Bernhard Brenner is a scientist who, through his experiments, elucidated the repeated cycles of stretch and release of muscle fibers under isometric conditions. Because of this, these cycles were named as "Brenner Cycles".
Biographyedit
Brenner was born in Stuttgart, capital of Baden-Württenberg state in Germany. He studied Medicine at the University of Tübingen between the years of 1969-1975. In 1980, Bernhard Brenner became associate researcher visitor at National Institute of Health (NIH) where he clarified that, when the muscle is in its relaxed state, the complex tropomyosin-troponin does not block cross-bridge bounds to actin. Due to this revelation, the pathway of muscle contraction was decoded, and then he correlated a rate of force for muscle redevelopment under calcium regulation called KTR to the number of cross-bridges turnover kinetics. Until 1985, Bernhard Brenner worked with other colleagues Richard Podolsky, Evan Eisenberg, Joseph Chalovich, Lois Greene, Mark Schoenberg, and Leepo Yu, and after this period,[1][2] Bernhard Brenner returned to Germany and became professor and director of the Institute for Molecular and Cell Physiology at Hannover Medical School (MHH). Later in his career, he started to study[3] mutations in cardiac myosin related to hypertrophic cardiomyopathy. He died in 2017,[4] from cancer.
Referencesedit
^Yu, L.C.; Brenner, B. (March 1989). "Structures of actomyosin crossbridges in relaxed and rigor muscle fibers". Biophysical Journal. 55 (3): 441–453. Bibcode:1989BpJ....55..441Y. doi:10.1016/S0006-3495(89)82838-3. PMC1330498. PMID 2930830.
^Kraft, T.; Chalovich, J.M.; Yu, L.C.; Brenner, B. (June 1995). "Parallel inhibition of active force and relaxed fiber stiffness by caldesmon fragments at physiological ionic strength and temperature conditions: additional evidence that weak cross-bridge binding to actin is an essential intermediate for force generation". Biophysical Journal. 68 (6): 2404–2418. Bibcode:1995BpJ....68.2404K. doi:10.1016/S0006-3495(95)80423-6. PMC1282151. PMID 7647245.
^Chalovich, Joseph M.; Kraft, Theresia; Yu, Leepo C. (2017-08-01). "Obituary Bernhard Brenner". Journal of Muscle Research and Cell Motility. 38 (3): 269–270. doi:10.1007/s10974-017-9488-2. ISSN 1573-2657. PMID 29147874. S2CID 2766175.
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bernhard, brenner, scientist, through, experiments, elucidated, repeated, cycles, stretch, release, muscle, fibers, under, isometric, conditions, because, this, these, cycles, were, named, brenner, cycles, biography, editbrenner, born, stuttgart, capital, bade. Bernhard Brenner is a scientist who through his experiments elucidated the repeated cycles of stretch and release of muscle fibers under isometric conditions Because of this these cycles were named as Brenner Cycles Biography editBrenner was born in Stuttgart capital of Baden Wurttenberg state in Germany He studied Medicine at the University of Tubingen between the years of 1969 1975 In 1980 Bernhard Brenner became associate researcher visitor at National Institute of Health NIH where he clarified that when the muscle is in its relaxed state the complex tropomyosin troponin does not block cross bridge bounds to actin Due to this revelation the pathway of muscle contraction was decoded and then he correlated a rate of force for muscle redevelopment under calcium regulation called KTR to the number of cross bridges turnover kinetics Until 1985 Bernhard Brenner worked with other colleagues Richard Podolsky Evan Eisenberg Joseph Chalovich Lois Greene Mark Schoenberg and Leepo Yu and after this period 1 2 Bernhard Brenner returned to Germany and became professor and director of the Institute for Molecular and Cell Physiology at Hannover Medical School MHH Later in his career he started to study 3 mutations in cardiac myosin related to hypertrophic cardiomyopathy He died in 2017 4 from cancer References edit Yu L C Brenner B March 1989 Structures of actomyosin crossbridges in relaxed and rigor muscle fibers Biophysical Journal 55 3 441 453 Bibcode 1989BpJ 55 441Y doi 10 1016 S0006 3495 89 82838 3 PMC 1330498 PMID 2930830 Kraft T Chalovich J M Yu L C Brenner B June 1995 Parallel inhibition of active force and relaxed fiber stiffness by caldesmon fragments at physiological ionic strength and temperature conditions additional evidence that weak cross bridge binding to actin is an essential intermediate for force generation Biophysical Journal 68 6 2404 2418 Bibcode 1995BpJ 68 2404K doi 10 1016 S0006 3495 95 80423 6 PMC 1282151 PMID 7647245 Kraft Theresia Montag Judith Radocaj Ante Brenner Bernhard 2016 10 14 Hypertrophic Cardiomyopathy Circulation Research 119 9 992 995 doi 10 1161 CIRCRESAHA 116 309804 PMID 27737944 Chalovich Joseph M Kraft Theresia Yu Leepo C 2017 08 01 Obituary Bernhard Brenner Journal of Muscle Research and Cell Motility 38 3 269 270 doi 10 1007 s10974 017 9488 2 ISSN 1573 2657 PMID 29147874 S2CID 2766175 nbsp nbsp This article about a German scientist is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Bernhard Brenner amp oldid 1010286331, wikipedia, wiki, book, books, library,
