The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).[4]
^Hristov M, Zernecke A, Bidzhekov K, et al. (March 2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812.
^Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem. 266 (9): 5785–9. doi:10.1016/S0021-9258(19)67665-9. PMID 1826003.
^Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA. 80 (3): 765–9. Bibcode:1983PNAS...80..765C. doi:10.1073/pnas.80.3.765. PMC393460. PMID 6572368.
^Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry. 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.
Further readingedit
Begg GS, Pepper DS, Chesterman CN, Morgan FJ (1978). "Complete covalent structure of human beta-thromboglobulin". Biochemistry. 17 (9): 1739–44. doi:10.1021/bi00602a024. PMID 77677.
Kaplan KL, Broekman MJ, Chernoff A, et al. (1979). "Platelet alpha-granule proteins: studies on release and subcellular localization". Blood. 53 (4): 604–18. doi:10.1182/blood.V53.4.604.604. PMID 426909.
Tunnacliffe A, Majumdar S, Yan B, Poncz M (1992). "Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4". Blood. 79 (11): 2896–900. doi:10.1182/blood.V79.11.2896.bloodjournal79112896. PMID 1316786.
Cohen AB, Stevens MD, Miller EJ, et al. (1992). "Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets". Am. J. Physiol. 263 (2 Pt 1): L249–56. doi:10.1152/ajplung.1992.263.2.L249. PMID 1387511.
Morris SW, Nelson N, Valentine MB, et al. (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics. 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.
Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J. Biol. Chem. 266 (9): 5785–9. doi:10.1016/S0021-9258(19)67665-9. PMID 1826003.
Wenger RH, Hameister H, Clemetson KJ (1991). "Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily". Hum. Genet. 87 (3): 367–8. doi:10.1007/BF00200921. PMID 1830861. S2CID 19420329.
Hjemdahl P, Perneby C, Theodorsson E, et al. (1992). "A new assay for beta-thromboglobulin in urine". Thromb. Res. 64 (1): 33–43. doi:10.1016/0049-3848(91)90203-9. PMID 1837963.
Brandt E, Van Damme J, Flad HD (1991). "Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III". Cytokine. 3 (4): 311–21. doi:10.1016/1043-4666(91)90499-4. PMID 1873479.
Clark-Lewis I, Moser B, Walz A, et al. (1991). "Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide". Biochemistry. 30 (12): 3128–35. doi:10.1021/bi00226a021. PMID 2007144.
Walz A, Baggiolini M (1990). "Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases". J. Exp. Med. 171 (2): 449–54. doi:10.1084/jem.171.2.449. PMC2187709. PMID 2406364.
Holt JC, Harris ME, Holt AM, et al. (1986). "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin". Biochemistry. 25 (8): 1988–96. doi:10.1021/bi00356a023. PMID 2423119.
Walz A, Baggiolini M (1989). "A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils". Biochem. Biophys. Res. Commun. 159 (3): 969–75. doi:10.1016/0006-291X(89)92203-1. PMID 2522778.
Wenger RH, Wicki AN, Walz A, et al. (1989). "Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library". Blood. 73 (6): 1498–503. doi:10.1182/blood.V73.6.1498.1498. PMID 2713489.
Castor CW, Walz DA, Ragsdale CG, et al. (1989). "Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets". Biochem. Biophys. Res. Commun. 163 (2): 1071–8. doi:10.1016/0006-291X(89)92330-9. PMID 2783111.
Holt JC, Rabellino EM, Gewirtz AM, et al. (1988). "Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes". Exp. Hematol. 16 (4): 302–6. PMID 2966071.
Castor CW, Furlong AM, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry. 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.
McLaren KM, Pepper DS (1983). "Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets". J. Clin. Pathol. 35 (11): 1227–31. doi:10.1136/jcp.35.11.1227. PMC497932. PMID 6183294.
Castor CW, Miller JW, Walz DA (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc. Natl. Acad. Sci. U.S.A. 80 (3): 765–9. Bibcode:1983PNAS...80..765C. doi:10.1073/pnas.80.3.765. PMC393460. PMID 6572368.
Malkowski MG, Wu JY, Lazar JB, et al. (1995). "The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution". J. Biol. Chem. 270 (13): 7077–87. doi:10.1074/jbc.270.13.7077. PMID 7706245.
External linksedit
Human PPBP genome location and PPBP gene details page in the UCSC Genome Browser.
This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.
cxcl7, chemokine, motif, ligand, human, gene, ppbpavailable, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes1tvx, 1f9p, 1napidentifiersaliasesppbp, beta, ctap, ctap3, ctapiii, ldgf, mdgf, scyb7, tgb1, thbgb, thbgb1, platelet, basic, proteinexternal,. Chemokine C X C motif ligand 7 CXCL7 is a human gene 3 PPBPAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1TVX 1F9P 1NAPIdentifiersAliasesPPBP B TG1 Beta TG CTAP III CTAP3 CTAPIII CXCL7 LA PF4 LDGF MDGF NAP 2 PBP SCYB7 TC1 TC2 TGB TGB1 THBGB THBGB1 pro platelet basic proteinExternal IDsOMIM 121010 HomoloGene 136759 GeneCards PPBPGene location Human Chr Chromosome 4 human 1 Band4q13 3Start73 986 439 bp 1 End73 988 190 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inmonocytespongy bonebloodbone marrow cellsperiodontal fiberspleenright lungbiceps brachiiupper lobe of left lunglower lobe of lungn aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functiongrowth factor activity cytokine activity glucose transmembrane transporter activity CXCR chemokine receptor binding chemokine activity protein bindingCellular componentplatelet alpha granule lumen extracellular region extracellular space tertiary granule lumen platelet alpha granuleBiological processresponse to lipopolysaccharide regulation of cell population proliferation chemotaxis positive regulation of cell division platelet degranulation defense response to bacterium inflammatory response immune response chemokine mediated signaling pathway defense response positive regulation of neutrophil chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity neutrophil degranulation cell chemotaxis G protein coupled receptor signaling pathway glucose transmembrane transport neutrophil chemotaxis leukocyte chemotaxis cellular response to lipopolysaccharideSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5473n aEnsemblENSG00000163736n aUniProtP02775n aRefSeq mRNA NM 002704n aRefSeq protein NP 002695n aLocation UCSC Chr 4 73 99 73 99 Mbn aPubMed search 2 n aWikidataView Edit HumanThe encoded protein Chemokine C X C motif ligand is a small cytokine belonging to the CXC chemokine family It is an isoform of Beta Thromboglobulin or Pro Platelet basic protein PPBP 4 It is a protein that is released in large amounts from platelets following their activation 5 It stimulates various processes including mitogenesis synthesis of extracellular matrix glucose metabolism and synthesis of plasminogen activator 6 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000163736 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene PPBP pro platelet basic protein chemokine C X C motif ligand 7 Hristov M Zernecke A Bidzhekov K et al March 2007 Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury Circ Res 100 4 590 7 doi 10 1161 01 RES 0000259043 42571 68 PMID 17272812 Majumdar S Gonder D Koutsis B Poncz M 1991 Characterization of the human beta thromboglobulin gene Comparison with the gene for platelet factor 4 J Biol Chem 266 9 5785 9 doi 10 1016 S0021 9258 19 67665 9 PMID 1826003 Castor C Miller J Walz D 1983 Structural and biological characteristics of connective tissue activating peptide CTAP III a major human platelet derived growth factor Proc Natl Acad Sci USA 80 3 765 9 Bibcode 1983PNAS 80 765C doi 10 1073 pnas 80 3 765 PMC 393460 PMID 6572368 Castor C Furlong A Carter Su C 1985 Connective tissue activation stimulation of glucose transport by connective tissue activating peptide III Biochemistry 24 7 1762 7 doi 10 1021 bi00328a029 PMID 4005226 Further reading editBegg GS Pepper DS Chesterman CN Morgan FJ 1978 Complete covalent structure of human beta thromboglobulin Biochemistry 17 9 1739 44 doi 10 1021 bi00602a024 PMID 77677 Kaplan KL Broekman MJ Chernoff A et al 1979 Platelet alpha granule proteins studies on release and subcellular localization Blood 53 4 604 18 doi 10 1182 blood V53 4 604 604 PMID 426909 Tunnacliffe A Majumdar S Yan B Poncz M 1992 Genes for beta thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4 Blood 79 11 2896 900 doi 10 1182 blood V79 11 2896 bloodjournal79112896 PMID 1316786 Cohen AB Stevens MD Miller EJ et al 1992 Generation of the neutrophil activating peptide 2 by cathepsin G and cathepsin G treated human platelets Am J Physiol 263 2 Pt 1 L249 56 doi 10 1152 ajplung 1992 263 2 L249 PMID 1387511 Morris SW Nelson N Valentine MB et al 1992 Assignment of the genes encoding human interleukin 8 receptor types 1 and 2 and an interleukin 8 receptor pseudogene to chromosome 2q35 Genomics 14 3 685 91 doi 10 1016 S0888 7543 05 80169 7 PMID 1427896 Majumdar S Gonder D Koutsis B Poncz M 1991 Characterization of the human beta thromboglobulin gene Comparison with the gene for platelet factor 4 J Biol Chem 266 9 5785 9 doi 10 1016 S0021 9258 19 67665 9 PMID 1826003 Wenger RH Hameister H Clemetson KJ 1991 Human platelet basic protein connective tissue activating peptide III maps in a gene cluster on chromosome 4q12 q13 along with other genes of the beta thromboglobulin superfamily Hum Genet 87 3 367 8 doi 10 1007 BF00200921 PMID 1830861 S2CID 19420329 Hjemdahl P Perneby C Theodorsson E et al 1992 A new assay for beta thromboglobulin in urine Thromb Res 64 1 33 43 doi 10 1016 0049 3848 91 90203 9 PMID 1837963 Brandt E Van Damme J Flad HD 1991 Neutrophils can generate their activator neutrophil activating peptide 2 by proteolytic cleavage of platelet derived connective tissue activating peptide III Cytokine 3 4 311 21 doi 10 1016 1043 4666 91 90499 4 PMID 1873479 Clark Lewis I Moser B Walz A et al 1991 Chemical synthesis purification and characterization of two inflammatory proteins neutrophil activating peptide 1 interleukin 8 and neutrophil activating peptide Biochemistry 30 12 3128 35 doi 10 1021 bi00226a021 PMID 2007144 Walz A Baggiolini M 1990 Generation of the neutrophil activating peptide NAP 2 from platelet basic protein or connective tissue activating peptide III through monocyte proteases J Exp Med 171 2 449 54 doi 10 1084 jem 171 2 449 PMC 2187709 PMID 2406364 Holt JC Harris ME Holt AM et al 1986 Characterization of human platelet basic protein a precursor form of low affinity platelet factor 4 and beta thromboglobulin Biochemistry 25 8 1988 96 doi 10 1021 bi00356a023 PMID 2423119 Walz A Baggiolini M 1989 A novel cleavage product of beta thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils Biochem Biophys Res Commun 159 3 969 75 doi 10 1016 0006 291X 89 92203 1 PMID 2522778 Wenger RH Wicki AN Walz A et al 1989 Cloning of cDNA coding for connective tissue activating peptide III from a human platelet derived lambda gt11 expression library Blood 73 6 1498 503 doi 10 1182 blood V73 6 1498 1498 PMID 2713489 Castor CW Walz DA Ragsdale CG et al 1989 Connective tissue activation XXXIII Biologically active cleavage products of CTAP III from human platelets Biochem Biophys Res Commun 163 2 1071 8 doi 10 1016 0006 291X 89 92330 9 PMID 2783111 Holt JC Rabellino EM Gewirtz AM et al 1988 Occurrence of platelet basic protein a precursor of low affinity platelet factor 4 and beta thromboglobulin in human platelets and megakaryocytes Exp Hematol 16 4 302 6 PMID 2966071 Castor CW Furlong AM Carter Su C 1985 Connective tissue activation stimulation of glucose transport by connective tissue activating peptide III Biochemistry 24 7 1762 7 doi 10 1021 bi00328a029 PMID 4005226 McLaren KM Pepper DS 1983 Immunological localisation of beta thromboglobulin and platelet factor 4 in human megakaryocytes and platelets J Clin Pathol 35 11 1227 31 doi 10 1136 jcp 35 11 1227 PMC 497932 PMID 6183294 Castor CW Miller JW Walz DA 1983 Structural and biological characteristics of connective tissue activating peptide CTAP III a major human platelet derived growth factor Proc Natl Acad Sci U S A 80 3 765 9 Bibcode 1983PNAS 80 765C doi 10 1073 pnas 80 3 765 PMC 393460 PMID 6572368 Malkowski MG Wu JY Lazar JB et al 1995 The crystal structure of recombinant human neutrophil activating peptide 2 M6L at 1 9 A resolution J Biol Chem 270 13 7077 87 doi 10 1074 jbc 270 13 7077 PMID 7706245 External links editHuman PPBP genome location and PPBP gene details page in the UCSC Genome Browser nbsp This article on a gene on human chromosome 4 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CXCL7 amp oldid 1118643892, wikipedia, wiki, book, books, library,
