Bandicoot papillomatosis carcinomatosis virus is a circular double-stranded DNA virus isolated from bandicoots (Perameles bougainville). The genome has features similar to viruses in the families Papillomaviridae and the Polyomaviridae. Two species have been described to date.[1]
The genome is ~7.5 kilobases in length with a G+C content of ~35%. Two structural genes are present: L1 and L2. The non structural genes are found on the opposite strand. The L1 gene encodes a protein with 506 residues and the L2 encodes a protein with 470 residues. The two non structural genes T (742 amino acid residues) and t (224 amino acid residues). The structural proteins resemble those of the papillomaviruses while the T and t antigens resemble those of the polyomaviruses.[citation needed]
Evolutionedit
These viruses evolved via a recombination event between a papillomavirus and a polyomavirus between 10 million years ago and 50 million years ago.[2]
Clinicaledit
These viruses were isolated from and are thought to cause a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome.[3] The lesions that occur in this disease are irregular thickenings and masses over the skin of the digits, body, pouch, and mucocutaneous junctions of the lips and conjunctiva. Cases have been described in both captive and wild individuals.[citation needed]
Referencesedit
^Bennett MD, Woolford L, Stevens H, Van Ranst M, Oldfield T, Slaven M, O'Hara AJ, Warren KS, Nicholls PK (2008) Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot (Isoodon obesulus) in Western Australia. Virology 376(1):173-182
^Bennett MD, Reiss A, Stevens H, Heylen E, Van Ranst M, Wayne A, Slaven M, Mills JN, Warren KS, O'Hara AJ, Nicholls PK (2010) The first complete papillomavirus genome characterized from a marsupial host: a novel isolate from Bettongia penicillata. J Virol 84(10):5448-5453
^Woolford L, Rector A, Van Ranst M, Ducki A, Bennett MD, Nicholls PK, Warren KS, Swan RA, Wilcox GE, O'Hara AJ (2007) A novel virus detected in papillomas and carcinomas of the endangered western barred bandicoot (Perameles bougainville) exhibits genomic features of both the Papillomaviridae and Polyomaviridae. J Virol 81(24):13280-13290
April 11, 2024
bandicoot, papillomatosis, carcinomatosis, virus, circular, double, stranded, virus, isolated, from, bandicoots, perameles, bougainville, genome, features, similar, viruses, families, papillomaviridae, polyomaviridae, species, have, been, described, date, viru. Bandicoot papillomatosis carcinomatosis virus is a circular double stranded DNA virus isolated from bandicoots Perameles bougainville The genome has features similar to viruses in the families Papillomaviridae and the Polyomaviridae Two species have been described to date 1 Bandicoot papillomatosis carcinomatosis virusVirus classificationGroup Group I dsDNA SpeciesBandicoot papillomatosis carcinomatosis virus 1 Bandicoot papillomatosis carcinomatosis virus 2 Contents 1 Genome 2 Evolution 3 Clinical 4 ReferencesGenome editThe genome is 7 5 kilobases in length with a G C content of 35 Two structural genes are present L1 and L2 The non structural genes are found on the opposite strand The L1 gene encodes a protein with 506 residues and the L2 encodes a protein with 470 residues The two non structural genes T 742 amino acid residues and t 224 amino acid residues The structural proteins resemble those of the papillomaviruses while the T and t antigens resemble those of the polyomaviruses citation needed Evolution editThese viruses evolved via a recombination event between a papillomavirus and a polyomavirus between 10 million years ago and 50 million years ago 2 Clinical editThese viruses were isolated from and are thought to cause a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome 3 The lesions that occur in this disease are irregular thickenings and masses over the skin of the digits body pouch and mucocutaneous junctions of the lips and conjunctiva Cases have been described in both captive and wild individuals citation needed References edit Bennett MD Woolford L Stevens H Van Ranst M Oldfield T Slaven M O Hara AJ Warren KS Nicholls PK 2008 Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot Isoodon obesulus in Western Australia Virology 376 1 173 182 Bennett MD Reiss A Stevens H Heylen E Van Ranst M Wayne A Slaven M Mills JN Warren KS O Hara AJ Nicholls PK 2010 The first complete papillomavirus genome characterized from a marsupial host a novel isolate from Bettongia penicillata J Virol 84 10 5448 5453 Woolford L Rector A Van Ranst M Ducki A Bennett MD Nicholls PK Warren KS Swan RA Wilcox GE O Hara AJ 2007 A novel virus detected in papillomas and carcinomas of the endangered western barred bandicoot Perameles bougainville exhibits genomic features of both the Papillomaviridae and Polyomaviridae J Virol 81 24 13280 13290 Retrieved from https en wikipedia org w index php title Bandicoot papillomatosis carcinomatosis virus amp oldid 1120533652, wikipedia, wiki, book, books, library,
