2-hydroxymuconate tautomerase (EC 5.3.2.6, 4-oxalocrotonate tautomerase, 4-oxalocrotonate isomerase, cnbG (gene), praC (gene), xylH (gene)) is an enzyme with systematic name(2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols.
Referencesedit
^Whitman CP, Aird BA, Gillespie WR, Stolowich NJ (1991). "Chemical and enzymatic ketonization of 2-hydroxymuconate, a conjugated enol". J. Am. Chem. Soc. 113 (8): 3154–3162. doi:10.1021/ja00008a052.
^Whitman CP, Hajipour G, Watson RJ, Johnson WH, Bembenek ME, Stolowich NJ (1992). "Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase". J. Am. Chem. Soc. 114 (26): 10104–10110. doi:10.1021/ja00052a002.
^Subramanya HS, Roper DI, Dauter Z, Dodson EJ, Davies GJ, Wilson KS, Wigley DB (January 1996). "Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases". Biochemistry. 35 (3): 792–802. doi:10.1021/bi951732k. PMID 8547259.
^Stivers JT, Abeygunawardana C, Mildvan AS, Hajipour G, Whitman CP, Chen LH (January 1996). "Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies". Biochemistry. 35 (3): 803–13. doi:10.1021/bi951077g. PMID 8547260.
^Wang SC, Johnson WH, Czerwinski RM, Stamps SL, Whitman CP (October 2007). "Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions". Biochemistry. 46 (42): 11919–29. doi:10.1021/bi701231a. PMC2531070. PMID 17902707.
^Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E (November 2009). "Uncovering the protocatechuate 2,3-cleavage pathway genes". Journal of Bacteriology. 191 (21): 6758–68. doi:10.1128/JB.00840-09. PMC2795304. PMID 19717587.
External linksedit
2-hydroxymuconate+tautomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
hydroxymuconate, tautomerase, oxalocrotonate, tautomerase, oxalocrotonate, isomerase, cnbg, gene, prac, gene, xylh, gene, enzyme, with, systematic, name, hydroxyhexa, dienedioate, keto, enol, isomerase, this, enzyme, catalyses, following, chemical, reactionide. 2 hydroxymuconate tautomerase EC 5 3 2 6 4 oxalocrotonate tautomerase 4 oxalocrotonate isomerase cnbG gene praC gene xylH gene is an enzyme with systematic name 2Z 4E 2 hydroxyhexa 2 4 dienedioate keto enol isomerase 1 2 3 4 5 6 This enzyme catalyses the following chemical reaction2 hydroxymuconate tautomeraseIdentifiersEC no 5 3 2 6DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins 2Z 4E 2 hydroxyhexa 2 4 dienedioate displaystyle rightleftharpoons 3E 2 oxohex 3 enedioate Involved in the meta cleavage pathway for the degradation of phenols modified phenols and catechols References edit Whitman CP Aird BA Gillespie WR Stolowich NJ 1991 Chemical and enzymatic ketonization of 2 hydroxymuconate a conjugated enol J Am Chem Soc 113 8 3154 3162 doi 10 1021 ja00008a052 Whitman CP Hajipour G Watson RJ Johnson WH Bembenek ME Stolowich NJ 1992 Stereospecific ketonization of 2 hydroxymuconate by 4 oxalocrotonate tautomerase and 5 carboxymethyl 2 hydroxymuconate isomerase J Am Chem Soc 114 26 10104 10110 doi 10 1021 ja00052a002 Subramanya HS Roper DI Dauter Z Dodson EJ Davies GJ Wilson KS Wigley DB January 1996 Enzymatic ketonization of 2 hydroxymuconate specificity and mechanism investigated by the crystal structures of two isomerases Biochemistry 35 3 792 802 doi 10 1021 bi951732k PMID 8547259 Stivers JT Abeygunawardana C Mildvan AS Hajipour G Whitman CP Chen LH January 1996 Catalytic role of the amino terminal proline in 4 oxalocrotonate tautomerase affinity labeling and heteronuclear NMR studies Biochemistry 35 3 803 13 doi 10 1021 bi951077g PMID 8547260 Wang SC Johnson WH Czerwinski RM Stamps SL Whitman CP October 2007 Kinetic and stereochemical analysis of YwhB a 4 oxalocrotonate tautomerase homologue in Bacillus subtilis mechanistic implications for the YwhB and 4 oxalocrotonate tautomerase catalyzed reactions Biochemistry 46 42 11919 29 doi 10 1021 bi701231a PMC 2531070 PMID 17902707 Kasai D Fujinami T Abe T Mase K Katayama Y Fukuda M Masai E November 2009 Uncovering the protocatechuate 2 3 cleavage pathway genes Journal of Bacteriology 191 21 6758 68 doi 10 1128 JB 00840 09 PMC 2795304 PMID 19717587 External links edit2 hydroxymuconate tautomerase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title 2 hydroxymuconate tautomerase amp oldid 1172334919, wikipedia, wiki, book, books, library,
