This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.[4] The gene is thought to be related to high-altitude adaptation in humans.[5]
References
^ abcGRCh38: Ensembl release 89: ENSG00000172288 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
^Zhang YB, Li X, Zhang F, Wang DM, Yu J (2012). "A preliminary study of copy number variation in Tibetans". PLOS ONE. 7 (7): e41768. Bibcode:2012PLoSO...741768Z. doi:10.1371/journal.pone.0041768. PMC3402393. PMID 22844521.
External links
Human CDY1 genome location and CDY1 gene details page in the UCSC Genome Browser.
Further reading
Jones DO, Cowell IG, Singh PB (2000). "Mammalian chromodomain proteins: their role in genome organisation and expression". BioEssays. 22 (2): 124–37. CiteSeerX10.1.1.575.6410. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032.
Yen PH (1999). "A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males". Genomics. 54 (1): 5–12. doi:10.1006/geno.1998.5526. PMID 9806824.
Lahn BT, Page DC (1999). "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome". Nat. Genet. 21 (4): 429–33. doi:10.1038/7771. PMID 10192397. S2CID 8345990.
Saut N, Terriou P, Navarro A, et al. (2000). "The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility". Mol. Hum. Reprod. 6 (9): 789–93. doi:10.1093/molehr/6.9.789. PMID 10956550.
Kleiman SE, Lagziel A, Yogev L, et al. (2001). "Expression of CDY1 may identify complete spermatogenesis". Fertil. Steril. 75 (1): 166–73. doi:10.1016/S0015-0282(00)01639-3. PMID 11163833.
Ferlin A, Moro E, Rossi A, Foresta C (2001). "CDY1 analysis in infertile patients with DAZ deletions". J. Endocrinol. Invest. 24 (2): RC4–6. doi:10.1007/bf03343814. PMID 11263480. S2CID 22500357.
Lahn BT, Tang ZL, Zhou J, et al. (2002). "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8707–12. Bibcode:2002PNAS...99.8707L. doi:10.1073/pnas.082248899. PMC124363. PMID 12072557.
Kostova E, Röttger S, Schempp W, Gromoll J (2003). "Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family". Mol. Hum. Reprod. 8 (8): 702–9. doi:10.1093/molehr/8.8.702. PMID 12149400.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
Dorus S, Gilbert SL, Forster ML, et al. (2003). "The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence". Hum. Mol. Genet. 12 (14): 1643–50. doi:10.1093/hmg/ddg185. PMID 12837688.
Kleiman SE, Yogev L, Hauser R, et al. (2003). "Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis". Hum. Genet. 113 (6): 486–92. doi:10.1007/s00439-003-0990-9. PMID 14569460. S2CID 43221279.
This protein-related article is a stub. You can help Wikipedia by expanding it.
cdy1, testis, specific, chromodomain, protein, protein, that, humans, encoded, gene, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes2fbmidentifiersaliases, chromodomain, protein, linked, chromodomain, linked, 1external, idsomim, 400016, h. Testis specific chromodomain protein Y 1 is a protein that in humans is encoded by the CDY1 gene 3 4 CDY1Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes2FBMIdentifiersAliasesCDY1 CDY CDY1A chromodomain protein Y linked 1 chromodomain Y linked 1External IDsOMIM 400016 HomoloGene 36165 GeneCards CDY1Gene location Human Chr Y chromosome human 1 BandYq11 23Start25 622 162 bp 1 End25 624 902 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed intesticlemulticellular organismn aMore reference expression dataBioGPSn aGene ontologyMolecular functionhistone acetyltransferase activity methylated histone binding transferase activity acyltransferase activity catalytic activity transcription corepressor activityCellular componentnucleusBiological processhistone acetylation metabolism spermatogenesis negative regulation of nucleic acid templated transcriptionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez9085n aEnsemblENSG00000172288n aUniProtQ9Y6F8n aRefSeq mRNA NM 004680NM 170723n aRefSeq protein NP 004671NP 733841n aLocation UCSC Chr Y 25 62 25 62 Mbn aPubMed search 2 n aWikidataView Edit HumanThis gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain Chromodomain proteins are components of heterochromatin like complexes and can act as gene repressors This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA packaging protein The human chromosome Y has two identical copies of this gene within a palindromic region this record represents the more telomeric copy Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes Two protein isoforms are encoded by transcript variants of this gene Additional transcript variants have been described but their full length nature has not been determined 4 The gene is thought to be related to high altitude adaptation in humans 5 References Edit a b c GRCh38 Ensembl release 89 ENSG00000172288 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Lahn BT Page DC Nov 1997 Functional coherence of the human Y chromosome Science 278 5338 675 80 Bibcode 1997Sci 278 675L doi 10 1126 science 278 5338 675 PMID 9381176 a b Entrez Gene CDY1 chromodomain protein Y linked 1 Zhang YB Li X Zhang F Wang DM Yu J 2012 A preliminary study of copy number variation in Tibetans PLOS ONE 7 7 e41768 Bibcode 2012PLoSO 741768Z doi 10 1371 journal pone 0041768 PMC 3402393 PMID 22844521 External links EditHuman CDY1 genome location and CDY1 gene details page in the UCSC Genome Browser Further reading EditJones DO Cowell IG Singh PB 2000 Mammalian chromodomain proteins their role in genome organisation and expression BioEssays 22 2 124 37 CiteSeerX 10 1 1 575 6410 doi 10 1002 SICI 1521 1878 200002 22 2 lt 124 AID BIES4 gt 3 0 CO 2 E PMID 10655032 Yen PH 1999 A long range restriction map of deletion interval 6 of the human Y chromosome a region frequently deleted in azoospermic males Genomics 54 1 5 12 doi 10 1006 geno 1998 5526 PMID 9806824 Lahn BT Page DC 1999 Retroposition of autosomal mRNA yielded testis specific gene family on human Y chromosome Nat Genet 21 4 429 33 doi 10 1038 7771 PMID 10192397 S2CID 8345990 Saut N Terriou P Navarro A et al 2000 The human Y chromosome genes BPY2 CDY1 and DAZ are not essential for sustained fertility Mol Hum Reprod 6 9 789 93 doi 10 1093 molehr 6 9 789 PMID 10956550 Kleiman SE Lagziel A Yogev L et al 2001 Expression of CDY1 may identify complete spermatogenesis Fertil Steril 75 1 166 73 doi 10 1016 S0015 0282 00 01639 3 PMID 11163833 Ferlin A Moro E Rossi A Foresta C 2001 CDY1 analysis in infertile patients with DAZ deletions J Endocrinol Invest 24 2 RC4 6 doi 10 1007 bf03343814 PMID 11263480 S2CID 22500357 Lahn BT Tang ZL Zhou J et al 2002 Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis Proc Natl Acad Sci U S A 99 13 8707 12 Bibcode 2002PNAS 99 8707L doi 10 1073 pnas 082248899 PMC 124363 PMID 12072557 Kostova E Rottger S Schempp W Gromoll J 2003 Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY an orthologue of the human CDY gene family Mol Hum Reprod 8 8 702 9 doi 10 1093 molehr 8 8 702 PMID 12149400 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Skaletsky H Kuroda Kawaguchi T Minx PJ et al 2003 The male specific region of the human Y chromosome is a mosaic of discrete sequence classes Nature 423 6942 825 37 Bibcode 2003Natur 423 825S doi 10 1038 nature01722 PMID 12815422 Dorus S Gilbert SL Forster ML et al 2003 The CDY related gene family coordinated evolution in copy number expression profile and protein sequence Hum Mol Genet 12 14 1643 50 doi 10 1093 hmg ddg185 PMID 12837688 Kleiman SE Yogev L Hauser R et al 2003 Members of the CDY family have different expression patterns CDY1 transcripts have the best correlation with complete spermatogenesis Hum Genet 113 6 486 92 doi 10 1007 s00439 003 0990 9 PMID 14569460 S2CID 43221279 This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CDY1 amp oldid 1136147598, wikipedia, wiki, book, books, library,
