Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.[3]
In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.[4][5] Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.[6] Also, it plays a significant role in the inhibition of differentiation [7] and apoptosis [8] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.[9] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).[10][11]
^Beauchemin N, Arabzadeh A (December 2013). "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews. 32 (3–4): 643–671. doi:10.1007/s10555-013-9444-6. PMID 23903773. S2CID 10344352.
^Zhang X, Han X, Zuo P, Zhang X, Xu H (September 2020). "CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration". The Journal of International Medical Research. 48 (9): 300060520959478. doi:10.1177/0300060520959478. PMC7536504. PMID 32993395.
^Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP (April 1989). "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell. 57 (2): 327–334. doi:10.1016/0092-8674(89)90970-7. PMID 2702691. S2CID 30740594.
^Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia. 4 (2): 151–163. doi:10.1038/sj.neo.7900201. PMC1550325. PMID 11896570.
^Ordoñez C, Screaton RA, Ilantzis C, Stanners CP (July 2000). "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research. 60 (13): 3419–3424. PMID 10910050.
^Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. (2021-01-01). "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers. 32 (1): 85–98. doi:10.3233/CBM-203187. PMID 34092615. S2CID 235359543.
^LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, et al. (2021-05-20). "Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701)". Journal of Clinical Oncology. 39 (15_suppl): e21030. doi:10.1200/JCO.2021.39.15_suppl.e21030. ISSN 0732-183X. S2CID 236398737.
^Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS (2023-02-27). "Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates". Frontiers in Oncology. 13: 1124039. doi:10.3389/fonc.2023.1124039. PMC10010383. PMID 36923424.
Further readingedit
Willcocks TC, Craig IW (November 1990). "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region". Genomics. 8 (3): 492–500. doi:10.1016/0888-7543(90)90036-T. PMID 2286372.
Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". Tumour Biology. 11 (1–2): 59–63. doi:10.1159/000217643. PMID 2309067.
Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, et al. (June 1990). "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Molecular and Cellular Biology. 10 (6): 2738–2748. doi:10.1128/MCB.10.6.2738. PMC360634. PMID 2342461.
Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, et al. (August 1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5350–5354. Bibcode:1987PNAS...84.5350K. doi:10.1073/pnas.84.15.5350. PMC298853. PMID 2955415.
Zimmermann W, Ortlieb B, Friedrich R, von Kleist S (May 1987). "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2960–2964. Bibcode:1987PNAS...84.2960Z. doi:10.1073/pnas.84.9.2960. PMC304780. PMID 3033671.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (July 1988). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics. 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
Zimmermann W, Weber B, Ortlieb B, Rudert F, Schempp W, Fiebig HH, et al. (May 1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Research. 48 (9): 2550–2554. PMID 3356015.
Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP (September 1987). "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Molecular and Cellular Biology. 7 (9): 3221–3230. doi:10.1128/MCB.7.9.3221. PMC367958. PMID 3670312.
Oikawa S, Nakazato H, Kosaki G (January 1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochemical and Biophysical Research Communications. 142 (2): 511–518. doi:10.1016/0006-291X(87)90304-4. PMID 3814146.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hart SP, Ross JA, Ross K, Haslett C, Dransfield I (May 2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death and Differentiation. 7 (5): 493–503. doi:10.1038/sj.cdd.4400680. PMID 10800083.
Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL (June 2000). "Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells". Infection and Immunity. 68 (6): 3554–3563. doi:10.1128/IAI.68.6.3554-3563.2000. PMC97642. PMID 10816511.
Boehm MK, Perkins SJ (June 2000). "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Letters. 475 (1): 11–16. doi:10.1016/S0014-5793(00)01612-4. PMID 10854848. S2CID 5765612.
Screaton RA, DeMarte L, Dráber P, Stanners CP (August 2000). "The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor". The Journal of Cell Biology. 150 (3): 613–626. doi:10.1083/jcb.150.3.613. PMC2175204. PMID 10931872.
Bajenova OV, Zimmer R, Stolper E, Salisbury-Rowswell J, Nanji A, Thomas P (August 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". The Journal of Biological Chemistry. 276 (33): 31067–31073. doi:10.1074/jbc.M104093200. PMID 11406629.
Wirth T, Soeth E, Czubayko F, Juhl H (2002). "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clinical & Experimental Metastasis. 19 (2): 155–160. doi:10.1023/A:1014566127493. PMID 11964079. S2CID 3138022.
Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C (October 2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". International Journal of Cancer. 101 (6): 545–548. doi:10.1002/ijc.90009. PMID 12237895. S2CID 7030523.
Hampton R, Walker M, Marshall J, Juhl H (November 2002). "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene. 21 (51): 7817–7823. doi:10.1038/sj.onc.1205906. PMID 12420218.
Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
ceacam5, carcinoembryonic, antigen, related, cell, adhesion, molecule, also, known, cd66e, cluster, differentiation, member, carcinoembryonic, antigen, gene, family, available, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes1e07, 2qsq, 2qst, 2veride. Carcinoembryonic antigen related cell adhesion molecule 5 CEACAM5 also known as CD66e Cluster of Differentiation 66e is a member of the carcinoembryonic antigen CEA gene family 3 CEACAM5Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1E07 2QSQ 2QST 2VERIdentifiersAliasesCEACAM5 CD66e CEA carcinoembryonic antigen related cell adhesion molecule 5 CEA cell adhesion molecule 5External IDsOMIM 114890 HomoloGene 128801 GeneCards CEACAM5Gene location Human Chr Chromosome 19 human 1 Band19q13 2Start41 708 585 bp 1 End41 730 433 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inrectumappendixcavity of mouthpalpebral conjunctivatracheacervix epitheliumbody of tonguepancreatic ductal cellgumsjejunal mucosan aMore reference expression dataBioGPSn aGene ontologyMolecular functionGPI anchor binding protein homodimerization activity identical protein bindingCellular componentanchored component of membrane basolateral plasma membrane integral component of plasma membrane extracellular exosome membrane integral component of external side of plasma membrane extracellular region plasma membrane cell surface apical plasma membraneBiological processhomotypic cell cell adhesion negative regulation of apoptotic process negative regulation of anoikis negative regulation of myotube differentiation C terminal protein lipidation leukocyte migration apoptotic process cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules heterophilic cell cell adhesion via plasma membrane cell adhesion moleculesSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1048n aEnsemblENSG00000105388n aUniProtP06731n aRefSeq mRNA NM 001291484NM 001308398NM 004363n aRefSeq protein NP 001278413NP 001295327NP 004354n aLocation UCSC Chr 19 41 71 41 73 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Functions 2 See also 3 References 4 Further reading 5 External linksFunctions editIn the literature CEACAM5 is often used as a synonym for cancer embryonic antigen CEA a well known biomarker of many types of malignancies such as colorectal cancer and non small cell lung cancer 4 5 Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells 6 Also it plays a significant role in the inhibition of differentiation 7 and apoptosis 8 in colon cells There are evidences that high CEACAM5 expression is firmly associated with the CD133 positive colorectal cancer stem cells 9 High CEACAM5 expression has also been identified in 25 of patients with advanced non squamous NSq non small cell lung cancer NSCLC detectable via IHC immunohistochemistry 10 11 See also editCluster of differentiationReferences edit a b c GRCh38 Ensembl release 89 ENSG00000105388 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene CEACAM5 carcinoembryonic antigen related cell adhesion molecule 5 Beauchemin N Arabzadeh A December 2013 Carcinoembryonic antigen related cell adhesion molecules CEACAMs in cancer progression and metastasis Cancer and Metastasis Reviews 32 3 4 643 671 doi 10 1007 s10555 013 9444 6 PMID 23903773 S2CID 10344352 Zhang X Han X Zuo P Zhang X Xu H September 2020 CEACAM5 stimulates the progression of non small cell lung cancer by promoting cell proliferation and migration The Journal of International Medical Research 48 9 300060520959478 doi 10 1177 0300060520959478 PMC 7536504 PMID 32993395 Benchimol S Fuks A Jothy S Beauchemin N Shirota K Stanners CP April 1989 Carcinoembryonic antigen a human tumor marker functions as an intercellular adhesion molecule Cell 57 2 327 334 doi 10 1016 0092 8674 89 90970 7 PMID 2702691 S2CID 30740594 Ilantzis C DeMarte L Screaton RA Stanners CP 2002 Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation Neoplasia 4 2 151 163 doi 10 1038 sj neo 7900201 PMC 1550325 PMID 11896570 Ordonez C Screaton RA Ilantzis C Stanners CP July 2000 Human carcinoembryonic antigen functions as a general inhibitor of anoikis Cancer Research 60 13 3419 3424 PMID 10910050 Gisina A Novikova S Kim Y Sidorov D Bykasov S Volchenko N et al 2021 01 01 CEACAM5 overexpression is a reliable characteristic of CD133 positive colorectal cancer stem cells Cancer Biomarkers 32 1 85 98 doi 10 3233 CBM 203187 PMID 34092615 S2CID 235359543 LaPointe N Hertle N Hsu SC Kellis J King N Littrell J et al 2021 05 20 Validation of an immunohistochemical assay CEACAM5 IHC 769 under development for use with the antibody drug conjugate tusamitamab ravtansine SAR408701 Journal of Clinical Oncology 39 15 suppl e21030 doi 10 1200 JCO 2021 39 15 suppl e21030 ISSN 0732 183X S2CID 236398737 Kim YJ Li W Zhelev DV Mellors JW Dimitrov DS Baek DS 2023 02 27 Chimeric antigen receptor T cells are effective against CEACAM5 expressing non small cell lung cancer cells resistant to antibody drug conjugates Frontiers in Oncology 13 1124039 doi 10 3389 fonc 2023 1124039 PMC 10010383 PMID 36923424 Further reading editWillcocks TC Craig IW November 1990 Characterization of the genomic organization of human carcinoembryonic antigen CEA comparison with other family members and sequence analysis of 5 controlling region Genomics 8 3 492 500 doi 10 1016 0888 7543 90 90036 T PMID 2286372 Barnett T Zimmermann W 1990 Workshop report proposed nomenclature for the carcinoembryonic antigen CEA gene family Tumour Biology 11 1 2 59 63 doi 10 1159 000217643 PMID 2309067 Schrewe H Thompson J Bona M Hefta LJ Maruya A Hassauer M et al June 1990 Cloning of the complete gene for carcinoembryonic antigen analysis of its promoter indicates a region conveying cell type specific expression Molecular and Cellular Biology 10 6 2738 2748 doi 10 1128 MCB 10 6 2738 PMC 360634 PMID 2342461 Kamarck ME Elting JJ Hart JT Goebel SJ Rae PM Nothdurft MA et al August 1987 Carcinoembryonic antigen family expression in a mouse L cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11 Proceedings of the National Academy of Sciences of the United States of America 84 15 5350 5354 Bibcode 1987PNAS 84 5350K doi 10 1073 pnas 84 15 5350 PMC 298853 PMID 2955415 Zimmermann W Ortlieb B Friedrich R von Kleist S May 1987 Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure Proceedings of the National Academy of Sciences of the United States of America 84 9 2960 2964 Bibcode 1987PNAS 84 2960Z doi 10 1073 pnas 84 9 2960 PMC 304780 PMID 3033671 Barnett T Goebel SJ Nothdurft MA Elting JJ July 1988 Carcinoembryonic antigen family characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop domains Genomics 3 1 59 66 doi 10 1016 0888 7543 88 90160 7 PMID 3220478 Zimmermann W Weber B Ortlieb B Rudert F Schempp W Fiebig HH et al May 1988 Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors Cancer Research 48 9 2550 2554 PMID 3356015 Beauchemin N Benchimol S Cournoyer D Fuks A Stanners CP September 1987 Isolation and characterization of full length functional cDNA clones for human carcinoembryonic antigen Molecular and Cellular Biology 7 9 3221 3230 doi 10 1128 MCB 7 9 3221 PMC 367958 PMID 3670312 Oikawa S Nakazato H Kosaki G January 1987 Primary structure of human carcinoembryonic antigen CEA deduced from cDNA sequence Biochemical and Biophysical Research Communications 142 2 511 518 doi 10 1016 0006 291X 87 90304 4 PMID 3814146 Maruyama K Sugano S January 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 174 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S October 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 156 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Hart SP Ross JA Ross K Haslett C Dransfield I May 2000 Molecular characterization of the surface of apoptotic neutrophils implications for functional downregulation and recognition by phagocytes Cell Death and Differentiation 7 5 493 503 doi 10 1038 sj cdd 4400680 PMID 10800083 Guignot J Peiffer I Bernet Camard MF Lublin DM Carnoy C Moseley SL Servin AL June 2000 Recruitment of CD55 and CD66e brush border associated glycosylphosphatidylinositol anchored proteins by members of the Afa Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco 2 TC7 cells Infection and Immunity 68 6 3554 3563 doi 10 1128 IAI 68 6 3554 3563 2000 PMC 97642 PMID 10816511 Boehm MK Perkins SJ June 2000 Structural models for carcinoembryonic antigen and its complex with the single chain Fv antibody molecule MFE23 FEBS Letters 475 1 11 16 doi 10 1016 S0014 5793 00 01612 4 PMID 10854848 S2CID 5765612 Screaton RA DeMarte L Draber P Stanners CP August 2000 The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl inositol anchor The Journal of Cell Biology 150 3 613 626 doi 10 1083 jcb 150 3 613 PMC 2175204 PMID 10931872 Bajenova OV Zimmer R Stolper E Salisbury Rowswell J Nanji A Thomas P August 2001 Heterogeneous RNA binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells The Journal of Biological Chemistry 276 33 31067 31073 doi 10 1074 jbc M104093200 PMID 11406629 Wirth T Soeth E Czubayko F Juhl H 2002 Inhibition of endogenous carcinoembryonic antigen CEA increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth Clinical amp Experimental Metastasis 19 2 155 160 doi 10 1023 A 1014566127493 PMID 11964079 S2CID 3138022 Louhimo J Carpelan Holmstrom M Alfthan H Stenman UH Jarvinen HJ Haglund C October 2002 Serum HCG beta CA 72 4 and CEA are independent prognostic factors in colorectal cancer International Journal of Cancer 101 6 545 548 doi 10 1002 ijc 90009 PMID 12237895 S2CID 7030523 Hampton R Walker M Marshall J Juhl H November 2002 Differential expression of carcinoembryonic antigen CEA splice variants in whole blood of colon cancer patients and healthy volunteers implication for the detection of circulating colon cancer cells Oncogene 21 51 7817 7823 doi 10 1038 sj onc 1205906 PMID 12420218 External links editCEACAM5 protein human at the U S National Library of Medicine Medical Subject Headings MeSH Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser PDBe KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen related cell adhesion molecule 5 CEACAM5 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte 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