Biobreeding rat also known as the BB or BBDP rat is an inbred laboratory rat strain that spontaneously develops autoimmuneType 1 Diabetes. Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes, and has contributed greatly to the research of T1D pathogenesis.[1]
Two T1D susceptibility genes have been identified in the BB rat. The susceptible MHC class II RT1u haplotype on chromosome 20 [2] and a null mutation in the GIMAP5 gene on chromosome 4.[3] The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells.[4] Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat.[5]
BB rats are the most extensively studied rat model of T1D. They were originally derived from a Canadian colony of outbred Wistar rats that spontaneously develop hyperglycemia and ketoacidosis, characteristic of clinical onset of T1D.[6] Subsequent BB rat colonies were established. One in Worcester, Massachusetts, has been inbred and known as BBDP/Wor and another one in Ottawa, Canada, an outbred strain known as BBdp.[7]
Modulation of diabetes
Diabetes in BB rats can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant (FCA).[8]
^Mordes JP, Poussier P, Blankenhorn EP, Greiner DL: Rat models of type 1 diabetes: Genetics, environment and autoimmunity. Boca Raton, CRC Press, 2007
^Colle, E., R.D. Guttmann, and T. Seemayer, Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. The Journal of experimental medicine, 1981. 154(4): p. 1237-42.
^Poussier, P., et al., Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. Endocrinology, 1982. 110(5): p. 1825-7.
^Poussier, P., et al., Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. Journal of Immunology, 2005. 174(7): p. 4081-9.
^Wallis RH, Wang K, Marandi L, Hsieh E, Ning T, Chao GY, Sarmiento J, Paterson AD, Poussier P.: Type 1 diabetes in the BB rat: a polygenic disease. Diabetes. 2009 Apr;58(4):1007-17. Epub 2009 Jan 23
^Mordes, J.P., et al., Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J, 2004. 45(3): p. 278-91.
^Mordes, J.P., et al., Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J, 2004. 45(3): p. 278-91.
^Sadelain MW, Qin HY, Sumoski W, Parfrey N, Singh B, Rabinovitch A. Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant. J Autoimmun; 1990 ; 3:671-80. PMID 2088390
January 21, 2023
biobreeding, also, known, bbdp, inbred, laboratory, strain, that, spontaneously, develops, autoimmune, type, diabetes, like, mice, rats, used, animal, model, type, diabetes, strain, capitulates, many, features, human, type, diabetes, contributed, greatly, rese. Biobreeding rat also known as the BB or BBDP rat is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes Like the NOD mice BB rats are used as an animal model for Type 1 diabetes The strain re capitulates many of the features of human type 1 diabetes and has contributed greatly to the research of T1D pathogenesis 1 Two T1D susceptibility genes have been identified in the BB rat The susceptible MHC class II RT1u haplotype on chromosome 20 2 and a null mutation in the GIMAP5 gene on chromosome 4 3 The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells 4 Recently 8 additional loci on rat chromosomes 1 2 3 6 2 loci 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat 5 Contents 1 History 2 Modulation of diabetes 3 See also 4 ReferencesHistory EditBB rats are the most extensively studied rat model of T1D They were originally derived from a Canadian colony of outbred Wistar rats that spontaneously develop hyperglycemia and ketoacidosis characteristic of clinical onset of T1D 6 Subsequent BB rat colonies were established One in Worcester Massachusetts has been inbred and known as BBDP Wor and another one in Ottawa Canada an outbred strain known as BBdp 7 Modulation of diabetes EditDiabetes in BB rats can be prevented by a single injection of mycobacterial adjuvants such as complete Freund s adjuvant FCA 8 See also EditNOD mice Type 1 Diabetes AutoimmunityReferences Edit Mordes JP Poussier P Blankenhorn EP Greiner DL Rat models of type 1 diabetes Genetics environment and autoimmunity Boca Raton CRC Press 2007 Colle E R D Guttmann and T Seemayer Spontaneous diabetes mellitus syndrome in the rat I Association with the major histocompatibility complex The Journal of experimental medicine 1981 154 4 p 1237 42 Poussier P et al Lymphopenia and abnormal lymphocyte subsets in the BB rat relationship to the diabetic syndrome Endocrinology 1982 110 5 p 1825 7 Poussier P et al Impaired post thymic development of regulatory CD4 25 T cells contributes to diabetes pathogenesis in BB rats Journal of Immunology 2005 174 7 p 4081 9 Wallis RH Wang K Marandi L Hsieh E Ning T Chao GY Sarmiento J Paterson AD Poussier P Type 1 diabetes in the BB rat a polygenic disease Diabetes 2009 Apr 58 4 1007 17 Epub 2009 Jan 23 Mordes J P et al Rat models of type 1 diabetes genetics environment and autoimmunity ILAR J 2004 45 3 p 278 91 Mordes J P et al Rat models of type 1 diabetes genetics environment and autoimmunity ILAR J 2004 45 3 p 278 91 Sadelain MW Qin HY Sumoski W Parfrey N Singh B Rabinovitch A Prevention of diabetes in the BB rat by early immunotherapy using Freund s adjuvant J Autoimmun 1990 3 671 80 PMID 2088390 Retrieved from https en wikipedia org w index php title Biobreeding rat amp oldid 809748130, wikipedia, wiki, book, books, library,
