BxPC-3 cells were derived from a 61-year-old female in 1986, and were confirmed to be tumorigenic in athymic nude mice, with moderate differentiation.[1] The cells produce mucin, and exhibit an epithelial morphology.[2] BxPC-3 cells lack a KRAS mutation,[3] though it is commonly found in pancreatic cancers.[4] BcPC-3 cells, along with JoPaca-1 cells, have high expression of cancer stem cell markers.[5]
BxPC-3 has been used in tumorigenicity studies, pancreatic cancer therapy research, and other biomedical applications. The cells have been additionally studied for their phenotypic and genotypic properties as they can be applied to pancreatic cancer drug development; in particular, BxPC-3 cells have high expression of the angiogenic factors IL-8, VEGF, and PGE2, which can serve as potential drug targets.[6]
^Tan, Mong H.; et al. (1986). "Characterization of a New Primary Human Pancreatic Tumor Line". Cancer Investigation. 4 (1): 15–23. doi:10.3109/07357908609039823. PMID 3754176.
^"ECACC General Cell Collection: BxPC-3". Public Health England. Retrieved 25 June 2018.
^"Cellosaurus BxPC-3 (CVCL_0186)". Cellosaurus. Retrieved 25 June 2018.
^Berrozpe, G; et al. (15 July 1994). "Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer". International Journal of Cancer. 58 (2): 185–191. doi:10.1002/ijc.2910580207. PMID 8026879. S2CID 40118099.
^Fredebohm, Johannes; et al. (12 November 2012). "Establishment and Characterization of a Highly Tumourigenic and Cancer Stem Cell Enriched Pancreatic Cancer Cell Line as a Well Defined Model System". PLOS ONE. 7 (11): e48503. Bibcode:2012PLoSO...748503F. doi:10.1371/journal.pone.0048503. PMC3495919. PMID 23152778.
^Deer, Emily; et al. (May 2010). "Phenotype and Genotype of Pancreatic Cancer Cell Lines". Pancreas. 39 (4): 425–435. doi:10.1097/MPA.0b013e3181c15963. PMC2860631. PMID 20418756.
External linksedit
Cellosaurus entry for BxPC-3
January 01, 1970
bxpc, bxpc3, human, pancreatic, cancer, cell, line, used, study, pancreatic, adenocarcinomas, treatments, thereof, cells, were, derived, from, year, female, 1986, were, confirmed, tumorigenic, athymic, nude, mice, with, moderate, differentiation, cells, produc. BxPC 3 BxPC3 is a human pancreatic cancer cell line used in the study of pancreatic adenocarcinomas and treatments thereof BxPC 3 cells were derived from a 61 year old female in 1986 and were confirmed to be tumorigenic in athymic nude mice with moderate differentiation 1 The cells produce mucin and exhibit an epithelial morphology 2 BxPC 3 cells lack a KRAS mutation 3 though it is commonly found in pancreatic cancers 4 BcPC 3 cells along with JoPaca 1 cells have high expression of cancer stem cell markers 5 BxPC 3 has been used in tumorigenicity studies pancreatic cancer therapy research and other biomedical applications The cells have been additionally studied for their phenotypic and genotypic properties as they can be applied to pancreatic cancer drug development in particular BxPC 3 cells have high expression of the angiogenic factors IL 8 VEGF and PGE2 which can serve as potential drug targets 6 See also editDU145 MIA PaCa 2 PANC 1References edit Tan Mong H et al 1986 Characterization of a New Primary Human Pancreatic Tumor Line Cancer Investigation 4 1 15 23 doi 10 3109 07357908609039823 PMID 3754176 ECACC General Cell Collection BxPC 3 Public Health England Retrieved 25 June 2018 Cellosaurus BxPC 3 CVCL 0186 Cellosaurus Retrieved 25 June 2018 Berrozpe G et al 15 July 1994 Comparative analysis of mutations in the p53 and K ras genes in pancreatic cancer International Journal of Cancer 58 2 185 191 doi 10 1002 ijc 2910580207 PMID 8026879 S2CID 40118099 Fredebohm Johannes et al 12 November 2012 Establishment and Characterization of a Highly Tumourigenic and Cancer Stem Cell Enriched Pancreatic Cancer Cell Line as a Well Defined Model System PLOS ONE 7 11 e48503 Bibcode 2012PLoSO 748503F doi 10 1371 journal pone 0048503 PMC 3495919 PMID 23152778 Deer Emily et al May 2010 Phenotype and Genotype of Pancreatic Cancer Cell Lines Pancreas 39 4 425 435 doi 10 1097 MPA 0b013e3181c15963 PMC 2860631 PMID 20418756 External links editCellosaurus entry for BxPC 3 Retrieved from https en wikipedia org w index php title BxPC 3 amp oldid 1161653393, wikipedia, wiki, book, books, library,
