The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.[1]
^Le Quesne JP, Stoneley M, Fraser GA, Willis AE (June 2001). "Derivation of a structural model for the c-myc IRES". Journal of Molecular Biology. 310 (1): 111–126. doi:10.1006/jmbi.2001.4745. PMID 11419940.
External linksedit
Page for c-myc internal ribosome entry site (IRES) at Rfam
internal, ribosome, entry, site, ires, internal, ribosome, entry, site, ires, element, present, mrna, allows, independent, translation, mammalian, gene, proto, oncogene, which, required, cell, proliferation, transformation, death, mrna, alternative, method, tr. The c myc internal ribosome entry site IRES is an RNA element present in the 5 UTR of the mRNA of C myc and allows cap independent translation The mammalian c myc gene is a proto oncogene which is required for cell proliferation transformation and death c myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5 UTR thus bypassing the typical eukaryotic cap dependent translation pathway 1 c myc internal ribosome entry site IRES Predicted secondary structure and sequence conservation of IRES c mycIdentifiersSymbolIRES c mycAlt Symbolsc myc IRESRfamRF00216Other dataRNA typeCis reg IRESDomain s EukaryotaGOGO 0043022SOSO 0000243PDB structuresPDBeReferences edit Le Quesne JP Stoneley M Fraser GA Willis AE June 2001 Derivation of a structural model for the c myc IRES Journal of Molecular Biology 310 1 111 126 doi 10 1006 jmbi 2001 4745 PMID 11419940 External links editPage for c myc internal ribosome entry site IRES at Rfam nbsp This molecular or cell biology article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title C myc internal ribosome entry site IRES amp oldid 919474635, wikipedia, wiki, book, books, library,
