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Arturo Zychlinsky

January 07, 2023

Arturo Zychlinsky (born 1962) is a biologist and since 2001 director at the Max Planck Institute for Infection Biology.[1] His research focuses on Neutrophil Extracellular Traps (NETs) which he discovered together with Volker Brinkmann,[2] and the immune function of chromatin.

Arturo Zychlinsky discovered Neutrophil Extracellular Traps (NETs) together with Volker Brinkmann. This scanning electron image shows a NET (green), ejected by a neutrophil (yellow) to capture bacteria (purple). A red blood cell (orange) is also trapped in the NET.

Life

Arturo Zychlinsky completed his undergraduate studies at the Escuela Nacional de Ciencias Biológicas in Mexico City. In 1991, he obtained his PhD at the Rockefeller University where he trained with Ding-E Young in the laboratory of Zanvil Cohn. From 1991 to 1993 he was an EMBO postdoctoral fellow with Philippe J. Sansonetti at the Institut Pasteur. He then moved to the Skirball Institute, New York University School of Medicine, where he took a position as Assistant and Associate Professor. Since 2001, he is director of the Department for Cellular Microbiology at the Max Planck Institute for Infection Biology in Berlin.[3]

Research

Arturo Zychlinsky made several fundamental contributions including the first description that bacterial pathogens cause cell death and therefore induce inflammation.[4] He worked on the activation of Toll Like Receptors and their role in immunity[5][6] and he has made key contributions to understanding the role of neutrophils in innate immunity,[7] including the discovery of NETs, the description of Netosis, a novel form of cell death required for the release of NETs , the mechanism of NET formation,[8] the role of NETs in immunity[9] and autoimmunity[10]

Awards and honors

Arturo Zychlinsky received the Irma T. Hirschl Career Scientist Award, and the Eva and Klaus Grohe Award of the Berlin-Brandenburg Academy of Sciences.[11] He is a member of the European Molecular Biology Organization (EMBO), the German National Academy of Sciences Leopoldina,[12] the American Society and Academy of Microbiology, and the European Academy of Microbiology.

Personal life

Zychlinsky is married to the German zoologist and neuroethologist Constance Scharff; they have two daughters.[citation needed]

References

  1. ^ "Organization chart". www.mpiib-berlin.mpg.de. Retrieved 2021-05-07.
  2. ^ Brinkmann, Volker; Reichard, Ulrike; Goosmann, Christian; Fauler, Beatrix; Uhlemann, Yvonne; Weiss, David S.; Weinrauch, Yvette; Zychlinsky, Arturo (2004-03-05). "Neutrophil extracellular traps kill bacteria". Science. 303 (5663): 1532–1535. doi:10.1126/science.1092385. ISSN 1095-9203. PMID 15001782. S2CID 21628300.
  3. ^ "Cellular Microbiology". www.mpiib-berlin.mpg.de. Retrieved 2021-05-06.
  4. ^ Zychlinsky, Arturo; Prevost, Marie Christine; Sansonetti, Philippe J. (July 1992). "Shigella flexneri induces apoptosis in infected macrophages". Nature. 358 (6382): 167–169. doi:10.1038/358167a0. ISSN 1476-4687. S2CID 4260647.
  5. ^ Aliprantis, A. O.; Yang, R. B.; Mark, M. R.; Suggett, S.; Devaux, B.; Radolf, J. D.; Klimpel, G. R.; Godowski, P.; Zychlinsky, A. (1999-07-30). "Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2". Science. 285 (5428): 736–739. doi:10.1126/science.285.5428.736. ISSN 0036-8075. PMID 10426996.
  6. ^ Weiss, David S.; Raupach, Bärbel; Takeda, Kiyoshi; Akira, Shizuo; Zychlinsky, Arturo (2004-04-01). "Toll-Like Receptors Are Temporally Involved in Host Defense". The Journal of Immunology. 172 (7): 4463–4469. doi:10.4049/jimmunol.172.7.4463. ISSN 0022-1767. PMID 15034062.
  7. ^ Weinrauch, Yvette; Drujan, Doreen; Shapiro, Steven D.; Weiss, Jerrold; Zychlinsky, Arturo (2005-05-02). "Neutrophil elastase targets virulence factors of enterobacteria". Nature. 417 (6884): 91–94. doi:10.1038/417091a. ISSN 1476-4687. PMID 12018205. S2CID 4341470.
  8. ^ Papayannopoulos, Venizelos; Metzler, Kathleen D.; Hakkim, Abdul; Zychlinsky, Arturo (2010-11-01). "Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps". Journal of Cell Biology. 191 (3): 677–691. doi:10.1083/jcb.201006052. ISSN 1540-8140. PMC 3003309. PMID 20974816.
  9. ^ Urban, Constantin F.; Ermert, David; Schmid, Monika; Abu-Abed, Ulrike; Goosmann, Christian; Nacken, Wolfgang; Brinkmann, Volker; Jungblut, Peter R.; Zychlinsky, Arturo (2009-10-30). Levitz, Stuart M. (ed.). "Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans". PLOS Pathogens. 5 (10): e1000639. doi:10.1371/journal.ppat.1000639. ISSN 1553-7374. PMC 2763347. PMID 19876394.
  10. ^ Hakkim, A.; Furnrohr, B. G.; Amann, K.; Laube, B.; Abed, U. A.; Brinkmann, V.; Herrmann, M.; Voll, R. E.; Zychlinsky, A. (2010-05-25). "Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis". Proceedings of the National Academy of Sciences. 107 (21): 9813–9818. doi:10.1073/pnas.0909927107. ISSN 0027-8424. PMC 2906830. PMID 20439745.
  11. ^ "2005 – Berlin-Brandenburgische Akademie der Wissenschaften". www.bbaw.de. Retrieved 2021-05-06.
  12. ^ "Mitglieder". Nationale Akademie der Wissenschaften Leopoldina (in German). Retrieved 2021-05-06.

January 07, 2023
arturo, zychlinsky, born, 1962, biologist, since, 2001, director, planck, institute, infection, biology, research, focuses, neutrophil, extracellular, traps, nets, which, discovered, together, with, volker, brinkmann, immune, function, chromatin, discovered, n. Arturo Zychlinsky born 1962 is a biologist and since 2001 director at the Max Planck Institute for Infection Biology 1 His research focuses on Neutrophil Extracellular Traps NETs which he discovered together with Volker Brinkmann 2 and the immune function of chromatin Arturo Zychlinsky discovered Neutrophil Extracellular Traps NETs together with Volker Brinkmann This scanning electron image shows a NET green ejected by a neutrophil yellow to capture bacteria purple A red blood cell orange is also trapped in the NET Contents 1 Life 2 Research 3 Awards and honors 4 Personal life 5 ReferencesLife EditArturo Zychlinsky completed his undergraduate studies at the Escuela Nacional de Ciencias Biologicas in Mexico City In 1991 he obtained his PhD at the Rockefeller University where he trained with Ding E Young in the laboratory of Zanvil Cohn From 1991 to 1993 he was an EMBO postdoctoral fellow with Philippe J Sansonetti at the Institut Pasteur He then moved to the Skirball Institute New York University School of Medicine where he took a position as Assistant and Associate Professor Since 2001 he is director of the Department for Cellular Microbiology at the Max Planck Institute for Infection Biology in Berlin 3 Research EditArturo Zychlinsky made several fundamental contributions including the first description that bacterial pathogens cause cell death and therefore induce inflammation 4 He worked on the activation of Toll Like Receptors and their role in immunity 5 6 and he has made key contributions to understanding the role of neutrophils in innate immunity 7 including the discovery of NETs the description of Netosis a novel form of cell death required for the release of NETs the mechanism of NET formation 8 the role of NETs in immunity 9 and autoimmunity 10 Awards and honors EditArturo Zychlinsky received the Irma T Hirschl Career Scientist Award and the Eva and Klaus Grohe Award of the Berlin Brandenburg Academy of Sciences 11 He is a member of the European Molecular Biology Organization EMBO the German National Academy of Sciences Leopoldina 12 the American Society and Academy of Microbiology and the European Academy of Microbiology Personal life EditZychlinsky is married to the German zoologist and neuroethologist Constance Scharff they have two daughters citation needed References Edit Organization chart www mpiib berlin mpg de Retrieved 2021 05 07 Brinkmann Volker Reichard Ulrike Goosmann Christian Fauler Beatrix Uhlemann Yvonne Weiss David S Weinrauch Yvette Zychlinsky Arturo 2004 03 05 Neutrophil extracellular traps kill bacteria Science 303 5663 1532 1535 doi 10 1126 science 1092385 ISSN 1095 9203 PMID 15001782 S2CID 21628300 Cellular Microbiology www mpiib berlin mpg de Retrieved 2021 05 06 Zychlinsky Arturo Prevost Marie Christine Sansonetti Philippe J July 1992 Shigella flexneri induces apoptosis in infected macrophages Nature 358 6382 167 169 doi 10 1038 358167a0 ISSN 1476 4687 S2CID 4260647 Aliprantis A O Yang R B Mark M R Suggett S Devaux B Radolf J D Klimpel G R Godowski P Zychlinsky A 1999 07 30 Cell activation and apoptosis by bacterial lipoproteins through toll like receptor 2 Science 285 5428 736 739 doi 10 1126 science 285 5428 736 ISSN 0036 8075 PMID 10426996 Weiss David S Raupach Barbel Takeda Kiyoshi Akira Shizuo Zychlinsky Arturo 2004 04 01 Toll Like Receptors Are Temporally Involved in Host Defense The Journal of Immunology 172 7 4463 4469 doi 10 4049 jimmunol 172 7 4463 ISSN 0022 1767 PMID 15034062 Weinrauch Yvette Drujan Doreen Shapiro Steven D Weiss Jerrold Zychlinsky Arturo 2005 05 02 Neutrophil elastase targets virulence factors of enterobacteria Nature 417 6884 91 94 doi 10 1038 417091a ISSN 1476 4687 PMID 12018205 S2CID 4341470 Papayannopoulos Venizelos Metzler Kathleen D Hakkim Abdul Zychlinsky Arturo 2010 11 01 Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps Journal of Cell Biology 191 3 677 691 doi 10 1083 jcb 201006052 ISSN 1540 8140 PMC 3003309 PMID 20974816 Urban Constantin F Ermert David Schmid Monika Abu Abed Ulrike Goosmann Christian Nacken Wolfgang Brinkmann Volker Jungblut Peter R Zychlinsky Arturo 2009 10 30 Levitz Stuart M ed Neutrophil Extracellular Traps Contain Calprotectin a Cytosolic Protein Complex Involved in Host Defense against Candida albicans PLOS Pathogens 5 10 e1000639 doi 10 1371 journal ppat 1000639 ISSN 1553 7374 PMC 2763347 PMID 19876394 Hakkim A Furnrohr B G Amann K Laube B Abed U A Brinkmann V Herrmann M Voll R E Zychlinsky A 2010 05 25 Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis Proceedings of the National Academy of Sciences 107 21 9813 9818 doi 10 1073 pnas 0909927107 ISSN 0027 8424 PMC 2906830 PMID 20439745 2005 Berlin Brandenburgische Akademie der Wissenschaften www bbaw de Retrieved 2021 05 06 Mitglieder Nationale Akademie der Wissenschaften Leopoldina in German Retrieved 2021 05 06 Retrieved from https en wikipedia org w index php title Arturo Zychlinsky amp oldid 1127119532, wikipedia, wiki, book, books, library,

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