activated TMEM16 lipid scramblase". Nature. 516 (7530): 207–12. Bibcode:2014Natur.516..207B. doi:10.1038/nature13984. PMID 25383531. S2CID 1396768.
  8. ^ Evans SR, Thoreson WB, Beck CL (October 2004). "Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine". The Journal of Biological Chemistry. 279 (40): 41792–800. doi:10.1074/jbc.M408354200. PMC 1383427. PMID 15284223.
  9. ^ Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (October 2008). "TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity". Science. 322 (5901): 590–4. Bibcode:2008Sci...322..590C. doi:10.1126/science.1163518. PMID 18772398. S2CID 52870095.
  10. ^ Pang C, Yuan H, Ren S, Chen Y, An H, Zhan Y (1 January 2014). "TMEM16A/B associated CaCC: structural and functional insights". Protein and Peptide Letters. 21 (1): 94–9. doi:10.2174/09298665113206660098. PMID 24151904.
  11. ^ Kim KX, Fettiplace R (January 2013). "Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel-like proteins". The Journal of General Physiology. 141 (1): 141–8. doi:10.1085/jgp.201210913. PMC 3536526. PMID 23277480.
  12. ^ Kawashima Y, Géléoc GS, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu DK, Della Santina CC, Holt JR, Griffith AJ (December 2011). "Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes". The Journal of Clinical Investigation. 121 (12): 4796–809. doi:10.1172/JCI60405. PMC 3223072. PMID 22105175.
  13. ^ Smith CJ, Watson JD, Spencer WC, O'Brien T, Cha B, Albeg A, Treinin M, Miller DM (September 2010). "Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans". Developmental Biology. 345 (1): 18–33. doi:10.1016/j.ydbio.2010.05.502. PMC 2919608. PMID 20537990.
  14. ^ Chatzigeorgiou M, Bang S, Hwang SW, Schafer WR (February 2013). "tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans". Nature. 494 (7435): 95–99. Bibcode:2013Natur.494...95C. doi:10.1038/nature11845. PMC 4021456. PMID 23364694.
  15. ^ Liu J, Liu Y, Ren Y, Kang L, Zhang L (March 2014). "Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-κB signaling pathway". Molecular Medicine Reports. 9 (3): 1068–74. doi:10.3892/mmr.2014.1888. PMID 24401903.
  16. ^ "1.A.17 The Calcium-Dependent Chloride Channel (Ca-ClC) Family". TCDB. Retrieved 16 April 2016.
  17. ^ a b "Calcium activated chloride channel". IUPHAR/BPS Guide to Pharmacology. Retrieved 7 October 2015.

Further reading edit

  • "TCDB » SEARCH". www.tcdb.org. Retrieved 2016-04-16.
  • Milenkovic VM, Brockmann M, Stöhr H, Weber BH, Strauss O (October 2010). "Evolution and functional divergence of the anoctamin family of membrane proteins". BMC Evolutionary Biology. 10 (1): 319. Bibcode:2010BMCEE..10..319M. doi:10.1186/1471-2148-10-319. PMC 2974728. PMID 20964844.
  • Kunzelmann K, Cabrita I, Wanitchakool P, Ousingsawat J, Sirianant L, Benedetto R, Schreiber R (March 2016). "Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC". Pflügers Archiv. 468 (3): 475–90. doi:10.1007/s00424-015-1767-4. PMID 26700940. S2CID 14374080.
  • Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ (October 2008). "TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity". Science. 322 (5901): 590–4. Bibcode:2008Sci...322..590C. doi:10.1126/science.1163518. PMID 18772398. S2CID 52870095.
  • Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U (October 2008). "TMEM16A confers receptor-activated calcium-dependent chloride conductance". Nature. 455 (7217): 1210–5. Bibcode:2008Natur.455.1210Y. doi:10.1038/nature07313. PMID 18724360. S2CID 205214858.
  • Ferrera L, Caputo A, Ubby I, Bussani E, Zegarra-Moran O, Ravazzolo R, Pagani F, Galietta LJ (November 2009). "Regulation of TMEM16A chloride channel properties by alternative splicing". The Journal of Biological Chemistry. 284 (48): 33360–8. doi:10.1074/jbc.M109.046607. PMC 2785179. PMID 19819874.
  • Galietta LJ (December 2009). "The TMEM16 protein family: a new class of chloride channels?". Biophysical Journal. 97 (12): 3047–53. Bibcode:2009BpJ....97.3047G. doi:10.1016/j.bpj.2009.09.024. PMC 2793353. PMID 20006941.
  • Hwang SJ, Blair PJ, Britton FC, O'Driscoll KE, Hennig G, Bayguinov YR, Rock JR, Harfe BD, Sanders KM, Ward SM (October 2009). "Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles". The Journal of Physiology. 587 (Pt 20): 4887–904. doi:10.1113/jphysiol.2009.176198. PMC 2770154. PMID 19687122.
  • Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K (March 2010). "Expression and function of epithelial anoctamins". The Journal of Biological Chemistry. 285 (10): 7838–45. doi:10.1074/jbc.M109.065367. PMC 2844227. PMID 20056604.

As of this edit, this article uses content from "1.A.13 The Epithelial Chloride Channel (E-ClC) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. All relevant terms must be followed.

April 12, 2024
calcium, dependent, chloride, channel, calcium, dependent, chloride, channel, proteins, calcium, activated, chloride, channels, caccs, heterogeneous, groups, ligand, gated, channels, chloride, that, have, been, identified, many, epithelial, endothelial, cell, . The Calcium Dependent Chloride Channel Ca ClC proteins or calcium activated chloride channels CaCCs 2 are heterogeneous groups of ligand gated ion channels for chloride that have been identified in many epithelial and endothelial cell types as well as in smooth muscle cells They include proteins from several structurally different families chloride channel accessory CLCA 3 bestrophin BEST 4 5 and calcium dependent chloride channel anoctamin ANO or TMEM16 channels 4 5 6 7 ANO1 is highly expressed in human gastrointestinal interstitial cells of Cajal which are proteins which serve as intestinal pacemakers for peristalsis 6 In addition to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors 8 These eukaryotic proteins are required for normal electrolyte and fluid secretion olfactory perception and neuronal and smooth muscle excitability in animals 9 10 Members of the Ca CIC family are generally 600 to 1000 amino acyl residues aas in length and exhibit 7 to 10 transmembrane segments TMSs TMEM16Cartoon representation of a mTMEM16A chloride channel based on a cryoelectron microscopy reconstruction 1 IdentifiersSymbolApoctaminPfamPF04547InterProIPR032394TCDB1 A 17OPM superfamily369Membranome219Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Contents 1 Function 2 In humans 3 See also 4 Notes 5 References 6 Further readingFunction editTmc1 and Tmc2 TC s 1 A 17 4 6 and 1 A 17 4 1 respectively may play a role in hearing and are required for normal function of cochlear hair cells possibly as Ca2 channels or Ca2 channel subunits see also family TC 1 A 82 11 Mice lacking both channels lack hair cell mechanosensory potentials 12 There are 8 members of this family in humans 1 in Drosophila and 2 in C elegans One of the latter two is expressed in mechanoreceptors 13 Tmc1 is a sodium sensitive cation channel required for salt Na chemosensation in C elegans where it is required for salt evoked neuronal activity and behavioural avoidance of high concentrations of NaCl 14 TMEM16A is over expressed in several tumor types The role of TMEM16A in gliomas and the potential underlying mechanisms were analyzed by Liu et al 2014 Knockdown of TMEM16A suppressed cell proliferation migration and invasion 15 The reactions believed to be catalyzed by channels of the Ca ClC family are 16 Cl out Cl in andCations e g Ca2 out Cations e g Ca2 in In humans editCaCCs that are known to occur in humans include Accessories CLCA1 CLCA2 CLCA3 and CLCA4 Anoctamins note 1 ANO1 and ANO2 potentially others 17 Bestrophins BEST1 BEST2 BEST3 and BEST4 17 See also editVoltage gated ion channel Ion channelNotes edit The anoctamins are only expressed in eukaryotes with 10 members in vertebrates 7 Although all anoctamins are calcium activated not all members of this family are ion channels like ANO1 some are phospholipid scramblases 7 ANO1 was the first anoctamin discovered with three research groups independently identifying it in 2008 7 A single protein homologue to the vertebrate anoctamins has been found in fungi and yeast Aspergillus fumigatus and Saccharomyces cerevisiae respsectively 7 References edit PDB 5oyb Paulino C Kalienkova V Lam A Neldner Y Dutzler R December 2017 Activation mechanism of the calcium activated chloride channel TMEM16A revealed by cryo EM PDF Nature 552 7685 421 425 Bibcode 2017Natur 552 421P doi 10 1038 nature24652 PMID 29236691 S2CID 4457894 Hartzell C Putzier I Arreola J March 2005 Calcium activated chloride channels Annual Review of Physiology 67 719 58 doi 10 1146 annurev physiol 67 032003 154341 PMID 15709976 nbsp CLCA1 chloride channel accessory 1 Homo sapiens human Gene National Center for Biotechnology Information 13 January 2015 a b Kunzelmann K Kongsuphol P Chootip K Toledo C Martins JR Almaca J Tian Y Witzgall R Ousingsawat J Schreiber R January 2011 Role of the Ca2 activated Cl channels bestrophin and anoctamin in epithelial cells Biological Chemistry 392 1 2 125 34 doi 10 1515 BC 2011 010 PMID 21194364 S2CID 24285022 a b Kunzelmann K Kongsuphol P Aldehni F Tian Y Ousingsawat J Warth R Schreiber R October 2009 Bestrophin and TMEM16 Ca 2 activated Cl channels with different functions Cell Calcium 46 4 233 41 doi 10 1016 j ceca 2009 09 003 PMID 19783045 a b Sanders KM Zhu MH Britton F Koh SD Ward SM February 2012 Anoctamins and gastrointestinal smooth muscle excitability Experimental Physiology 97 2 200 6 doi 10 1113 expphysiol 2011 058248 PMC 3272164 PMID 22002868 nbsp a b c d e Brunner JD Lim NK Schenck S Duerst A Dutzler R December 2014 X ray structure of a calcium activated TMEM16 lipid scramblase Nature 516 7530 207 12 Bibcode 2014Natur 516 207B doi 10 1038 nature13984 PMID 25383531 S2CID 1396768 Evans SR Thoreson WB Beck CL October 2004 Molecular and functional analyses of two new calcium activated chloride channel family members from mouse eye and intestine The Journal of Biological Chemistry 279 40 41792 800 doi 10 1074 jbc M408354200 PMC 1383427 PMID 15284223 Caputo A Caci E Ferrera L Pedemonte N Barsanti C Sondo E Pfeffer U Ravazzolo R Zegarra Moran O Galietta LJ October 2008 TMEM16A a membrane protein associated with calcium dependent chloride channel activity Science 322 5901 590 4 Bibcode 2008Sci 322 590C doi 10 1126 science 1163518 PMID 18772398 S2CID 52870095 Pang C Yuan H Ren S Chen Y An H Zhan Y 1 January 2014 TMEM16A B associated CaCC structural and functional insights Protein and Peptide Letters 21 1 94 9 doi 10 2174 09298665113206660098 PMID 24151904 Kim KX Fettiplace R January 2013 Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel like proteins The Journal of General Physiology 141 1 141 8 doi 10 1085 jgp 201210913 PMC 3536526 PMID 23277480 Kawashima Y Geleoc GS Kurima K Labay V Lelli A Asai Y Makishima T Wu DK Della Santina CC Holt JR Griffith AJ December 2011 Mechanotransduction in mouse inner ear hair cells requires transmembrane channel like genes The Journal of Clinical Investigation 121 12 4796 809 doi 10 1172 JCI60405 PMC 3223072 PMID 22105175 Smith CJ Watson JD Spencer WC O Brien T Cha B Albeg A Treinin M Miller DM September 2010 Time lapse imaging and cell specific expression profiling reveal dynamic branching and molecular determinants of a multi dendritic nociceptor in C elegans Developmental Biology 345 1 18 33 doi 10 1016 j ydbio 2010 05 502 PMC 2919608 PMID 20537990 Chatzigeorgiou M Bang S Hwang SW Schafer WR February 2013 tmc 1 encodes a sodium sensitive channel required for salt chemosensation in C elegans Nature 494 7435 95 99 Bibcode 2013Natur 494 95C doi 10 1038 nature11845 PMC 4021456 PMID 23364694 Liu J Liu Y Ren Y Kang L Zhang L March 2014 Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor kB signaling pathway Molecular Medicine Reports 9 3 1068 74 doi 10 3892 mmr 2014 1888 PMID 24401903 1 A 17 The Calcium Dependent Chloride Channel Ca ClC Family TCDB Retrieved 16 April 2016 a b Calcium activated chloride channel IUPHAR BPS Guide to Pharmacology Retrieved 7 October 2015 Further reading edit TCDB SEARCH www tcdb org Retrieved 2016 04 16 Milenkovic VM Brockmann M Stohr H Weber BH Strauss O October 2010 Evolution and functional divergence of the anoctamin family of membrane proteins BMC Evolutionary Biology 10 1 319 Bibcode 2010BMCEE 10 319M doi 10 1186 1471 2148 10 319 PMC 2974728 PMID 20964844 Kunzelmann K Cabrita I Wanitchakool P Ousingsawat J Sirianant L Benedetto R Schreiber R March 2016 Modulating Ca signals a common theme for TMEM16 Ist2 and TMC Pflugers Archiv 468 3 475 90 doi 10 1007 s00424 015 1767 4 PMID 26700940 S2CID 14374080 Caputo A Caci E Ferrera L Pedemonte N Barsanti C Sondo E Pfeffer U Ravazzolo R Zegarra Moran O Galietta LJ October 2008 TMEM16A a membrane protein associated with calcium dependent chloride channel activity Science 322 5901 590 4 Bibcode 2008Sci 322 590C doi 10 1126 science 1163518 PMID 18772398 S2CID 52870095 Yang YD Cho H Koo JY Tak MH Cho Y Shim WS Park SP Lee J Lee B Kim BM Raouf R Shin YK Oh U October 2008 TMEM16A confers receptor activated calcium dependent chloride conductance Nature 455 7217 1210 5 Bibcode 2008Natur 455 1210Y doi 10 1038 nature07313 PMID 18724360 S2CID 205214858 Ferrera L Caputo A Ubby I Bussani E Zegarra Moran O Ravazzolo R Pagani F Galietta LJ November 2009 Regulation of TMEM16A chloride channel properties by alternative splicing The Journal of Biological Chemistry 284 48 33360 8 doi 10 1074 jbc M109 046607 PMC 2785179 PMID 19819874 Galietta LJ December 2009 The TMEM16 protein family a new class of chloride channels Biophysical Journal 97 12 3047 53 Bibcode 2009BpJ 97 3047G doi 10 1016 j bpj 2009 09 024 PMC 2793353 PMID 20006941 Hwang SJ Blair PJ Britton FC O Driscoll KE Hennig G Bayguinov YR Rock JR Harfe BD Sanders KM Ward SM October 2009 Expression of anoctamin 1 TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles The Journal of Physiology 587 Pt 20 4887 904 doi 10 1113 jphysiol 2009 176198 PMC 2770154 PMID 19687122 Schreiber R Uliyakina I Kongsuphol P Warth R Mirza M Martins JR Kunzelmann K March 2010 Expression and function of epithelial anoctamins The Journal of Biological Chemistry 285 10 7838 45 doi 10 1074 jbc M109 065367 PMC 2844227 PMID 20056604 As of this edit this article uses content from 1 A 13 The Epithelial Chloride Channel E ClC Family which is licensed in a way that permits reuse under the Creative Commons Attribution ShareAlike 3 0 Unported License but not under the GFDL All relevant terms must be followed Retrieved from https en wikipedia org w index php title Calcium dependent chloride channel amp oldid 1187412508, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.