arachidonoyl-CoA + CDP-acylglycerol CoA + CDP-diacylglycerol
When discovered in 1979, the two substrates of this enzyme were believed to be arachidonoyl-CoA and CDP-acylglycerol, whereas its two products were CoA and CDP-diacylglycerol.[1]
Such enzyme were describes as transferases, specifically acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class was arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase. Other names also found are CDP-acylglycerol O-arachidonyltransferase, and arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase. Such enzyme was presumably participating in glycerophospholipid metabolism.
However, no CDP-acylglycerol O-arachidonoyltransferase has been characterized, the reaction demonstrated in 1979 by Thompson and MacDonald was not reproducible. In 1983, W. Thomson retracted his discovery explaining possible contamination of their batch of liponucleotides.[2]
Referencesedit
^Thompson, W.; MacDonald, G. (1979-05-10). "Isolation of a specific arachidonoyl coenzyme A: cytidine diphosphate monoacylglycerol acyltransferase". The Journal of Biological Chemistry. 254 (9): 3311–3314. ISSN 0021-9258. PMID 429352.
^Thompson, W.; Zuk, R. T. (1983-08-25). "Acylation of CDP-monoacylglycerol cannot be confirmed". The Journal of Biological Chemistry. 258 (16): 9623. ISSN 0021-9258. PMID 6885763.
Thompson W, MacDonald G (1979). "Isolation of a specific arachidonoyl coenzyme A: cytidine diphosphate monoacylglycerol acyltransferase". J. Biol. Chem. 254 (9): 3311–4. PMID 429352.
acylglycerol, arachidonoyltransferase, enzymology, enzyme, construed, catalyze, chemical, reactionidentifiersec, 70cas, 70771, 1databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwaypriamprofilepdb, structure. In enzymology a CDP acylglycerol O arachidonoyltransferase EC 2 3 1 70 was an enzyme construed to catalyze the chemical reactionCDP acylglycerol O arachidonoyltransferaseIdentifiersEC no 2 3 1 70CAS no 70771 22 1DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins arachidonoyl CoA CDP acylglycerol displaystyle rightleftharpoons CoA CDP diacylglycerolWhen discovered in 1979 the two substrates of this enzyme were believed to be arachidonoyl CoA and CDP acylglycerol whereas its two products were CoA and CDP diacylglycerol 1 Such enzyme were describes as transferases specifically acyltransferases transferring groups other than aminoacyl groups The systematic name of this enzyme class was arachidonoyl CoA CDP acylglycerol O arachidonoyltransferase Other names also found are CDP acylglycerol O arachidonyltransferase and arachidonyl CoA CDP acylglycerol O arachidonyltransferase Such enzyme was presumably participating in glycerophospholipid metabolism However no CDP acylglycerol O arachidonoyltransferase has been characterized the reaction demonstrated in 1979 by Thompson and MacDonald was not reproducible In 1983 W Thomson retracted his discovery explaining possible contamination of their batch of liponucleotides 2 References edit Thompson W MacDonald G 1979 05 10 Isolation of a specific arachidonoyl coenzyme A cytidine diphosphate monoacylglycerol acyltransferase The Journal of Biological Chemistry 254 9 3311 3314 ISSN 0021 9258 PMID 429352 Thompson W Zuk R T 1983 08 25 Acylation of CDP monoacylglycerol cannot be confirmed The Journal of Biological Chemistry 258 16 9623 ISSN 0021 9258 PMID 6885763 Thompson W MacDonald G 1979 Isolation of a specific arachidonoyl coenzyme A cytidine diphosphate monoacylglycerol acyltransferase J Biol Chem 254 9 3311 4 PMID 429352 Portal nbsp Biology This EC 2 3 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title CDP acylglycerol O arachidonoyltransferase amp oldid 1172384221, wikipedia, wiki, book, books, library,
