Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4.[1]Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen’s Disease.[1] At bottom, columnar epithelium in normal sweat glands stain positive too.
Clinical useedit
BerEp4 has a high sensitivity and specificity in being positive only in BCC cells.[1] BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body.[3] It can also help in distinguishing pulmonary adenocarcinoma (positive BerEp4) from mesothelioma (generally negative BerEp4).[3][4]
^ abcdSunjaya, Anthony Paulo; Sunjaya, Angela Felicia; Tan, Sukmawati Tansil (2017). "The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma". Journal of Skin Cancer. 2017: 1–10. doi:10.1155/2017/2692604. ISSN 2090-2905. PMC5804366. PMID 29464122.
^"Ber-EP4". e-immunohistochemistry.info. Retrieved 24 May 2017.
^Ordóñez, Nelson G. (1998). "Value of the Ber-EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma:The M.D. Anderson Experience and a Critical Review of the Literature". American Journal of Clinical Pathology. 109 (1): 85–89. doi:10.1093/ajcp/109.1.85. ISSN 0002-9173. PMID 9426522.
April 11, 2024
berep4, also, histologic, stain, mainly, used, diagnosis, basal, cell, carcinoma, antibody, epcam, epithelial, cell, adhesion, molecule, comparison, stain, left, with, berep4, immunohistochemistry, staining, right, pathological, section, having, with, squamous. BerEp4 also Ber EP4 is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma BCC 2 It is an antibody to EpCAM epithelial cell adhesion molecule 1 Comparison H amp E stain left with BerEP4 immunohistochemistry staining right on a pathological section having BCC with squamous cell metaplasia Only BCC cells are stained with BerEP4 1 Comparison H amp E stain left with BerEP4 immunohistochemistry staining right on superficial BCC pathological sections mimicking Bowen s Disease 1 At bottom columnar epithelium in normal sweat glands stain positive too Clinical use editBerEp4 has a high sensitivity and specificity in being positive only in BCC cells 1 BerEp4 is normally negative in squamous epithelium and mesothelium but otherwise normally positive most epithelial cells of the body 3 It can also help in distinguishing pulmonary adenocarcinoma positive BerEp4 from mesothelioma generally negative BerEp4 3 4 See also editList of histologic stains that aid in diagnosis of cutaneous conditionsReferences edit a b c d Sunjaya Anthony Paulo Sunjaya Angela Felicia Tan Sukmawati Tansil 2017 The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma Journal of Skin Cancer 2017 1 10 doi 10 1155 2017 2692604 ISSN 2090 2905 PMC 5804366 PMID 29464122 Ber EP4 e immunohistochemistry info Retrieved 24 May 2017 a b Test ID BEREP Ber EP4 Epithelial Cell Adhesion Molecule EPCAM Immunostain Technical Component Only Mayo Clinic Laboratories Retrieved 2019 12 16 Ordonez Nelson G 1998 Value of the Ber EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma The M D Anderson Experience and a Critical Review of the Literature American Journal of Clinical Pathology 109 1 85 89 doi 10 1093 ajcp 109 1 85 ISSN 0002 9173 PMID 9426522 Retrieved from https en wikipedia org w index php title BerEp4 amp oldid 1060504929, wikipedia, wiki, book, books, library,
