In medicine, a bleb is a blister-like protrusion (often hemispherical) filled with serous fluid. Blebs can form in a number of tissues by different pathologies, including frostbite and can "appear and disappear within a short time interval".
In pathology pulmonary blebs are small subpleural thin-walled air-containing spaces, not larger than 1-2 cm in diameter. Their walls are less than 1 mm thick. If they rupture, they allow air to escape into pleural space, resulting in a spontaneous pneumothorax.[1][2]
In ophthalmology, blebs may be formed intentionally in the treatment of glaucoma. In such treatments, functional blebs facilitate the circulation of aqueous humor, the blockage of which will lead to increase in eye pressure. Use of collagen matrix wound modulation device such as ologen during glaucoma surgery is known to produce vascular and functional blebs, which are positively correlated with treatment success rate.[3][4][5][6]
In the lungs, a bleb is a collection of air within the layers of the visceral pleura.
In breasts a bleb is a milk blister (also known as blocked nipple pore, nipple blister, or “milk under the skin”).[7]
Pulmonary blebedit
A pulmonary bleb is a small air collection found in the upper lobe of the lung located between the lung and the visceral pleura. When a bleb ruptures, air escapes into the chest cavity, resulting in a pneumothorax and possibly a collapsed lung. Bulla occurs when blebs grow larger or join together to create a larger cyst. There are usually no symptoms unless a pneumothorax occurs or the bulla grows very large. Blebs are usually associated with emphysema.[8]
External linksedit
Medical definition of bleb on MedicineNet.com
Referencesedit
^Ponuwei, Godwin A.; Dash, Phil R. (2016-12-01). "Bleb Formation in Human Fibrosarcoma HT1080 Cancer Cell Line Is Positively Regulated by the Lipid Signalling Phospholipase D2 (PLD2)". Achievements in the Life Sciences. 10 (2): 125–135. doi:10.1016/j.als.2016.11.001. ISSN 2078-1520.
^Charras, Guillaume; Paluch, Ewa (July 16, 2008). "Blebs lead the way: how to migrate without lamellipodia". Nature Reviews Molecular Cell Biology. Springer Science and Business Media LLC. 9 (9): 730–736. doi:10.1038/nrm2453. ISSN 1471-0072.
^Yuan F, Li L, Chen X, Yan X, Wang L (2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for Treatment of Primary Open-Angle Glaucoma: Results at 5 Years". J Ophthalmol. 2015: 637537. doi:10.1155/2015/637537. PMC4452460. PMID 26078875.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Min JK, Kee CW, Sohn SW, Lee HJ, Woo JM, Yim JH (2013). "Surgical outcome of mitomycin C-soaked collagen matrix implant in trabeculectomy". J Glaucoma. 22 (6): 456–62. doi:10.1097/ijg.0b013e31826ab6b1. PMID 23263152. S2CID 20615016.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Boey PY, Narayanaswamy A, Zheng C, Perera SA, Htoon HM, Tun TA, Seah SK, Wong TT, Aung T (2011). "Imaging of blebs after phacotrabeculectomy with Ologen collagen matrix implants". Br J Ophthalmol. 95 (3): 340–4. doi:10.1136/bjo.2009.177758. PMID 20693559. S2CID 15912536.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Aptel F, Dumas S, Denis P (2009). "Ultrasound biomicroscopy and optical coherence tomography imaging of filtering blebs after deep sclerectomy with new collagen implant". Eur J Ophthalmol. 19 (2): 223–30. doi:10.1177/112067210901900208. PMID 19253238. S2CID 22594085.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Gaillard, Frank (February 16, 2021). "Radiology Reference Article". Radiopaedia. Retrieved November 18, 2023.
November 25, 2023
bleb, medicine, medicine, bleb, blister, like, protrusion, often, hemispherical, filled, with, serous, fluid, blebs, form, number, tissues, different, pathologies, including, frostbite, appear, disappear, within, short, time, interval, blue, rubber, bleb, nevu. In medicine a bleb is a blister like protrusion often hemispherical filled with serous fluid Blebs can form in a number of tissues by different pathologies including frostbite and can appear and disappear within a short time interval Bleb medicine Blue rubber bleb nevus syndromeIn pathology pulmonary blebs are small subpleural thin walled air containing spaces not larger than 1 2 cm in diameter Their walls are less than 1 mm thick If they rupture they allow air to escape into pleural space resulting in a spontaneous pneumothorax 1 2 In ophthalmology blebs may be formed intentionally in the treatment of glaucoma In such treatments functional blebs facilitate the circulation of aqueous humor the blockage of which will lead to increase in eye pressure Use of collagen matrix wound modulation device such as ologen during glaucoma surgery is known to produce vascular and functional blebs which are positively correlated with treatment success rate 3 4 5 6 In the lungs a bleb is a collection of air within the layers of the visceral pleura In breasts a bleb is a milk blister also known as blocked nipple pore nipple blister or milk under the skin 7 Pulmonary bleb editA pulmonary bleb is a small air collection found in the upper lobe of the lung located between the lung and the visceral pleura When a bleb ruptures air escapes into the chest cavity resulting in a pneumothorax and possibly a collapsed lung Bulla occurs when blebs grow larger or join together to create a larger cyst There are usually no symptoms unless a pneumothorax occurs or the bulla grows very large Blebs are usually associated with emphysema 8 External links editMedical definition of bleb on MedicineNet com Moorfields Bleb Grading SystemReferences edit Ponuwei Godwin A Dash Phil R 2016 12 01 Bleb Formation in Human Fibrosarcoma HT1080 Cancer Cell Line Is Positively Regulated by the Lipid Signalling Phospholipase D2 PLD2 Achievements in the Life Sciences 10 2 125 135 doi 10 1016 j als 2016 11 001 ISSN 2078 1520 Charras Guillaume Paluch Ewa July 16 2008 Blebs lead the way how to migrate without lamellipodia Nature Reviews Molecular Cell Biology Springer Science and Business Media LLC 9 9 730 736 doi 10 1038 nrm2453 ISSN 1471 0072 Yuan F Li L Chen X Yan X Wang L 2015 Biodegradable 3D Porous Collagen Matrix Ologen Compared with Mitomycin C for Treatment of Primary Open Angle Glaucoma Results at 5 Years J Ophthalmol 2015 637537 doi 10 1155 2015 637537 PMC 4452460 PMID 26078875 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Min JK Kee CW Sohn SW Lee HJ Woo JM Yim JH 2013 Surgical outcome of mitomycin C soaked collagen matrix implant in trabeculectomy J Glaucoma 22 6 456 62 doi 10 1097 ijg 0b013e31826ab6b1 PMID 23263152 S2CID 20615016 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Boey PY Narayanaswamy A Zheng C Perera SA Htoon HM Tun TA Seah SK Wong TT Aung T 2011 Imaging of blebs after phacotrabeculectomy with Ologen collagen matrix implants Br J Ophthalmol 95 3 340 4 doi 10 1136 bjo 2009 177758 PMID 20693559 S2CID 15912536 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link Aptel F Dumas S Denis P 2009 Ultrasound biomicroscopy and optical coherence tomography imaging of filtering blebs after deep sclerectomy with new collagen implant Eur J Ophthalmol 19 2 223 30 doi 10 1177 112067210901900208 PMID 19253238 S2CID 22594085 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint multiple names authors list link White spot on the nipple Gaillard Frank February 16 2021 Radiology Reference Article Radiopaedia Retrieved November 18 2023 Retrieved from https en wikipedia org w index php title Bleb medicine amp oldid 1185632875, wikipedia, wiki, book, books, library,
